NEURODEVELOPMENTAL AND NEUROPROGRESSIVE PROCESSES IN SCHIZOPHRENIA

J Neuropsychiatry Clin Neurosci

1992 • 3,756 citations

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop

1995 • 2,101 citations

Anatomical Evidence for Cerebellar and Basal Ganglia Involvement in Higher Cognitive Function

1994 • 1,330 citations

Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort

1994 • 1,326 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Gene Expression for Glutamic Acid Decarboxylase Is Reduced Without Loss of Neurons in Prefrontal Cortex of Schizophrenics

1995 • 1,007 citations

Patterns of Cerebral Blood Flow in Schizophrenia

1992 • 905 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Duration of psychosis and outcome in first-episode schizophrenia

1992 • 878 citations

Abnormally High Neuronal Density in the Schizophrenic Cortex

1995 • 866 citations

Is schizophrenia a neurodevelopmental disorder?

1987 • 838 citations

Neuroleptics and the Natural Course of Schizophrenia

1991 • 777 citations

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

1995 • 741 citations

Myelination of a Key Relay Zone in the Hippocampal Formation Occurs in the Human Brain During Childhood, Adolescence, and Adulthood

1994 • 740 citations

The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life.

1993 • 719 citations

Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging

1994 • 699 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

1993 • 660 citations

Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry.

1996 • 618 citations

Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients

1997 • 593 citations

From neuropathology to neurodevelopment

1995 • 569 citations

Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics

1990 • 558 citations

Lesions of the perirhinal and parahippocampal cortices in the monkey produce long-lasting memory impairment in the visual and tactual modalities

1993 • 548 citations

Is Schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited

1994 • 507 citations

II. A Randomised Controlled Trial of Prophylactic Neuroleptic Treatment

1986 • 497 citations

Schizophrenia

1994 • 489 citations

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11

1994 • 486 citations

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development

1993 • 449 citations

Psychotic Illness in Patients Diagnosed with Velo-Cardio-Facial Syndrome and Their Relatives

1994 • 434 citations

Neuromotor Precursors of Schizophrenia

1994 • 434 citations

The organization of the basal ganglia-thalamocortical circuits: Open interconnected rather than closed segregated

1994 • 422 citations

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia

1992 • 421 citations

Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics

1997 • 419 citations

Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients

1996 • 391 citations

Neuropsychological Deficits in Schizophrenics

1994 • 387 citations

Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12‐q13.1: Part 1

1994 • 387 citations

Bipolar spectrum disorders in patients diagnosed with velo-cardio- facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder?

1996 • 368 citations

Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia

1997 • 367 citations

Decreased regional cortical gray matter volume in schizophrenia

1994 • 356 citations

Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains.

1995 • 331 citations

Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients

1995 • 323 citations

PET and MRI of the thalamus in never-medicated patients with schizophrenia

1996 • 319 citations

Severity of symptoms in chronically institutionalized geriatric schizophrenic patients

1995 • 307 citations

Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study

1997 • 292 citations

Intellectual Deficits in First-Episode Schizophrenia: Evidence for Progressive Deterioration

1992 • 291 citations

Derbyshire Neck. Thyroid abnormalities in the Derbyshire Peak district.

1966 • 279 citations

Anomalies of the corpus callosum: correlation with further anomalies of the brain

1988 • 270 citations

A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: Preliminary findings

1995 • 263 citations

Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes

1995 • 258 citations

The genetic basis for schizophrenia

1973 • 247 citations

Structural brain abnormalities in the major psychoses: A quantitative review of the evidence from computerized imaging.

1990 • 245 citations

Schizophrenia: A disease of heteromodal association cortex?

1996 • 234 citations

A combined analysis of D22S278 marker alleles in affected sib-pairs: Support for a susceptibility locus for schizophrenia at chromosome 22q12

1996 • 232 citations

Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas.

1997 • 228 citations

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

1993 • 222 citations

Minor Physical Anomalies in Schizophrenia

1989 • 220 citations

Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia

1996 • 210 citations

Human fetal hippocampal development: I. Cytoarchitecture, myeloarchitecture, and neuronal morphologic features

1996 • 206 citations

Recent advances in defining the neuropathology of schizophrenia

1996 • 206 citations

Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish Study of High-Density Schizophrenia Families

1996 • 204 citations

Developmentally Moderated Expressions of the Neuropathology Underlying Schizophrenia

1994 • 203 citations

The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics

1992 • 202 citations

Chidhood precursors of psychiosis as clues to its evolutionary orgins

1995 • 200 citations

The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins

1997 • 197 citations

Schizophrenia: developmental neuroscience and pathobiology

1993 • 196 citations

Course of Schizophrenia: Neuropsychological Evidence for a Static Encephalopathy

1993 • 187 citations

Meta-analysis of brain and cranial size in schizophrenia

1996 • 183 citations

Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia

1995 • 183 citations

Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia

1997 • 176 citations

Human cortex development: estimates of neuronal numbers indicate major loss late during gestation.

1996 • 168 citations

1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates

1994 • 155 citations

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development

1997 • 155 citations

Course of treatment response in first-episode and chronic schizophrenia

1996 • 155 citations

The case for heterogeneity in the etiology of schizophrenia

1995 • 154 citations

Schizophrenia and the myth of intellectual decline

1997 • 153 citations

Subtype Progression and Pathophysiologic Deterioration in Early Schizophrenia

1993 • 152 citations

Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?

1997 • 152 citations

Programmed cell death: Implications for neuropsychiatric disorders

1994 • 147 citations

Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia

1997 • 146 citations

Schizophrenia, the heteromodal association neocortex and development: potential for a neurogenetic approach

1996 • 141 citations

Embryology of the human fetal hippocampus: MR imaging, anatomy, and histology.

1997 • 141 citations

Is There Cognitive Decline in Schizophrenia?

1994 • 138 citations

Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging

1997 • 135 citations

Neural Crest Apoptosis and the Establishment of Craniofacial Pattern: An Honorable Death

1996 • 134 citations

Cognitive impairment and negative symptoms in geriatric chronic schizophrenic patients: a follow-up study

1996 • 134 citations

Human Cortex Development

1996 • 132 citations

Outcome study of first-episode psychosis. I: Relapse rates after 1 year

1986 • 130 citations

Stability of cognitive functioning early in the course of schizophrenia

1994 • 130 citations

Increased Concentrations of Presynaptic Proteins in the Cingulate Cortex of Subjects With Schizophrenia

1997 • 127 citations

Increased Rate of P300 Latency Prolongation With Age in Schizophrenia

1995 • 127 citations

Second-trimester markers of fetal size in schizophrenia: a study of monozygotic twins

1992 • 125 citations

Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects

1996 • 124 citations

Decreased anterior cingulate gyrus metabolic rate in schizophrenia

1997 • 124 citations

The life course of schizophrenia: age and symptom dimensions

1997 • 123 citations

Cortical gray matter volume deficit in patients with first-episode schizophrenia

1996 • 118 citations

Glial fibrillary acidic protein-immunoreactive astrocytosis in elderly patients with schizophrenia and dementia

1996 • 116 citations

Minor physical anomalies in psychoses: associations with clinical and putative aetiological variables

1995 • 112 citations

Prospective clinicopathologic studies of schizophrenia: accrual and assessment of patients

1995 • 112 citations

The normal and abnormal genu of the corpus callosum: an evolutionary, embryologic, anatomic, and MR analysis.

1996 • 110 citations

Skull base and calvarial deformities : Association with intracranial changes in craniofacial syndromes

1996 • 109 citations

Lack of a bimodal distribution of ventricular size in schizophrenia: A Gaussian mixture analysis of 1056 cases and controls

1991 • 109 citations

Psychopathology, executive (frontal) and general cognitive impairment in relation to duration of initially untreated versus subsequently treated psychosis in chronic schizophrenia

1997 • 108 citations

Sequential cross-sectional and 10-year prospective study of severe negative symptoms in relation to duration of initially untreated psychosis in chronic schizophrenia

1995 • 107 citations

Long-term morbidity associated with delayed treatment of first admission schizophrenic patients: a re-analysis of the Camarillo State Hospital data

1997 • 107 citations

Head Circumference in ‘Preschizophrenic’ and Control Neonates

1993 • 107 citations

Barx2 , a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development

1997 • 101 citations

Development of human craniofacial morphology during the late embryonic and early fetal periods

1985 • 100 citations

Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with11C-N-methylspiperone

1993 • 99 citations

The deficit state in first-episode schizophrenia

1994 • 98 citations

Congenital risk factors for schizophrenia

1989 • 97 citations

Premorbid adjustment as a predictor of phenomenological and neurobiological indices in schizophrenia

1995 • 94 citations

Disturbances in cell recognition molecules (N-CAM and L1 antigen) in the CSF of patients with schizophrenia

1995 • 94 citations

The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging

1995 • 92 citations

Childhood behavioral precursors of adult symptom dimensions in schizophrenia

1995 • 89 citations

Childhood behavioral characteristics and adult brain morphology in schizophrenia

1996 • 89 citations

Reciprocal entorhinal-hippocampal connections established by human fetal midgestation

1996 • 87 citations

Fibrin degradation products in post mortem brain tissue of schizophrenics: a possible marker for underlying inflammatory processes

1996 • 87 citations

Psychotic features and the course of Alzheimer's disease: relationship to cognitive, electroencephalographic and computerized tomography findings

1993 • 87 citations

Deterioration in premorbid functioning in schizophrenia: a developmental model of negative symptoms in drug-free patients

1992 • 86 citations

The Longitudinal Stability of Cognitive Impairment in Schizophrenia

1995 • 86 citations

Recent Advances in Primary Palate and Midface Morphogenesis Research

1992 • 85 citations

Preliminary evidence for an association between minor physical anomalies and second trimester neurodevelopment in schizophrenia

1994 • 85 citations

Anomalies of the Corpus Callosum: Correlation with Further Anomalies of the Brain

1988 • 82 citations

The functional architecture of the prefrontal cortex and schizophrenia

1995 • 78 citations

MRI brain abnormalities in chronic schizophrenia: One process or more?

1996 • 77 citations

Dermatoglyphic a-b ridge count as a possible marker for developmental disturbance in schizophrenia: replication in two samples

1996 • 76 citations

Reduction in hippocampal formation volume is caused mainly by its shortening in chronic schizophrenia: Assessment by MRI

1996 • 73 citations

Neurodynamics of Abnormalities in Cerebral Metabolism and Structure in Schizophrenia

1993 • 70 citations

The neurodevelopmental basis of schizophrenia

1996 • 69 citations

The DiGeorge syndrome minimal critical region contains a goosecoid-like (GSCL) homeobox gene that is expressed early in human development.

1997 • 68 citations

Midline cerebral malformations and schizophrenia

1993 • 64 citations

Dopamine induces apoptosis in cultured rat striatal neurons; possible mechanism of D2-dopamine receptor neuron loss during aging

1997 • 63 citations

Informative morphogenetic variants in patients with schizophrenia and alcohol-dependent patients: beyond the Waldrop Scale

1997 • 61 citations

What's in a face?

1996 • 60 citations

Monozygotic twins discordant for schizophrenia are discordant for N-CAM and L1 in CSF

1997 • 58 citations

Soft-Palate Myogenesis: A Developmental Field Paradigm

1993 • 58 citations

Small head circumference at birth in schizophrenia

1996 • 56 citations

Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia [published erratum appears in Am J Psychiatry 1997 Aug;154(8):1180]

1997 • 55 citations

Computer reconstructions of human embryonic craniofacial morphology showing changes in relations between the face and brain during primary palate formation.

1993 • 55 citations

Cortical gray matter volume deficits in schizophrenia: a replication

1996 • 54 citations

Early areal differentiation of the human cerebral cortex: Entorhinal area

1993 • 54 citations

Neuronal Misconnections and Psychiatric Disorder

1989 • 54 citations

Minor Physical Anomalies in Schizophrenia

1994 • 52 citations

Prenatal Development of NADPH-diaphorase-Reactive Neurons in Human Frontal Cortex

1996 • 49 citations

The expression of an N-CAM serum fragment is positively correlated with severity of negative features in type II schizophrenia

1988 • 49 citations

Prenatal growth markers in schizophrenia: a monozygotic co-twin control study

1996 • 49 citations

Schizophrenia and chromosome 6p

1997 • 47 citations

Limbic lobe embryology and anatomy: dissection and MR of the medial surface of the fetal cerebral hemisphere.

1995 • 46 citations

Chromosome 22q11.2 microdeletions in velocardiofacial syndrome patients with widely variable manifestations

1996 • 46 citations

A case against subtyping in schizophrenia

1995 • 45 citations

Symptom stability in geriatric chronic schizophrenic inpatients: A one-year follow-up study

1996 • 42 citations

Developmental insanity or dementia praecox: was the wrong concept adopted?

1997 • 42 citations

Cognitive Impairment in Elderly Schizophrenia: A Dementia (Still) Lacking Distinctive Histopathology

1996 • 40 citations

Early development of the human thalamus: Golgi and Nissl study

1991 • 40 citations

Growth and morphogenesis of the human embryonic midface during primary palate formation analyzed in frontal sections.

1993 • 40 citations

Developmental trajectory and disease progression in schizophrenia: the conundrum, and insights from a 12-year prospective study in the Monaghan 101

1997 • 39 citations

Course of psychopathology, cognition and neurobiological abnormality in schizophrenia: developmental origins and amelioration by antipsychotics?

1998 • 38 citations

The ventricle-brain ratio (VBR) in functional psychoses: An admixture analysis

1990 • 38 citations

A morphometric analysis of human embryonic craniofacial growth in the median plane during primary palate formation.

1993 • 37 citations

GAP-43 mRNA expression in early development of human nervous system

1996 • 35 citations

Soft-Palate Myogenesis: A Developmental Field Paradigm

1993 • 34 citations

Further evidence for anomalies in the hand-prints of patients with schizophrenia: a study of secondary creases

1994 • 34 citations

Analysis of glial fibrillary acidic protein, neurofilament protein, actin and heat shock proteins in human fetal brain during the second trimester

1996 • 34 citations

Time course of cerebral ventricular enlargement in schizophrenia supports the hypothesis of its neurodevelopmental nature

1997 • 33 citations

First Year of Life: Prenatal Craniofacial Development

1992 • 32 citations

Negative symptoms and the early course of schizophrenia

1992 • 31 citations

Midline developmental “weakness” as a consequence of determinative field properties

1987 • 30 citations

Abnormalities in midline attentional circuitry in schizophrenia: evidence from magnetic resonance and positron emission tomography

1995 • 30 citations

Prenatal development of nicotinamide adenine dinucleotide phosphate-diaphorase activity in the human hippocampal formation

1997 • 27 citations

Terminal deletion in chromosome region 8p23.1-8pter in a child with features of velo-cardio-facial syndrome.

1995 • 26 citations

Malformations of the Brain

1996 • 19 citations

Executive (frontal) dysfunction and negative symptoms in schizophrenia: Apparent gender differences in ‘static’ v. ‘progressive’ profiles

1997 • 19 citations

Photoanthropometric study of craniofacial traits of individuals with Prader‐Willi syndrome

1995 • 19 citations

Soft neurological signs and minor physical anomalies in schizophrenia.

1989 • 16 citations

Partial Deletion of Chromosome 6p: Autopsy Findings in a Premature Infant and Review of the Literature

1995 • 14 citations

Increased head circumference in schizophrenia

1996 • 13 citations

The molecular genetics of schizophrenia: Progress so far

1997 • 11 citations

Developmental abnormalities and cortical sulcal enlargement in psychosis

1995 • 10 citations

The Enigma of Cephalogenesis

1994 • 10 citations

Midsagittal dimensions of the prenatal human cranium.

1995 • 10 citations

The Enigma of Cephalogenesis

1994 • 10 citations

Negative labelling of individuals with first episode schizophrenia: the effect of premorbid functioning

1996 • 10 citations

A neuropsychological perspective on three schizophrenic patients with midline structural defects

1997 • 9 citations

Craniofacial dysmorphology in schizophrenia

1997 • 7 citations

Common Molecular Pathways for Patterning of the Body Axis, Limbs, Central Nervous System, and Face during Embryonic Development

1995 • 5 citations

Early beginnings for adult brain pathology

1997 • 5 citations

Morphometry in schizophrenia revisited: Height and its relationship to premorbid function

1997 • 4 citations

Age dependent change of ventricular measures in schizophrenia: Cross-sectional analysis

1994 • 4 citations

Functional imaging and the neurobiology of the psychoses

1995 • 3 citations

Common Molecular Pathways for Patterning of the Body Axis, Limbs, Central Nervous System and Face during Embryonic Development

1995 • 3 citations