Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Retinoblastoma: Clues to Human Oncogenesis

1984 • 495 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.

1987 • 432 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

1989 • 307 citations

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein

1990 • 295 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

Identification of Germline and Somatic Mutations Affecting the Retinoblastoma Gene

1988 • 270 citations

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.

1989 • 248 citations

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

1984 • 248 citations

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

1988 • 247 citations

An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110 and a second cellular protein, p120

1989 • 235 citations

Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma

1989 • 221 citations

When the products of oncogenes and anti-oncogenes meet

1989 • 213 citations

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

1990 • 204 citations

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.

1990 • 204 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.

1990 • 197 citations

C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.

1990 • 170 citations

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

1988 • 167 citations

Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells

1987 • 141 citations

Structure and partial genomic sequence of the human retinoblastoma susceptibility gene

1989 • 139 citations

Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology.

1988 • 137 citations

Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

1988 • 124 citations

The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells.

1989 • 104 citations

Studies of the retinoblastoma gene in human sarcomas.

1989 • 100 citations

Identification of a region of simian virus 40 large T antigen required for cell transformation

1990 • 90 citations

Membrane association of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses.

1983 • 89 citations

Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein.

1990 • 87 citations

Cytoplasmic microtubule-associated proteins: Phosphorylation at novel sites is correlated with their incorporation into assembled microtubules

1982 • 74 citations

Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen.

1990 • 52 citations

Chromomycin A3 as a fluorescent probe for flow cytometry of human gynecologic samples.

1977 • 51 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

1990 • 45 citations

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: Organization of the sequence and its encoded protein

1988 • 39 citations