A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

A homologous protein-coding sequence in drosophila homeotic genes and its conservation in other metazoans

1984 • 920 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.

1984 • 776 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

The engrailed locus of drosophila: Structural analysis of an embryonic transcript

1985 • 735 citations

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

1984 • 686 citations

Molecular cloning of an enhancer binding protein:Isolation by screening of an expression library with a recognition site DNA

1988 • 677 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA

1981 • 651 citations

mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans

1988 • 573 citations

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.

1988 • 535 citations

Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

1988 • 525 citations

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

1986 • 496 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

Interaction of a Liver-Specific Nuclear Factor with the Fibrinogen and α ₁ -Antitrypsin Promoters

1987 • 485 citations

Identification and purification of a polypeptide that binds to the c-fos serum response element.

1987 • 398 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

A repressor (MATα2 product) and its operator control expression of a set of cell type specific genes in yeast

1985 • 368 citations

A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone

1987 • 347 citations

Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts

1985 • 346 citations

Expression and Function of the Segmentation Gene fushi tarazu During Drosophila Neurogenesis

1988 • 342 citations

Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins

1984 • 341 citations

Human prolactin. cDNA structural analysis and evolutionary comparisons.

1981 • 336 citations

Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes

1984 • 335 citations

Dwarf mice produced by genetic ablation of growth hormone-expressing cells.

1988 • 320 citations

Diversity of Alpha-Fetoprotein Gene Expression in Mice Is Generated by a Combination of Separate Enhancer Elements

1987 • 315 citations

A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells

1987 • 301 citations

Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila

1988 • 289 citations

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

1987 • 287 citations

The SV40 enhancer contains two distinct levels of organization

1988 • 286 citations

The sequence of the DNAs coding for the mating-type loci of saccharomyces cerevisiae

1981 • 286 citations

The segmentation and homeotic gene network in early Drosophila development

1987 • 286 citations

A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.

1988 • 239 citations

Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila

1984 • 220 citations

Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells

1985 • 209 citations

An immunohistochemical study on the cytogenesis of adenohypophysial cells in fetal rats

1979 • 206 citations

Spatial restriction in expression of a mouse homoeo box locus within the central nervous system

1986 • 203 citations

Transcriptional Regulation in the Yeast Life Cycle

1987 • 196 citations

Ontogenesis of cells producing polypeptide hormones (ACTH, MSH, LPH, GH, Prolactin) in the fetal hypophysis of the rat: Influence of the hypothalamus

1979 • 191 citations

Discrete cis-active genomic sequences dictate the pituitary cell type-specific expression of rat prolactin and growth hormone genes

1986 • 181 citations

Ontogeny of Prolactin Cells in Neonatal Rats: Initial Prolactin Secretors also Release Growth Hormone*

1985 • 179 citations

Two Different cis -Active Elements Transfer the Transcriptional Effects of Both EGF and Phorbol Esters

1986 • 161 citations

Developmental regulation of alpha-fetoprotein genes in transgenic mice.

1985 • 154 citations

The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

1987 • 109 citations

Many gene-regulatory proteins appear to have a similar α-helical fold that binds DNA and evolved from a common precursor

1983 • 107 citations

Identification of rat growth hormone genomic sequences targeting pituitary expression in transgenic mice.

1988 • 91 citations

Cell- and sequence-specific binding of nuclear proteins to 5′-flanking DNA of the rat growth hormone gene.

1987 • 90 citations

Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.

1987 • 89 citations

A novel, tissue-specific, Drosophila homeobox gene.

1988 • 80 citations

Selective transcription and DNase I protection of the rat prolactin gene by GH3 pituitary cell-free extracts.

1987 • 78 citations

Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo.

1988 • 72 citations

Identification by Cell Fusion of Gene Sequences That Interact with Positive Trans-Acting Factors

1987 • 68 citations

Reconstitution of cell-type-specific transcription of the rat prolactin gene in vitro.

1987 • 50 citations

Improved fixation and cobalt-glucose oxidase-diaminobenzidine intensification for immunohistochemical demonstration of corticotropin-releasing factor in rat brain.

1987 • 47 citations