Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Neurogenetic Adaptive Mechanisms in Alcoholism

1987 • 2,300 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Aromatic Amino Acids and Modification of Parkinsonism

1967 • 1,464 citations

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Factors That Predict Individual Vulnerability to Amphetamine Self-Administration

1989 • 1,354 citations

Mesocorticolimbic dopaminergic network: functional and regulatory roles

1991 • 1,104 citations

A unified biosocial theory of personality and its role in the development of anxiety states.

1986 • 1,090 citations

Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.

1983 • 1,027 citations

Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET

1986 • 847 citations

Catecholamine theories of reward: A critical review

1978 • 766 citations

Imaging Dopamine Receptors in the Human Brain by Positron Tomography

1983 • 743 citations

Dopamine visualized in the basal ganglia of living man

1983 • 643 citations

The Mesolimbic Dopamine System: From Motivation to Action

1992 • 591 citations

Time course of nigrostriatal degeneration in parkinson's disease

1976 • 561 citations

Provocative tests with psychostimulant drugs in schizophrenia

1987 • 535 citations

Parkinson's disease: pathophysiology

1991 • 521 citations

Brain Microdialysis

1989 • 518 citations

Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro

1990 • 501 citations

Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain

1971 • 405 citations

Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration

1991 • 335 citations

Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress

1990 • 308 citations

Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography.

1985 • 304 citations

Mapping cocaine binding sites in human and baboon brain in vivo

1989 • 300 citations

Endogenous dopamine lowers the dopamine D₂ receptor density as measured by [³H]raclopride: Implications for positron emission tomography of the human brain

1989 • 298 citations

Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine

1991 • 292 citations

Striatal binding of the PET ligand ¹¹C‐raclopride is altered by drugs that modify synaptic dopamine levels

1993 • 285 citations

Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis study

1993 • 262 citations

Dopamine‐related personality traits in Parkinson's disease

1993 • 250 citations

Increased sensitivity to amphetamine and reward-related stimuli following social isolation in rats: possible disruption of dopamine-dependent mechanisms of the nucleus accumbens

1990 • 230 citations

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography

1992 • 211 citations

Link between D1 and D2 dopamine receptors is reduced in schizophrenia and Huntington diseased brain.

1989 • 197 citations

Quantitation of Carbon‐11‐labeled raclopride in rat striatum using positron emission tomography

1992 • 196 citations

Pharmacology of the enantiomers of threo-methylphenidate.

1987 • 192 citations

Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.

1993 • 183 citations

Experimental approach to individual vulnerability to psychostimulant addiction

1989 • 180 citations

Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age.

1992 • 179 citations

Amphetamine‐stimulated dopamine release competes in vivo for [¹²³I]IBZM binding to the D2 receptor in nonhuman primates

1992 • 157 citations

[³H]Threo‐(±)‐Methylphenidate Binding to 3,4‐Dihydroxyphenylethylamine Uptake Sites in Corpus Striatum: Correlation with the Stimulant Properties of Ritalinic Acid Esters

1985 • 153 citations

In vivoevaluation of striatal dopamine reuptake sites using 11C-nomifensine and positron emission tomography

1987 • 146 citations

Age‐related changes in the human nigrostriatal dopaminergic system

1990 • 145 citations

Microdialysis in the neurosciences

1992 • 128 citations

Effects of endogenous dopamine on kinetics of [³H]N‐methylspiperone and [³H]raclopride binding in the rat brain

1991 • 122 citations

Annual Reports in Medicinal Chemistry, 1965.

1967 • 118 citations

Decreased density of human striatal dopamine uptake sites with age

1986 • 116 citations

Effects of endogenous dopamine on measures of [¹⁸F]N‐methylspiroperidol binding in the basal ganglia: Comparison of simulations and experimental results from PET studies in baboons

1991 • 105 citations

Amphetamine induced decreases in (¹⁸F)‐N‐methylspiroperidol binding in the baboon brain using positron emission tomography (PET)

1991 • 91 citations

In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine‐123 labeled RTI‐55

1992 • 84 citations

Anesthetic influences on the basal acticity and pharmacological responsiveness of nigrostriatal dopamine neurons

1990 • 80 citations

Kinetic properties of the accumulation of 3H-raclopride in the mouse brain in vivo

1989 • 79 citations

In vivo quantitative imaging of dopamine receptors in human brain using positron emission tomography and [76Br]bromospiperone

1985 • 77 citations

Nomifensine‐induced increased in extracellular striatal dopamine is enhanced by isoflurane anaesthesia

1991 • 71 citations

PET analysis of central [¹¹ C]raclopride binding in healthy young adults and schizophrenic patients—reliability and age effects

1992 • 68 citations

In Vivo Imaging of Vesicular Monoamine Transporters in Human Brain Using [¹¹C]Tetrabenazine and Positron Emission Tomography

1993 • 67 citations

4‐[¹⁸F]Fluoro‐L‐m‐Tyrosine: An L‐3,4‐Dihydroxyphenylalanine Analog for Probing Presynaptic Dopaminergic Function with Positron Emission Tomography

1989 • 60 citations

Effects of halothane anaesthesia on extracellular levels of dopamine, dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindolacetic acid in rat striatum: a microdialysis study

1990 • 56 citations

Online coupling of in vivo microdialysis with tandem mass spectrometry

1992 • 47 citations

In vivo binding of [18F]GBR 13119 to the brain dopamine uptake system

1988 • 45 citations

Parkinson's Disease: Past, Present, and Future

1993 • 42 citations

Does impaired primacy recall equal impaired long‐term storage?: Serial position effects in Huntington's disease and Alzheimer's disease

1993 • 39 citations

Difference in in vivo receptor binding between [3 H]N-methylspiperone and [3 H]raclopride in reserpine-treated mouse brain

1991 • 31 citations

Selectivity of agonists and antagonists at D₂dopamine receptors compared to D₁ and S₂receptors

1986 • 30 citations

Mapping brain neuroleptic receptors in the live baboon.

1984 • 28 citations

[3H]CFT ([3H]win 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey

1993 • 23 citations