An integrated view of pathophysiological models of schizophrenia

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Synaptic density in human frontal cortex — Developmental changes and effects of aging

1979 • 2,587 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 2,110 citations

Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

1991 • 2,025 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Molecular pathology of schizophrenia: more than one disease process?

1980 • 1,877 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 1,751 citations

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

1997 • 1,743 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Ketamine—Its Pharmacology and Therapeutic Uses

1982 • 1,490 citations

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

1982 • 1,352 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Pattern and time course of immediate early gene expression in rat brain following acute stress

1995 • 1,032 citations

Gene Expression for Glutamic Acid Decarboxylase Is Reduced Without Loss of Neurons in Prefrontal Cortex of Schizophrenics

1995 • 1,007 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Dopamine receptor pharmacology

1994 • 959 citations

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

1998 • 936 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

1995 • 891 citations

Hypofrontality in Neuroleptic-Naive Patients and in Patients With Chronic Schizophrenia

1992 • 882 citations

Prenatal developmental disturbances in the limbic allocortex in schizophrenics

1986 • 879 citations

Duration of psychosis and outcome in first-episode schizophrenia

1992 • 878 citations

Dopamine receptors and the dopamine hypothesis of schizophrenia

1987 • 867 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Drugs, Neurotransmitters, and Schizophrenia

1974 • 832 citations

Neuroleptics and the Natural Course of Schizophrenia

1991 • 777 citations

Symptoms of Schizophrenia

1995 • 734 citations

Pharmacologic effects of CI‐581, a new dissociative anesthetic, in man

1965 • 717 citations

Ketamine: an update on the first twenty-five years of clinical experience

1989 • 714 citations

Schizophrenia After Prenatal Exposure to the Dutch Hunger Winter of 1944-1945

1992 • 714 citations

Crises and Life Changes and the Onset of Schizophrenia

1968 • 685 citations

Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics

1997 • 670 citations

D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia

2005 • 670 citations

NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

1996 • 667 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

1993 • 660 citations

Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1988 • 602 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

A neurohistological correlate of schizophrenia.

1984 • 584 citations

The Genetics of Schizophrenia: A Current, Genetic-epidemiologic Perspective

1993 • 572 citations

Interchangeability of Stress and Amphetamine in Sensitization

1980 • 565 citations

Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia

1993 • 565 citations

The Glutamatergic Dysfunction Hypothesis for Schizophrenia

1996 • 558 citations

D-serine added to antipsychotics for the treatment of schizophrenia

1998 • 557 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia

1990 • 543 citations

Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment

1995 • 536 citations

Provocative tests with psychostimulant drugs in schizophrenia

1987 • 535 citations

Neuronal and Glial Somal Size in the Prefrontal Cortex

1998 • 530 citations

II. A Randomised Controlled Trial of Prophylactic Neuroleptic Treatment

1986 • 497 citations

A Neurodevelopmental Approach to the Classification of Schizophrenia

1992 • 496 citations

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11

1994 • 486 citations

The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.

1970 • 475 citations

Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia

1987 • 471 citations

Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains

1995 • 458 citations

An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

1985 • 457 citations

NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine

1996 • 450 citations

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development

1993 • 449 citations

Longitudinal Studies of Schizophrenic Patients

1980 • 441 citations

Ketamine activates psychosis and alters limbic blood flow in schizophrenia

1995 • 438 citations

The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

1989 • 426 citations

Epidemiology of Schizophrenia

1997 • 422 citations

Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine

1997 • 401 citations

Temporal Lobe Asymmetries as the Key to the Etiology of Schizophrenia

1990 • 398 citations

Time course of extracellular dopamine and behavioral sensitization to cocaine. II. Dopamine perikarya

1993 • 398 citations

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

1997 • 393 citations

Dissociative anesthesia: further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581.

1966 • 389 citations

Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

1994 • 378 citations

Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine

1995 • 357 citations

Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG)

1997 • 349 citations

Conditioning and Sensitisation in the Longitudinal Course of Affective Illness

1986 • 339 citations

Stress and the Mesocorticolimbic Dopamine Systemsa

1988 • 337 citations

Neurochemical Sensitization in the Pathophysiology of Schizophrenia: Deficits and Dysfunction in Neuronal Regulation and Plasticity

1997 • 336 citations

Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.

1994 • 334 citations

Causes and Consequences of the Gender Difference in Age at Onset of Schizophrenia

1998 • 331 citations

Comparison of Amphetamine Psychosis and Schizophrenia

1965 • 328 citations

Excitatory amino acids and neuropsychiatrie disorders

1989 • 327 citations

Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety

1996 • 325 citations

Amphetamine abuse. Pattern and effects of high doses taken intravenously

1967 • 324 citations

Stressful Life Events and Schizophrenia

1993 • 324 citations

Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients

1995 • 323 citations

Subchronic Phencyclidine Administration Reduces Mesoprefrontal Dopamine Utilization and Impairs Prefrontal Cortical-Dependent Cognition in the Rat

1997 • 320 citations

Long-Term Changes in Dopaminergic Innervation of Caudate Nucleus After Continuous Amphetamine Administration

1978 • 320 citations

Cocaine, kindling, and psychosis

1976 • 315 citations

Effects of Ketamine on Thought Disorder, Working Memory, and Semantic Memory in Healthy Volunteers

1998 • 305 citations

Dissociative Anesthesia

1966 • 293 citations

Recent Advances in the Neuropathology of Schizophrenia

1993 • 285 citations

Neurobiologic Antecedents of Schizophrenia in Children

1977 • 283 citations

Prediction of adult-onset schizophrenia from childhood home movies of the patients

1990 • 280 citations

Dopaminergic Mechanisms in Idiopathic and Drug-induced Psychoses

1990 • 279 citations

Dextroamphetamine

1972 • 274 citations

An overview of family interventions and relapse on schizophrenia: meta-analysis of research findings

1994 • 272 citations

A “Glutamatergic Hypothesis” of Schizophrenia

1989 • 270 citations

The tonic/phasic model of dopamine system regulation: its relevance for understanding how stimulant abuse can alter basal ganglia function

1995 • 263 citations

Limbic Motor Circuits and Neuropsychiatry

2019 • 254 citations

The Heterogeneity of the Long-Term Course of Schizophrenia

1988 • 249 citations

Antipsychotic agents antagonize non-competitiveN-methyl-d-aspartate antagonist-induced behaviors

1995 • 248 citations

Effect of 6‐Hydroxydopamine Lesions of the Medial Prefrontal Cortex on Neurotransmitter Systems in Subcortical Sites in the Rat

1980 • 242 citations

Stressful life events preceding the acute onset of schizophrenia: A cross-national study from the World Health Organization

1987 • 235 citations

Neurodevelopmental Schizophrenia: The Rediscovery of Dementia Praecox

1994 • 229 citations

Involvement of nigro-striatal neurons in the in vivo release of dopamine by amphetamine, amantadine and tyramine.

1973 • 229 citations

Relapse of Paranoid Psychotic State in Methamphetamine Model of Schizophrenia

1992 • 223 citations

NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus

1990 • 221 citations

Topographic patterns of brain activity in response to swim stress: assessment by 2-deoxyglucose uptake and expression of Fos-like immunoreactivity

1993 • 221 citations

The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia

1992 • 218 citations

Diagnosis and Classification of Schizophrenia

1993 • 216 citations

Factors influencing treatment response and outcome of first-episode schizophrenia: implications for understanding the pathophysiology of schizophrenia.

1996 • 215 citations

Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia?

1995 • 215 citations

Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients

1993 • 206 citations

Advancing a Neurodevelopmental Origin for Schizophrenia

1993 • 202 citations

Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study.

1988 • 201 citations

Glutamate Modulation of Dopamine Measured in Vivo with Positron Emission Tomography (PET) and 11C-Raclopride in Normal Human Subjects

1998 • 199 citations

Heterogeneity of Schizophrenia

1990 • 198 citations

Effects of NMDA antagonism on striatal dopamine release in healthy subjects: Application of a novel PET approach

1998 • 197 citations

Clozapine Blunts N-Methyl-d-Aspartate Antagonist-Induced Psychosis: A Study with Ketamine

1997 • 197 citations

Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine

1995 • 194 citations

Delayed effects of neonatal hippocampal damage on haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat

1993 • 189 citations

Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia

1993 • 186 citations

Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans

1998 • 185 citations

The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity

1984 • 181 citations

Infection and Autoimmunity as Etiologic Factors in Schizophrenia: A Review and Reappraisal

1993 • 179 citations

Patterns of Childhood Social Development in Adult Schizophrenics

1978 • 176 citations

Enhanced response to repeated d-amphetamine challenge: Evidence for behavioral sensitization in humans

1996 • 175 citations

Ketamine-induced Electroconvulsive Phenomena in the Human Limbic and Thalamic Regions

1973 • 173 citations

The behavioural effects of MK-801 in rats: involvement of dopaminergic, serotonergic and noradrenergic systems

1992 • 170 citations

Midazolam and diazepam in ketamine anaesthesia

1984 • 170 citations

The New Atypical Antipsychotics

1994 • 168 citations

Strong Inference, Theory Testing, and the Neuroanatomy of Schizophrenia

1993 • 164 citations

Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex

1993 • 164 citations

The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia

1972 • 163 citations

Subchronic Phencyclidine Administration Increases Mesolimbic Dopaminergic System Responsivity and Augments Stress- and Psychostimulant-Induced Hyperlocomotion

1998 • 162 citations

The interaction of ketamine with the opiate receptor

1980 • 160 citations

Observations on the psychotomimetic effects of sernyl

1961 • 159 citations

Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.

1997 • 158 citations

Amphetamine‐stimulated dopamine release competes in vivo for [¹²³I]IBZM binding to the D2 receptor in nonhuman primates

1992 • 157 citations

Non-competitive antagonists are potent activators of ventral tegmental A10 dopamine neurons

1990 • 157 citations

Seroquel restores sensorimotor gating in phencyclidine-treated rats.

1996 • 156 citations

Local Changes in Cerebral Glucose Utilization during Ketamine Anesthesia

1982 • 153 citations

Schizophrenia

1981 • 152 citations

Subtype Progression and Pathophysiologic Deterioration in Early Schizophrenia

1993 • 152 citations

Resting Cerebral Glucose Metabolism in First-Episode and Previously Treated Patients With Schizophrenia Relates to Clinical Features

1995 • 151 citations

Responses to apomorphine, amphetamine, and neuroleptics in schizophrenic subjects

1980 • 143 citations

Effect of the NMDA receptor antagonist, MK-801, on locomotor activity and on the metabolism of dopamine in various brain areas of mice

1991 • 141 citations

Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats

1992 • 140 citations

MK-801-induced stereotypy and its antagonism by neuroleptic drugs

1990 • 138 citations

Comparison of Phencyclidine Hydrochloride (Sernyl) with Other Drugs

1962 • 128 citations

Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation

1998 • 127 citations

Histological and ultrastructural evidence thatd-amphetamine causes degeneration in neostriatum and frontal cortex of rats

1990 • 125 citations

The Effect of 1-Arylcyclohexylamine (Sernyl) on Twelve Normal Volunteers

1960 • 125 citations

The genetics of schizophrenia

1991 • 124 citations

Typical and atypical neuroleptics antagonize MK-801-induced locomotion and stereotypy in rats

1992 • 122 citations

High-risk research in schizophrenia: A summary of what has been learned

1987 • 120 citations

Effect of phenycyclidine on dopamine release in the rat prefrontal cortex; an in vivo microdialysis study

1994 • 120 citations

Metabolic mapping of the rat brain after subanesthetic doses of ketamine: potential relevance to schizophrenia

1998 • 118 citations

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.

1996 • 117 citations

Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

1995 • 116 citations

Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity.

1996 • 115 citations

Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization

1993 • 111 citations

Regulation of excitatory amino acid release by N-methyl-d-aspartate receptors in rat striatum: in vivo microdialysis studies

1992 • 108 citations

Effects of Ketamine, MK-801, and Amphetamine on Regional Brain 2-Deoxyglucose Uptake in Freely Moving Mice

2000 • 107 citations

Electrophysiological effects of selective ?-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons

1989 • 106 citations

Effects of NMDA antagonists, MK-801 and CPP, upon local cerebral glucose use

1989 • 106 citations

Qualitative assessment of brain morphology in acute and chronic schizophrenia

1992 • 105 citations

Antipsychotic medication, D₂ dopamine receptor blockade and clinical response: a ¹²³I IBZM SPET (single photon emission tomography) study

1993 • 102 citations

Effects of dopamine D1 and D2 receptor blockade on MK-801-induced hyperlocomotion in rats

1993 • 101 citations

Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity

1996 • 100 citations

Enhanced stress-induced dopamine release in the prefrontal cortex of amphetamine-sensitized rats

1993 • 100 citations

Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity

1993 • 98 citations

The glycine/NMDA receptor antagonist, R‐(+)‐HA‐966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK‐801) in rodents

1993 • 94 citations

Glutamate in schizophrenia: clinical and research implications

1997 • 94 citations

The taming of ketamine*

1973 • 93 citations

Computed tomography (CT) findings in schizophrenia: Speculation on the meaning of it all

1984 • 93 citations

MK-801 elevates the etracellular concentration of dopamine in the rat prefrontal cortex and increases the density of striatal dopamine D1 receptors

1993 • 92 citations

Properties of the optical isomers and metabolites of ketamine on the high affinity transport and catabolism of monoamines

1981 • 92 citations

The role of dopamine and AMPA/kainate receptors in the nucleus accumbens in the hypermotility response to MK801

1993 • 90 citations

Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats.

1993 • 84 citations

Are the disparate pharmacological profiles of competitive and un-competitive NMDA antagonists due to different baseline activities of distinct glutamatergic pathways? (Hypothesis)

1993 • 80 citations

Positron Emission Tomography of in-vivo Binding Characteristics of Atypical Antipsychotic Drugs

1996 • 78 citations

High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients

1991 • 77 citations

In vivo regulation of extracellular dopamine in the neostriatum: influence of impulse activity and local excitatory amino acids

1993 • 76 citations

Ketamine-induced Changes in Regional Glucose Utilization in the Rat Brain

1980 • 72 citations

Methamphetamine-induced behavioral sensitization and its implications for relapse of schizophrenia

1994 • 70 citations

Effects of phencyclidine on ventral tegmental A10 dopamine neurons in the rat

1986 • 68 citations

Methylphenidate Response, Psychopathology and Tardive Dyskinesia as Predictors of Relapse in Schizophrenia

1994 • 67 citations

Behavioral sensitization to MK-801 (dizocilpine)

1993 • 67 citations

Behavioral changes in rats with early ventral hippocampal damage vary with age at damage

1997 • 66 citations

Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex

1990 • 66 citations

M100907 and Clozapine, but not Haloperidol or Raclopride, Prevent Phencyclidine-Induced Blockade of NMDA Responses in Pyramidal Neurons of the Rat Medial Prefrontal Cortical Slice

1998 • 66 citations

Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatum

1994 • 65 citations

Is There a Neuroanatomic Basis for Schizophrenia? An Old Question Revisited

1995 • 58 citations

Inhibition of mammalian brain acetylcholinesterase by ketamine

1974 • 56 citations

Amphetamine neurotoxicity on dopamine nerve terminals in the caudate nucleus of mice

1981 • 55 citations

NEURODEVELOPMENTAL AND NEUROPROGRESSIVE PROCESSES IN SCHIZOPHRENIA

1998 • 55 citations

Effects of competitive N-methyl-d-aspartate antagonists on midbrain dopamine neurons: An electrophysiological and behavioral comparison to phencyclidine

1991 • 54 citations

The non-NMDA glutamate receptor antagonist GYKI 52466 counteracts locomotor stimulation and anticataleptic activity induced by the NMDA antagonist dizocilpine

1993 • 53 citations

Does dizocilpine (MK-801) selectively block the enhanced responsiveness to repeated amphetamine administration?

1995 • 50 citations

Ketamine‐lorazepam

1978 • 49 citations

Does the noncompetitive NMDA receptor antagonist dizocilpine (MK801) really block behavioural sensitization associated with repeated drug administration?

1998 • 49 citations

Prefrontal cortical and hippocampal modulation of haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat

1995 • 48 citations

Methylphenidate increases thought disorder in recent onset schizophrenics, but not in normal controls

1993 • 48 citations

Auditory System of Noctuid Moths

1966 • 47 citations

Altered metabolic activity in the cerebral cortex of rats exposed to ketamine

1983 • 46 citations

MK-801 (Dizocilpine): Synergist and conditioned stimulus in bromocriptine-induced psychomotor sensitization

1996 • 46 citations

Neuropsychological differences between schizophrenic patients with heterogeneous Wisconsin Card Sorting Test performance

1996 • 45 citations

A Viral-Anatomical Explanation of Schizophrenia

1991 • 42 citations

Organic Brain Disorders: Classification, the “Symptomatic” Psychoses, Misdiagnosis

1978 • 40 citations

Does dizocilpine (MK-801) selectively block the enhanced responsiveness to repeated amphetamine administration?

1995 • 39 citations

Sensitization versus tolerance to the dopamine turnover-elevating effects of haloperidol: the effect of regular/intermittent dosing

1990 • 38 citations

Genetic Vulnerability to Schizophrenia

1986 • 37 citations

The Nithsdale Schizophrenia Surveys

1994 • 32 citations

Halothane and Diazepam Inhibit Ketamine-induced c-fos Expression in the Rat Cingulate Cortex

1996 • 31 citations

Stress reduction in the social environment of schizophrenic patients

1994 • 27 citations

Twin studies of psychopathology: Why do the concordance rates vary?

1991 • 27 citations

Evidence that adenosine receptors in the dog left atrium are not of the typical A1 or A2 adenosine receptor subtypes

1992 • 19 citations

Evidence for dissociable mechanisms of amphetamine-and stress-induced behavioral sensitization: effects of MK-801 and haloperidol pretreatment

1996 • 18 citations

Neuronal responses to ketamine administered microiontophoretically or intraperitoneally in the rat

1979 • 15 citations

Time to treatment response in successive episodes of early onset schizophrenia

1995 • 15 citations

Cortical Regulation of the Mesolimbic Dopamine System: Implications for Schizophrenia

2019 • 10 citations

7. Psychopathology and the question of neurodevelopmental or neurodegenerative disorder

1991 • 9 citations

[Midazolam and diazepam in ketamine anesthesia].

1987 • 9 citations