Experimental liver cirrhosis induced by alcohol and iron.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Determination of malonaldehyde precursor in tissues by thiobarbituric acid test

1978 • 4,931 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis

1986 • 670 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes

1982 • 614 citations

Construction of DNA sequences complementary to rat .alpha.1 and .alpha.2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D

1984 • 568 citations

A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues

1981 • 520 citations

Hepatic lipid peroxidation in vivo in rats with chronic iron overload.

1983 • 399 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

Stimulation of Lipid Peroxidation or 4-Hydroxynonenal Treatment Increases Procollagen α1 (I) Gene Expression in Human Liver Fat-Storing Cells

1993 • 337 citations

Stimulation of Collagen Gene Expression by Ascorbic Acid in Cultured Human Fibroblasts

1989 • 312 citations

Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis

1990 • 295 citations

Ethanol-induced liver fibrosis in rats fed high fat diet

1986 • 279 citations

Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis

1992 • 235 citations

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

1992 • 228 citations

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride— and iron-dependent microsomal lipid peroxidation

1992 • 212 citations

Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis–dependent mechanism

1991 • 185 citations

Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: Status report

1990 • 180 citations

Pathology of dietary carbonyl iron overload in rats.

1987 • 152 citations

Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation.

1994 • 152 citations

Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis

1993 • 151 citations

Effect of Ethanol on Cytochrome P450 2E1 (CYP2E1), Lipid Peroxidation, and Serum Protein Adduct Formation in Relation to Liver Pathology Pathogenesis

1993 • 144 citations

Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.

1987 • 143 citations

d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation.

1991 • 124 citations

Regulation of Hepatic Microsomal Cytochrome P450IIE1 Level by Dietary Lipids and Carbohydrates in Rats

1991 • 112 citations

STORAGE IRON IN MAN.

1964 • 98 citations

Oxidative stress, antioxidants, and alcoholic liver fibrogenesis

1993 • 98 citations

Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation

1995 • 93 citations

Spin-trapping studies of hepatic free radicals formed following the acute administration of ethanol to rats: In vivo detection of 1-hydroxyethyl radicals with PBN

1991 • 81 citations

Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism, ,

1991 • 77 citations

Changes in Cytochromes P‐450, 2E1, 2B1, and 4A, and Phospholipases A and C in the Intragastric Feeding Rat Model for Alcoholic Liver Disease: Relationship to Dietary Fats and Pathologic Liver Injury

1994 • 74 citations

Effects of Dietary Fat Composition on Activities of the Microsomal Ethanol Oxidizing System and Ethanol‐Inducible Cytochrome P450 (CYP2E1) in the Liver of Rats Chronically Fed Ethanol

1992 • 71 citations

The Relation of Portal Cirrhosis to Hemochromatosis and to Diabetes Mellitus

1955 • 66 citations

Role of Superoxide and Trace Transition Metals in the Production of α-Hydroxyethyl Radical from Ethanol by Microsomes from Alcohol Dehydrogenase-Deficient Deermice

1993 • 64 citations

Detection of 4-hydroxynonenal and other lipid peroxidation products in the liver of bromobenzene-poisoned mice

1986 • 62 citations

Sublethal oxidant stress induces a reversible increase in intracellular calcium dependent on NAD(P)H oxidation in rat alveolar macrophages

1992 • 38 citations

Inhibition by 5-sulphosalicylic acid of the glutathione reductase recycling assay for glutathione analysis

1987 • 34 citations

The Genotoxic Effects of Arachidonic Acid in V79 Cells Are Mediated by Peroxidation Products

1993 • 9 citations