The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The current status of the dopamine hypothesis of schizophrenia

1988 • 962 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

1989 • 495 citations

Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models

1988 • 320 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 229 citations

Biological Psychiatry

1986 • 218 citations

A simple model for studying benzodiazepines: Potentiation of hyperactivity induced by cocaine in mice

1982 • 193 citations

Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats

1989 • 168 citations

Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 137 citations

Behavioural effects of N-methyl-D-aspartate in the anterodorsal striatum of the rat

1988 • 63 citations

[A biochemical theory of schizophrenia].

1984 • 33 citations