The role of lipid peroxidation and antioxidants in oxidative modification of LDL

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Beyond Cholesterol

1989 • 6,533 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury

1990 • 2,639 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Lycopene as the most efficient biological carotenoid singlet oxygen quencher

1989 • 2,238 citations

The Pathogenesis of Atherosclerosis

1976 • 2,000 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method

1979 • 1,477 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

1990 • 1,039 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

How to Characterize a Biological Antioxidant

1990 • 943 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Antioxidant functions of carotenoids

1989 • 916 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages

1980 • 851 citations

High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein

1990 • 836 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

The Role of Lipids and Lipoproteins in Atherosclerosis

1950 • 808 citations

Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene

1991 • 788 citations

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

1991 • 786 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

1988 • 757 citations

Vitamin E: Antioxidant Activity, Biokinetics, and Bioavailability

1990 • 739 citations

Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects.

1991 • 727 citations

Vitamin E: A Comprehensive Treatise

1980 • 720 citations

Antioxidants in relation to lipid peroxidation

1987 • 684 citations

THE LDL RECEPTOR LOCUS IN FAMILIAL HYPERCHOLESTEROLEMIA: Mutational Analysis of a Membrane Protein

1990 • 684 citations

Role of vitamin E in preventing the oxidation of low-density lipoprotein

1991 • 649 citations

Lipid Peroxides in Biology and Medicine

1982 • 640 citations

Probucol inhibits oxidative modification of low density lipoprotein.

1986 • 633 citations

Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology.

1989 • 630 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.

1989 • 594 citations

Autoxidative Glycosylation and Possible Involvement of Peroxides and Free Radicals in LDL Modification by Glucose

1990 • 561 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit) *1Incidence and development of atherosclerosis and xanthoma

1980 • 540 citations

Biochemical structural and functional properties of oxidized low-density lipoprotein

1990 • 536 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 • 510 citations

The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis

1986 • 492 citations

Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid

1991 • 485 citations

A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein

1989 • 480 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.

1991 • 477 citations

Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages.

1980 • 475 citations

Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism.

1987 • 473 citations

The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.

1981 • 468 citations

Vitamin E and oxidative stress

1991 • 461 citations

Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.

1990 • 461 citations

Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II

1990 • 460 citations

Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer

1987 • 436 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 406 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Membrane lipid oxidation

1990 • 389 citations

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

1985 • 388 citations

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.

1989 • 380 citations

Presence of a modified low density lipoprotein in humans.

1988 • 373 citations

Lipid peroxides and atherosclerosis.

1989 • 366 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

STUDIES ON THE ROLE OF LIPOPEROXIDES IN HUMAN PATHOLOGY

1952 • 347 citations

Lipid peroxidation and endothelial cell injury: implications in atherosclerosis

1988 • 335 citations

The fine structure of human atherosclerotic lesions.

1961 • 335 citations

On the cytotoxicity of vitamin C and metal ions

1983 • 328 citations

Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C

1990 • 321 citations

Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the Apoproteins

1979 • 313 citations

Stimulation of Collagen Gene Expression by Ascorbic Acid in Cultured Human Fibroblasts

1989 • 312 citations

α-tocopherol consumption during low-density-lipoprotein oxidation

1990 • 312 citations

Lipid peroxide levels of serum lipoprotein fractions of diabetic patients

1981 • 305 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein

1990 • 297 citations

Value, sensitivity and specificity of stroke volume ratio in routine equilibrium gated scintigraphy

1987 • 297 citations

Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation

1989 • 294 citations

Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins.

1982 • 279 citations

Autoxidation of unsaturated lipids

1986 • 279 citations

Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells

1991 • 275 citations

Superoxide initiates oxidation of low density lipoprotein by human monocytes.

1987 • 273 citations

The role of iron in the initiation of lipid peroxidation

1987 • 268 citations

Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis.

1990 • 266 citations

Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.

1989 • 265 citations

Effect of Antioxidants on Oxidative Modification of LDL

1991 • 263 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100.

1987 • 254 citations

Effect of polyunsaturated fatty acids and antioxidants on lipid peroxidation in tissue cultures.

1981 • 252 citations

Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.

1989 • 250 citations

Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal

1986 • 241 citations

Plasma Vitamins E and A Inversely Correlated to Mortality from Ischemic Heart Disease in Cross‐Cultural Epidemiology

1989 • 240 citations

Effects of d-alpha-tocopherol supplementation on experimentally induced primate atherosclerosis.

1992 • 240 citations

Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor

1987 • 236 citations

Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay

1989 • 234 citations

Superoxide anion participation in human monocyte-mediated oxidation of low-density lipoprotein and conversion of low-density lipoprotein to a cytotoxin.

1989 • 231 citations

Medical, biochemical and chemical aspects of free radicals

1990 • 229 citations

Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells.

1991 • 228 citations

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

1991 • 228 citations

Role of superoxide in endothelial-cell modification of low-density lipoproteins

1988 • 228 citations

β-Carotene inhibits the oxidative modification of low-density lipoprotein

1991 • 227 citations

Free radicals in iron-containing systems

1987 • 225 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

Macrophage-derived foam cells freshly isolated from rabbit atherosclerotic lesions degrade modified lipoproteins, promote oxidation of low-density lipoproteins, and contain oxidation-specific lipid-protein adducts.

1991 • 219 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 216 citations

Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophages.

1984 • 213 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Interactions of serum copper, selenium, and low density lipoprotein cholesterol in atherogenesis.

1991 • 210 citations

α-Tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity

1991 • 209 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?

1983 • 205 citations

The Role of Vitamin E and Carotenoids in Preventing Oxidation of Low Density Lipoproteins^a

1989 • 201 citations

Lipid peroxide levels and lipid content of serum lipoprotein fractions of pregnant subjects with or without pre-eclampsia

1981 • 196 citations

Tocopherol, oxygen and biomembranes

1978 • 194 citations

Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages

1989 • 191 citations

Effects of d-α-Tocopherol Supplementation on Experimentally Induced Primate Atherosclerosis

1992 • 188 citations

Lysophosphatidylcholine: Essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein

1990 • 187 citations

Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages.

1989 • 186 citations

Scavenging for receptors

1990 • 184 citations

Native and oxidized low‐density lipoproteins have different inhibitory effects on endothelium‐derived relaxing factor in the rabbit aorta

1990 • 183 citations

Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins.

1991 • 177 citations

Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose

1990 • 177 citations

Low density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes. A possible mechanism of foam cell formation.

1988 • 174 citations

Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor.

1987 • 171 citations

The oxidative modification of low-density lipoproteins by macrophages

1990 • 169 citations

The action of defined oxygen-centred free radicals on human low-density lipoprotein

1989 • 167 citations

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

1990 • 162 citations

Differential uptake of proteoglycan-selected subfractions of low density lipoprotein by human macrophages.

1990 • 162 citations

Role of endothelial cells and their products in the modification of low-density lipoproteins

1986 • 159 citations

Strategies for the prevention of coronary heart disease: A policy statement of the European Atherosclerosis Society

1987 • 156 citations

Expression of the acetyl low density lipoprotein receptor by rabbit fibroblasts and smooth muscle cells. Up-regulation by phorbol esters.

1990 • 155 citations

Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.

1990 • 153 citations

Free radical modification of low-density lipoprotein: Mechanisms and biological consequences

1987 • 150 citations

Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract.

1988 • 147 citations

Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

1991 • 147 citations

Multiple receptors for modified low density lipoproteins in mouse peritoneal macrophages : different uptake mechanisms for acetylated and oxidized low density lipoproteins

1991 • 145 citations

Über den Gehalt normaler und atheromatöser Aorten an Cholesterin und Cholesterinestern.

1910 • 144 citations

Isolation and characterization of a complement-activating lipid extracted from human atherosclerotic lesions.

1990 • 144 citations

Probucol attenuates the development of aortic atherosclerosis in cholesterol‐fed rabbits

1989 • 142 citations

Varying susceptibility of different low density lipoproteins to oxidative modification.

1991 • 140 citations

A Rapid Method for the Bulk Isolation of β-Lipoproteins from Human Plasma¹

1957 • 139 citations

Oxidation of lipoprotein Lp(a). A comparison with low-density lipoproteins

1991 • 137 citations

Vitamin E content and low density lipoprotein oxidizability induced by free radicals

1990 • 137 citations

Elevated serum neopterin levels in atherosclerosis

1991 • 137 citations

Isolation of low density lipoprotein from atherosclerotic vascular tissue of Watanabe heritable hyperlipidemic rabbits.

1988 • 135 citations

Isolation, purification, and characterization of a lipoprotein containing apo B from the human aorta

1982 • 135 citations

A simple test for predisposition to LDL oxidation based on the fluorescence development during copper-catalyzed oxidative modification.

1991 • 135 citations

Vitamin E and other Lipophilic Antioxidants Protect LDL against Oxidation

1989 • 134 citations

A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit.

1984 • 127 citations

17 Beta-Estradiol Inhibits LDL Oxidation and Cholesteryl Ester Formation in Cultured Macrophages

1990 • 126 citations

Plasma tocopherol concentrations in response to supplemental vitamin E

1991 • 124 citations

Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status

1991 • 124 citations

d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation.

1991 • 124 citations

Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex.

1991 • 123 citations

Interactions of the Polar Groups of Phospholipid Bilayer Membranes

1979 • 123 citations

Interaction of α-tocopherol with iron: antioxidant and prooxidant effects of α-tocopherol in the oxidation of lipids in aqueous dispersions in the presence of iron

1988 • 120 citations

Megavitamin E supplementation in man

1975 • 118 citations

Occurrence of 4-hydroxyalkenals in rat tissues determined as pentafluorobenzyl oxime derivatives by gas chromatography-mass spectrometry

1986 • 117 citations

Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC

1991 • 117 citations

Antioxidant activity of probucol and its analogs in hypercholesterolemic Watanabe rabbits

1991 • 116 citations

Oxidized low‐density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation ¹

1991 • 113 citations

Toxicity of oxidized low‐density lipoprotein to cultured fibroblasts is selective for S phase of the cell cycle

1987 • 112 citations

Hyperlipoproteinemia

1954 • 108 citations

Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation.

1989 • 107 citations

Attenuation of atherosclerosis in a modified strain of hypercholesterolemic Watanabe rabbits with use of a probucol analogue (MDL 29,311) that does not lower serum cholesterol.

1991 • 106 citations

Do antioxidants and polyunsaturated fatty acids have a combined association with coronary atherosclerosis?

1991 • 105 citations

Hypocholesterolesmic Effect of 4,4′-(Isopropylidenedithio)-Bis(2,6-di-t-Butylphenol) (Probucol)

1970 • 103 citations

Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels

1989 • 102 citations

The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages

1991 • 102 citations

Formation of 15-HETE as a major hydroxyeicosatetraenoic acid in the atherosclerotic vessel wall

1985 • 102 citations

Free Radicals, Lipoproteins, and Membrane Lipids

1990 • 102 citations

Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages.

1985 • 101 citations

Characterization of two lipoproteins containing apolipoproteins B and E from lesion-free human aortic intima.

1988 • 100 citations

Vitamin E, Antioxidants and Lipid Peroxidation in Experimental Atherosclerosis of Rabbits

1978 • 100 citations

LDL-induced cytotoxicity and its inhibition by anti-oxidant treatment in cultured human endothelial cells and fibroblast

1983 • 100 citations

Studies on the distribution of tocopherol in human serum lipoproteins

1960 • 98 citations

HDL-cholesterol, apolipoproteins A1 and B

1978 • 98 citations

Lipoprotein-antibody immune complexes their catabolism and role in foam cell formation

1985 • 97 citations

Malondialdehyde formation in stored plasma

1980 • 97 citations

Lipids of human atheroma. 8. Oxidised derivatives of cholesteryl linoleate.

1973 • 95 citations

Inhibition of IL-1β expression in THP-1 cells by probucol and tocopherol

1991 • 94 citations

Endogenous antioxidants and lipoprotein oxidation

1990 • 93 citations

Free radical modification of lipoproteins and cholesterol accumulation in cells upon atherosclerosis

1991 • 93 citations

Quantitative evaluation of vitamin E in the treatment of angina pectoris

1977 • 91 citations

Age-Dependent Changes in Lipid Peroxide Levels in the Lipoprotein Fractions of Human Serum

1984 • 91 citations

Effect of probucol on the physical properties of low-density lipoproteins oxidized by copper

1989 • 90 citations

Lipoproteins secreted by cultured rat hepatocytes contain the antioxidant 1-alk-1-enyl-2-acylglycerophosphoethanolamine

1990 • 90 citations

Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries.

1980 • 89 citations

Kinetics of transfer of α-tocopherol between model and native plasma lipoproteins

1984 • 89 citations

Absorption and transport of deuterium‐substituted 2R,4′R,8′R‐α‐tocopherol in human lipoproteins

1988 • 88 citations

Autoantibodies against modified low density lipoprotein. Nonlipid factor of blood plasma that stimulates foam cell formation.

1991 • 88 citations

Lipid peroxidation in biological systems

1989 • 86 citations

Determination of right ventricular mass in humans and dogs with ultrafast cardiac computed tomography.

1990 • 83 citations

Experiments on the Degradation of Lipoproteins from Serum

1954 • 83 citations

Lipid peroxide and transition metals are required for the toxicity of oxidized low density lipoprotein to cultured endothelial cells

1991 • 83 citations

Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways

1991 • 82 citations

Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content

1991 • 82 citations

Role of leukotrienes in leukocyte adhesion following systemic administration of oxidatively modified human low density lipoprotein in hamsters.

1991 • 81 citations

Detection of new epitopes formed upon oxidation of low-density lipoprotein, lipoprotein (a) and very-low-density lipoprotein. Use of an antiserum against 4-hydroxynonenal-modified low-density lipoprotein

1990 • 80 citations

Oxidized low‐density lipoprotein is chemotactic for arterial smooth muscle cells in culture

1990 • 80 citations

Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu+2 ions: Identification of major products and their effects

1991 • 78 citations

Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography

1991 • 75 citations

The oxygenation of cholesterol esters by the reticulocyte lipoxygenase

1991 • 75 citations

Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits.

1991 • 73 citations

Sterol metabolism

1970 • 72 citations

Formation of 15-hydroxyeicosatetraenoic acid (15-HETE) as the predominant eicosanoid in aortas from Watanabe Heritable Hyperlipidemic and cholesterol-fed rabbits

1989 • 72 citations

Therapeutic potential of vitamin E against myocardial ischemic-reperfusion injury

1991 • 71 citations

Oxidative modification of low density lipoprotein (LDL) by activated human monocytes and the cell lines U937 and HL60

1988 • 71 citations

Cholesterol Metabolism, Ldl, and the Ldl Receptor

1990 • 70 citations

5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein

1991 • 69 citations

Fractionation of charge-modified low density lipoproteins by fast protein liquid chromatography.

1991 • 68 citations

Iodometric measurement of lipid hydroperoxides in human plasma

1991 • 68 citations

LIPID PEROXIDES AS A CAUSE OF VASCULAR DISEASES

1982 • 67 citations

Eicosanoids, Lipid Peroxidation and Cancer

1988 • 66 citations

Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E

1989 • 66 citations

Modified plasma-derived lipoproteins in human atherosclerotic plaques

1988 • 65 citations

Effect of dietary vitamin E on plasma lipids and atherogenesis in restricted ovulator chickens

1989 • 63 citations

Sensitivity of tryptophan and related compounds to oxidation induced by lipid autoperoxidation. Application to human serum low- and high-density lipoproteins

1990 • 63 citations

Evidence for lipid peroxidation in atherosclerosis

1990 • 62 citations

Plasma lipoprotein peroxidation potential: a test to evaluate individual susceptibility to peroxidation

1991 • 62 citations

Lipids of human atheroma

1973 • 62 citations

Macrophages, Endothelial Cells, and Lipoprotein Oxidation in the Pathogenesis of Atherosclerosis*

1990 • 57 citations

Fatty acid metabolism and cell proliferation: IV. Effect of prostanoid biosynthesis from endogenous fatty acid release with cyclosporin‐A

1983 • 57 citations

The origin of foam cells in atherosclerosis.

1971 • 57 citations

Prevention of atherosclerotic progression in Watanabe rabbits by probucol

1988 • 57 citations

Some questions concerning a small, more electronegative LDL circulating in human plasma

1991 • 57 citations

PROGRESS OF MEDICAL SCIENCE PATHOLOGY AND BACTERIOLOGY UNDER THE CHARGE OF

1965 • 55 citations

Modifications of low-density lipoprotein induced by arterial proteoglycans and chondroitin-6-sulfate

1991 • 55 citations

Oxidative modification of glycated low density lipoprotein in the presence of iron

1991 • 55 citations

Neutron small angle scattering on selectively deuterated human plasma low density lipoproteins. The location of polar phospholipid headgroups.

1981 • 55 citations

Increased levels of monohydroxy metabolites of arachidonic acid and linoleic acid in LDL and aorta from atherosclerotic rabbits

1991 • 54 citations

İron binding to microsomes and liposomes in relation to lipid peroxidation

1987 • 53 citations

A double-blind trial of vitamin E in angina pectoris1,2

1974 • 53 citations

Oxidation of low-density lipoprotein by copper and iron in phosphate buffer

1991 • 52 citations

Oxidation of cholesteryl linoleate by human monocyte-macrophages in vitro

1990 • 49 citations

Serum malondialdehyde-like material (MDA-LM) in acute myocardial infarction.

1983 • 49 citations

Lipoprotein oxidation and cytotoxicity: Effect of probucol on streptozotocin-treated rats

1988 • 49 citations

Investigation of human plasma low density lipoprotein by three‐dimensional flourescence spectroscopy

1986 • 49 citations

Oxidation of low-density lipoprotein by Cu2+ and lipoxygenase: an electron spin resonance study

1990 • 48 citations

The interaction of carbamylated low-density lipoprotein with cultured cells

1983 • 48 citations

Properties of lipoprotein complexes isolated by affinity chromatography from human aorta.

1985 • 48 citations

Erythrocyte-bound low-density lipoprotein immune complexes lead to cholesteryl ester accumulation in human monocyte-derived macrophages

1991 • 48 citations

Free and complexed anti-lipoprotein antibodies in vascular diseases

1983 • 47 citations

Immunological detection of low-density lipoproteins modified by malondialdehyde in vitro or in vivo

1987 • 46 citations

Effects of elevated d-alpha (RRR)-tocopherol dosage in man.

1989 • 45 citations

Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor

1986 • 45 citations

In Vitro Uptake of [3H]α-Tocopherol from Low Density Lipoprotein by Cultured Human Fibroblasts

1985 • 43 citations

Uptake and degradation of low density lipoproteins in atherosclerotic rabbit aorta: role of local LDL modification.

1991 • 43 citations

Fettlösliche Vitamine und Atherosklerose

1956 • 42 citations

Phagocytes, lipid‐removal and regression of atheroma

1975 • 42 citations

Fatty acid metabolism and cell proliferation. VII. Antioxidant effects of tocopherols and their quinones

1985 • 39 citations

Monoclonal DLR1a/104G antibody recognizing peroxidized lipoproteins in atherosclerotic lesions

1988 • 39 citations

Investigation of Lipid Peroxidation in Human Low Density Lipoprotein

1987 • 37 citations

An immunochemical marker of low density lipoprotein oxidation.

1989 • 35 citations

Cardiomyopathy associated with vitamin E deficiency in seven gelada baboons.

1984 • 35 citations

Phenothiazines inhibit copper and endothelial cell-induced peroxidation of low density lipoprotein

1990 • 33 citations

Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein

1990 • 33 citations

Anti-oxidant supplementation decreases TBA reactants in serum of elderly

1988 • 32 citations

Cu2(+)-mediated oxidation of dialyzed plasma: effects on low and high density lipoproteins and cholesteryl ester transfer protein.

1991 • 31 citations

Nutritional Assessment of Vitamin E in Oxidative Stress^a

1989 • 31 citations

Site-specific mechanisms of initiation by chelated iron and inhibition by α-tocopherol of lipid peroxide-dependent lipid peroxidation in charged micelles

1991 • 31 citations

The effect of [4,4′-(isopropylidenedithio)bis(2,6-di-t-butylphenol)] (DH-581) on serum lipids and lipoproteins in human subjects

1969 • 30 citations

Increased plasma and erythrocyte lipid peroxidation in hyperlipidemic individuals

1989 • 30 citations

Antioxidants and resistance against oxidation of porcine LDL subfractions.

1990 • 30 citations

Immunogenicity of malondialdehyde-modified low density lipoproteins

1987 • 29 citations

Calcium Antagonists Prevent Monocyte and Endothelial Cell-Induced Modification of Low Density Lipoproteins

1991 • 29 citations

Occurrence of anti-low density lipoprotein antibodies and circulating immune complexes in aged subjects

1985 • 29 citations

Oxidation of beta-very low density lipoprotein by endothelial cells enhances its metabolism by smooth muscle cells in culture.

1991 • 27 citations

Free radicals, lipid peroxidation and atherosclerosis

1990 • 27 citations

Changes of apolipoprotein B molecular weight and immunoreactivity in malondialdehyde-modified low density lipoproteins.

1983 • 25 citations

Introduction—The probucol experience: A review of the past and a look at the future

1988 • 25 citations

Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits.

1989 • 24 citations

Pharmacology of lipid transport and atherosclerotic processes

1975 • 24 citations

NMR Analysis of Low-Density Lipoprotein Oxidatively-Modifiedin vztro

1990 • 23 citations

Effects of oxidized low density lipoproteins on arachidonic acid metabolism in smooth muscle cells.

1990 • 22 citations

Studies on oxidized low density lipoproteins. Controlled oxidation and a prostaglandin artifact.

1989 • 22 citations

Antiatherosclerotic effect of probucol in WHHL rabbits: are there plasma parameters to evaluate this effect?

1991 • 21 citations

Lipoprotein degradation and cholesterol esterification in primary cell cultures of rabbit atherosclerotic lesions.

1990 • 17 citations

Effect of linoleic acid hydroperoxide on uptake of low density lipoprotein by cultured smooth muscle cells from rabbit aorta.

1984 • 17 citations

Konzentration Thiobarbitursäure-reaktiver Substanzen (TBARS) im Serum nach Myokardinfarkt

1986 • 16 citations

Plasma lipid peroxidation in hyperlipidemic chickens

1985 • 16 citations

The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis *1Part 2. Studies on “nile blue” cells

1972 • 15 citations

Effects of oxygen-centred free radicals on low-density lipoprotein structure and metabolism

1987 • 15 citations

Antioxidant activity of probucol and its effects on phase transitions in phosphatidylcholine liposomes

1990 • 14 citations

Probucol does not affect lipoprotein metabolism in macrophages of Watanabe heritable hyperlipidemic rabbits.

1989 • 14 citations

Comparison of apoprotein B of low density lipoproteins of human interstitial fluid and plasma

1984 • 13 citations

[Study of lipid peroxidation by the assay of malondialdehyde in human and experimental atheroma].

1986 • 13 citations

Effects of mildly oxidized low-density lipoprotein on endothelial cell function

1991 • 12 citations

Effect of Peroxidative Conditions on Human Plasma Low-Density Lipoproteins

1988 • 10 citations

Lipoprotein immune complexes and their role in atherogenesis

1991 • 10 citations

Antioxidant Therapy and Uptake of Human Oxidized LDL by Macrophages

1989 • 10 citations

Electron spin resonance spin-trapping study of peroxidation of human low density lipoprotein

1988 • 9 citations

Incides of lipid peroxidation in patients with hypercholesterolemia and hypertriglyceridemia.

1989 • 9 citations

Prevention and regression of primate atherosclerosis by d-alpha tocopherol

1990 • 9 citations

Chapter 2 The complete structures of human apolipoprotein B-100 and its messenger RNA

1987 • 9 citations

Isolation and Partial Characterization of an Oxidized LDL in Humans

1988 • 7 citations

Cholesterol Metabolism, LDL, and the LDL Receptor

1991 • 6 citations

Paradoxical Effects of Vitamin E: Oxidized Lipoproteins, Prostanoids and the Pathogenesis of Atherosclerosis

1990 • 5 citations

Alpha-Tocopherol: A Potent Inhibitor of Platelet Adhesion

1992 • 5 citations

Comparison among lipid constituents in native LDL, ultra-water-soluble LDL, and vessel wall, and their significance in arteriosclerosis

1987 • 4 citations

Epr Evidence for the Oxidation-Induced Formation of Negatively Charged Species on the Low-Density Lipoprotein Surface

1991 • 4 citations

Spatial organization of low-density lipoproteins of the human aorta (a fluorescent probe study)

1983 • 4 citations

Role of Low Density Lipoprotein Oxidation in Foam Cell Formation

1990 • 3 citations

The Role of Oxidative Metabolism and Antioxidants in Low-Density Lipoprotein Structure and Metabolism

1990 • 3 citations

Plasma Lipid Peroxidation and Atherosclerosis in Restricted Ovulator Chickens

1988 • 2 citations

CHEMISTRY OF OXIDATION OF LOW DENSITY LIPOPROTEINS

1991 • 2 citations

Deleted Work

1955 • 0 citations