Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?

Beyond Cholesterol

1989 • 6,533 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

Identification of procollagen mRNAs transferred to diazobenzyloxymethyl paper from formaldehyde agarose gels

1979 • 564 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

1990 • 432 citations

Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

1989 • 401 citations

Hepatic lipid peroxidation in vivo in rats with chronic iron overload.

1983 • 399 citations

Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis.

1990 • 354 citations

Maintenance of Differentiated Phenotype of Cultured Rat Hepatic Lipocytes by Basement Membrane Matrix

1989 • 353 citations

Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization

1990 • 323 citations

Stimulation of Collagen Gene Expression by Ascorbic Acid in Cultured Human Fibroblasts

1989 • 312 citations

The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis.

1985 • 267 citations

The synthesis of proteoglycans in fat-storing cells of rat liver

1987 • 259 citations

Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload.

1990 • 244 citations

Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes.

1990 • 237 citations

Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis.

1992 • 230 citations

Cell types involved in collagen and fibronectin production in normal and fibrotic human liver

1986 • 229 citations

Isolated and cultured hepatocytes

1986 • 222 citations

Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine.

1984 • 172 citations

Malondialdehyde formation from lipid peroxides in the thiobarbituric acid test: the role of lipid radicals, iron salts, and metal chelators.

1983 • 162 citations

Role of alcohol dehydrogenase activity and the acetaldehyde in ethanol- induced ethane and pentane production by isolated perfused rat liver

1982 • 146 citations

Isolation and characterization of the rat α1(I) collagen promoter

1989 • 145 citations

Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.

1990 • 144 citations

Acetaldehyde increases collagen gene transcription in cultured human fibroblasts.

1987 • 143 citations

Long‐term maintenance of hepatocyte functional activity in co‐culture: Requirements for sinusoidal endothelial cells and dexamethasone

1986 • 140 citations

Bleomycin-induced Pulmonary Fibrosis in Rats: Biochemical Demonstration of Increased Rate of Collagen Synthesis^1,2

1980 • 138 citations

Transcriptional switch from albumin to .alpha.-fetoprotein and changes in transcription of other genes during carbon tetrachloride-induced liver regeneration

1986 • 135 citations

Generation of a chemotactic lipid from arachidonic acid by exposure to a superoxide-generating system

1980 • 134 citations

Increased procollagen mRNA levels in carbon tetrachloride-induced liver fibrosis in rats.

1987 • 131 citations

Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels.

1987 • 127 citations

d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation.

1991 • 124 citations

Synthesis in vitro of Keratin Polypeptides Directed by mRNA Isolated from Newborn and Adult Mouse Epidermis

1980 • 106 citations

Collagen Formation by the Hepatocyte in Primary Monolayer Culture and in Vivo

1983 • 105 citations

Detection of carbonyl functions in phospholipids of liver microsomes in CCl4- and BrCCl3-poisoned rats

1982 • 75 citations

Increased production of collagenin Vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis

1988 • 73 citations

Relationship of oxygen and glutathione in protection against carbon tetrachloride-induced hepatic microsomal lipid peroxidation and covalent binding in the rat. Rationale for the use of hyperbaric oxygen to treat carbon tetrachloride ingestion.

1984 • 73 citations

Therapeutic strategies for hepatic fibrosis

1988 • 72 citations

Mechanism of hepatotoxicity to periportal regions of the liver lobule due to allyl alcohol: role of oxygen and lipid peroxidation.

1986 • 65 citations

Transcriptional regulation of type I collagen genes in cultured fibroblasts by a factor isolated from thioacetamide-induced fibrotic rat liver.

1984 • 59 citations

Hepatocyte collagen production in vivo in normal rats.

1986 • 58 citations

Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4-induced lipid peroxidation in rat liver and its significance for hepatoprotection

1989 • 46 citations

Reversible inhibition of albumin production by rat hepatocytes maintained on a laminin-rich gel (Engelbreth-Holm-Swarm) in response to secretory products of Kupffer cells and cytokines

1992 • 42 citations

Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachloride

1988 • 40 citations

Isolated and Cultured Hepatocytes. Herausgegeben von A. Guillouzo und Chr. Guguen‐Guillouzo. 408 Seiten, 93 Abb., 27 Tab. Les Editions INSERM, Paris, und John Libbey & Company Ltd, London/John Libbey Eurotext Ltd, Montrouge, 1986

1987 • 36 citations

Rates of allyl alcohol metabolism in periportal and pericentral regions of the liver lobule.

1984 • 35 citations

Pathogenesis and Treatment of Photocutaneous Manifestations of the Porphyrias

1982 • 35 citations

Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol.

1991 • 31 citations

Characterization of a new monoclonal antibody to rat macrophages and Kupffer cells

1988 • 19 citations

Isolation and characterization of a fibrogenic factor from CCl4-damaged rat liver

1982 • 14 citations

Bioluminescence Assays for Bile Acids in the Detection and Follow-Up of Experimental Liver Injury

1984 • 9 citations

Comparative hepatic response to bromobenzene and allyl alcohol in the vitamin D-replete and vitamin D-depleted rat.

1985 • 5 citations