Chemistry and pathophysiology of oxidation of LDL

Beyond Cholesterol

1989 • 6,533 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

1993 • 1,665 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

1991 • 786 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects.

1991 • 727 citations

Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein

1993 • 710 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.

1989 • 594 citations

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

1993 • 512 citations

The kinetics of the autoxidation of polyunsaturated fatty acids

1987 • 507 citations

A site-specific mechanism for free radical induced biological damage: The essential role of redox-active transition metals

1988 • 505 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size

1992 • 474 citations

Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism.

1987 • 473 citations

High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.

1992 • 471 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

1992 • 463 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 406 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Membrane lipid oxidation

1990 • 389 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

The Role of Oxygen Radicals in Human Disease, with Particular Reference to the Vascular System

1993 • 371 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Improved Measurement of Low-Density-Lipoprotein Susceptibility to Copper-Induced Oxidation: Application of a Short Procedure for Isolating Low-Density Lipoprotein

1992 • 352 citations

Modified forms of low density lipoprotein and atherosclerosis

1993 • 348 citations

Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.

1994 • 334 citations

Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C

1990 • 321 citations

[50] Rapid isolation of lipoproteins and assessment of their peroxidation by high-performance liquid chromatography postcolumn chemiluminescence

1994 • 313 citations

α-tocopherol consumption during low-density-lipoprotein oxidation

1990 • 312 citations

Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation

1992 • 309 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

[46] Methods to determine oxidation of low-density lipoproteins

1994 • 283 citations

Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor

1993 • 279 citations

Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation.

1993 • 275 citations

Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation

1994 • 269 citations

Intact human ceruloplasmin oxidatively modifies low density lipoprotein.

1994 • 265 citations

Induction of T-cell activation by oxidized low density lipoprotein.

1992 • 246 citations

Oxidized Low Density Lipoproteins: a Role in the Pathogenesis of Atherosclerosis in Diabetes?

1991 • 244 citations

LDL particle size distribution. Results from the Framingham Offspring Study.

1992 • 229 citations

Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.

1991 • 228 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

A Method for Defining the Stages of Low-Density Lipoprotein Oxidation by the Separation of Cholesterol and Cholesteryl Ester-Oxidation Products Using HPLC

1993 • 221 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 216 citations

Oxidation of low density lipoprotein by thiols: superoxide-dependent and -independent mechanisms.

1993 • 212 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Low density lipoprotein is saturable by pro‐oxidant copper

1994 • 206 citations

Involvement of 15-lipoxygenase in early stages of atherogenesis.

1994 • 196 citations

Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages.

1989 • 186 citations

Pyrrole formation from 4-hydroxynonenal and primary amines

1993 • 172 citations

Native and oxidized LDL enhances production of PDGF AA and the surface expression of PDGF receptors in cultured human smooth muscle cells.

1992 • 169 citations

Oxygenation of lipoproteins by mammalian lipoxygenases

1993 • 163 citations

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

1990 • 162 citations

Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity.

1994 • 161 citations

Role of endothelial cells and their products in the modification of low-density lipoproteins

1986 • 159 citations

Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions

1993 • 159 citations

Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content.

1994 • 158 citations

Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.

1990 • 153 citations

Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages.

1990 • 150 citations

Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a).

1993 • 150 citations

Role of lipoprotein-copper complex in copper catalyzed-peroxidation of low-density lipoprotein

1992 • 145 citations

Lipids and oxidised lipids in human atheroma and normal aorta

1993 • 145 citations

Interaction of low density lipoproteins with arterial proteoglycans The role of charge and sialic acid content

1985 • 139 citations

Transferable lipids in oxidized low-density lipoprotein stimulate plasminogen activator inhibitor-1 and inhibit tissue-type plasminogen activator release from endothelial cells.

1993 • 134 citations

Activated human monocytes oxidize low-density lipoprotein by a lipoxygenase-dependent pathway.

1990 • 132 citations

Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells.

1994 • 129 citations

Plasmalogen Phospholipids as Potential Protectors Against Lipid Peroxidation of Low-Density Lipoproteins

1994 • 123 citations

Dynamics of the oxidation of low density lipoprotein induced by free radicals

1993 • 123 citations

Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex.

1991 • 123 citations

Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL.

1994 • 117 citations

Mechanistic and genetic aspects of susceptibility of LDL to oxidation

1993 • 115 citations

Evidence for a concerted reaction between lipid hydroperoxides and polypeptides.

1992 • 115 citations

Oxidized low‐density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation ¹

1991 • 113 citations

Structure and Function of Apolipoproteins

1992 • 111 citations

Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors.

1992 • 110 citations

Analysis of plasma cholesterol oxidation products using gas- and high-performance liquid chromatography/mass spectrometry

1994 • 108 citations

Fatty Acid Composition of Low-Density Lipoprotein Influences Its Susceptibility to Autoxidation

1994 • 104 citations

The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages

1991 • 102 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation?

1993 • 101 citations

Involvement of Preexisting Lipid Hydroperoxides in Cu2+-Stimulated Oxidation of Low-Density Lipoprotein

1994 • 99 citations

Angiotoxicity and atherogenicity of cholesterol oxides

1991 • 96 citations

Interaction of α-tocopherol with copper and its effect on lipid peroxidation

1994 • 94 citations

Lipoproteins secreted by cultured rat hepatocytes contain the antioxidant 1-alk-1-enyl-2-acylglycerophosphoethanolamine

1990 • 90 citations

Possible involvement of myeloperoxidase in lipid peroxidation

1992 • 88 citations

The interaction of low density lipoproteins with arterial proteoglycans

1980 • 87 citations

Lipoprotein-mediated inhibition of endothelial cell production of platelet-derived growth factor-like protein depends on free radical lipid peroxidation.

1987 • 87 citations

Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper

1994 • 86 citations

Uptake, metabolism, and cytotoxicity of isomeric cholesterol-5,6-epoxides in rabbit aortic endothelial cells.

1991 • 81 citations

Role of leukotrienes in leukocyte adhesion following systemic administration of oxidatively modified human low density lipoprotein in hamsters.

1991 • 81 citations

Oxidized low‐density lipoprotein is chemotactic for arterial smooth muscle cells in culture

1990 • 80 citations

Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu+2 ions: Identification of major products and their effects

1991 • 78 citations

Structure elucidation of oxygenated lipids in human atherosclerotic lesions.

1992 • 77 citations

Protein kinase C inhibitors prevent impairment of endothelium-dependent relaxation by oxidatively modified LDL.

1993 • 77 citations

Probucol reduces plasma and aortic wall oxysterol levels in cholesterol fed rabbits independently of its plasma cholesterol lowering effect

1992 • 76 citations

The oxygenation of cholesterol esters by the reticulocyte lipoxygenase

1991 • 75 citations

Lipoprotein modification

1994 • 71 citations

Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol‐10 and polyunsaturated fatty acid content

1994 • 70 citations

Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein

1994 • 70 citations

Alteration of lysophosphatidylcholine content in low density lipoprotein after oxidative modification: relationship to endothelium dependent relaxation

1994 • 69 citations

5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein

1991 • 69 citations

The influence of medium components on Cu2+-dependent oxidation of low-density lipoproteins and its sensitivity to superoxide dismutase

1992 • 67 citations

Low-density lipoprotein subclasses and risk of coronary artery disease

1991 • 66 citations

Peroxidation of human blood lipoproteins induced by exogenous hypochlorite or hypochlorite generated in the system of “myeloperoxidase + H2O2 + Cl−”

1994 • 65 citations

Structural and functional changes in LDL after modification with both 4-hydroxynonenal and malondialdehyde

1993 • 62 citations

Organization of phosphatidylcholine and sphingomyelin in the surface monolayer of low density lipoprotein and lipoprotein(a) as determined by time-resolved fluorometry.

1992 • 62 citations

Identification of cholesterol‐bound aldehydes in copper‐oxidized low density lipoprotein

1992 • 61 citations

Suppression of endothelin-1 secretion by lysophosphatidylcholine in oxidized low density lipoprotein in cultured vascular endothelial cells.

1992 • 61 citations

Headspace gas chromatography to determine human low density lipoprotein oxidation

1992 • 60 citations

Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells.

1992 • 52 citations

Lipid antioxidants: how they may act in biological systems.

1987 • 50 citations

Oxidation of cholesteryl linoleate by human monocyte-macrophages in vitro

1990 • 49 citations

Evidence for the presence of 7-hydroperoxycholest-5-en-3β-ol in oxidized human LDL

1992 • 48 citations

Formation of monohydroxy derivatives of arachidonic acid, linoleic acid, and oleic acid during oxidation of low density lipoprotein by copper ions and endothelial cells.

1992 • 48 citations

Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor

1986 • 45 citations

Induction of Stress Proteins in Mouse Peritoneal Macrophages by Oxidized Low-Density Lipoprotein

1993 • 42 citations

Toxicity of oxygenated cholesterol derivatives toward cultured human umbilical vein endothelial cells.

1991 • 41 citations

Induction of platelet-derived growth factor chain a gene expression in human smooth muscle cells by oxidized low density lipoproteins

1992 • 41 citations

Vidarabin-monophosphate, BCNU, VM26 – an in vitro comparative study of active agents in the treatment of malignant human brain tumours

1987 • 39 citations

Biological consequences of oxidative stress; implications for cardiovascular disease and carcinogenesis

1993 • 37 citations

Oxidation of Low-Density Lipoproteins by OH· and ${\rm OH}\cdot /{\rm O}_{2}^{\overline{\cdot}}$ Free Radicals Produced by Gamma Radiolysis

1993 • 36 citations

Assessment of 5-lipoxygenase involvement in human monocyte-mediated LDL oxidation.

1993 • 36 citations

Effects of cholesterol and oxysterols on gap junctional communication between human smooth muscle cells

1992 • 35 citations

Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein

1990 • 33 citations

UV-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. 4. Calcium is involved in the cytotoxicity of UV-treated LDL on lymphoid cell lines

1992 • 32 citations

Modified Low-Density Lipoproteins: Diversity and Biological Relevance in Atherogenesis

2015 • 31 citations

Nutritional Assessment of Vitamin E in Oxidative Stress^a

1989 • 31 citations

Macrophage uptake of low-density lipoprotein modified by 4-hydroxynonenal. An ultrastructural study.

1991 • 28 citations

Free radicals, lipid peroxidation and atherosclerosis

1990 • 27 citations

NMR Analysis of Low-Density Lipoprotein Oxidatively-Modifiedin vztro

1990 • 23 citations

Oxygen radicals and atherosclerosis

1991 • 22 citations

A mechanistic study of the interaction of UVB radiations with human serum lipoproteins

1991 • 12 citations

Aldehydes from metal ion- and lipoxygenase-induced lipid peroxidation: detection by 1H-n.m.r. spectroscopy

1993 • 12 citations

Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production

1993 • 11 citations

Analytical Examination of Oxidized Free and Esterified 7-Ketocholesterol and Related Oxysterols in Human Plasma Incubated with Copper.

1992 • 8 citations

[Structure and function of apolipoproteins].

1994 • 8 citations