4-Hydroxynonenal, a Lipid Peroxidation Product, Induces Relaxation of Human Cerebral Arteries

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Superoxide anion is an endothelium-derived contracting factor

1989 • 398 citations

Membrane lipid oxidation

1990 • 389 citations

Redox control of enzyme activities by thiol/disulfide exchange

1984 • 264 citations

In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle.

1993 • 189 citations

Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery

1993 • 109 citations

Cytotoxicities of a linoleic acid hydroperoxide and its related aliphatic aldehydes toward cultured human umbilical vein endothelial cells

1988 • 100 citations

Determination of the lipid peroxidation product trans-4-hydroxy-2-nonenal in biological samples by high-performance liquid chromatography and combined capillary column gas chromatography—negative-ion chemical ionisation mass spectrometry

1989 • 89 citations

Activation of rat brain protein kinase C by lipid oxidation products

1988 • 83 citations

Potentiation of norepinephrine-induced contractions by endothelin-1 in the rabbit aorta.

1993 • 75 citations

4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells

1993 • 75 citations

Protein kinase C‐mediated contractile responses of arteries from diabetic rats

1990 • 71 citations

Effect of 4-hydroxyalkenals on hepatic phosphatidylinositol-4,5-bisphosphate-phospholipase C

1990 • 66 citations

Effects of free radical generation on mouse pial arterioles: probable role of hydroxyl radicals

1983 • 66 citations

Effect of oxidant stress in calcium signaling in vascular endothelial cells

1992 • 64 citations

Role of endothelium and calcium channels in endothelin‐induced contraction of human cerebral arteries

1990 • 52 citations

Lipid hydroperoxides potentiate mesenteric artery vasoconstrictor responses

1993 • 34 citations

Cumene hydroperoxide, an agent inducing lipid peroxidation, and 4-hydroxy-2,3-nonenal, a peroxidation product, cause coronary vasodilatation in perfused rat hearts by a cyclic nucleotide independent mechanism

1990 • 26 citations

Triphasic vascular effects of thiol compounds and their oxidized forms on dog coronary arteries

1993 • 11 citations