4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.

1988 • 421 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

1985 • 362 citations

Free radicals in liver injury

1987 • 338 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Thrombin‐induced increase in albumin permeability across the endothelium

1986 • 307 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Aldehydes in biological systems : their natural occurrence and biological activities

1977 • 173 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

The reaction of cysteine with α,β-unsaturated aldehydes

1976 • 160 citations

Cytotoxicity, DNA fragmentation and sister-chromatid exchange in Chinese hamster ovary cells exposed to the lipid peroxidation product 4-hydroxynonenal and homologous aldehydes

1986 • 150 citations

Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cells

1988 • 149 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium

1989 • 116 citations

Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?

1990 • 116 citations

Effects of 4-hydroxynonenal on adenylate cyclase and 5′-nucleotidase activities in rat liver plasma membranes

1985 • 114 citations

Hydroperoxide-Induced Diacylglycerol Formation and Protein Kinase C Activation in Vascular Endothelial Cells

1993 • 109 citations

In vitro detection of endothelial cell damage using 2-deoxy-D-3H-glucose: comparison with chromium 51, 3H-leucine, 3H-adenine, and lactate dehydrogenase.

1985 • 101 citations

Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids

1988 • 100 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Effect of 4-hydroxyalkenals on hepatic phosphatidylinositol-4,5-bisphosphate-phospholipase C

1990 • 66 citations

Effect of t-Butyl-hydroperoxide on Bradykinin-stimulated Changes in Cytosolic Calcium in Vascular Endothelial Cells

1989 • 63 citations

Mechanism of phospholipidosis in amiodarone pulmonary toxicity.

1989 • 56 citations

Detection of 4-hydroxynonenal as a product of lipid peroxidation in native ehrlich ascites tumor cells

1984 • 55 citations

An enzymatic method for the determination of dCMP in picomol amounts

1976 • 51 citations

Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes

1990 • 47 citations

Phosphatidic Acid Directly Activates Endothelial Cell Protein Kinase C

1993 • 47 citations

Agonist-induced activation of phospholipase D in bovine pulmonary artery endothelial cells: regulation by protein kinase C and calcium.

1993 • 41 citations

Stimulation of phospholipase C activity by 4-hydroxynonenal; influence of GTP and calcium concentration.

1988 • 28 citations

Signal Transduction in Pulmonary Endothelium

1992 • 19 citations

Selective inhibition by 4-hydroxynonenal of sphingosine-stimulated phospholipase D in NIH 3T3 cells

1992 • 12 citations