Prospective therapeutic applications of p53 inhibitors

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

The p53 pathway

1999 • 1,322 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

2001 • 713 citations

Understanding cell death in parkinson's disease

1998 • 678 citations

Doxorubicin Induces Apoptosis in Normal and Tumor Cells via Distinctly Different Mechanisms

2004 • 578 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

Rescuing the function of mutant p53

2001 • 563 citations

The role of p53 in determining sensitivity to radiotherapy

2003 • 549 citations

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

1999 • 384 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Bax Involvement in p53-Mediated Neuronal Cell Death

1998 • 337 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Regulation of p53 Function

2001 • 319 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide

2001 • 315 citations

p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

2000 • 272 citations

Transgenic mice with p53-responsive lacZ: p53activity varies dramatically during normal development and determines radiation and drug sensitivity invivo

1997 • 270 citations

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice

2004 • 231 citations

p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.

1993 • 229 citations

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

1997 • 227 citations

P53 Mediates the Apoptotic Response to GTP Depletion after Renal Ischemia-Reperfusion

2003 • 223 citations

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

2002 • 202 citations

Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis

2002 • 199 citations

P53- and CD95-associated apoptosis in neurodegenerative diseases.

1998 • 196 citations

Progressively developed myocardial apoptotic cell death during late phase of reperfusion.

2001 • 195 citations

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

1994 • 183 citations

p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

1997 • 169 citations

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death

1998 • 163 citations

Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity

2004 • 162 citations

Doxorubicin Induces Apoptosis and CD95 Gene Expression in Human Primary Endothelial Cells through a p53-dependent Mechanism

2002 • 156 citations

Pifithrin-α protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice

2004 • 156 citations

Pifithrin-α supresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis

2003 • 154 citations

Apoptosis and protein expression after focal cerebral ischemia in rat

1997 • 153 citations

The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin ?

2004 • 146 citations

Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

2003 • 144 citations

Regulation of cardiomyocyte apoptosis by redox‐sensitive transcription factors

2000 • 125 citations

p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation

2003 • 123 citations

Reciprocal Inhibition of p53 and Nuclear Factor-κB Transcriptional Activities Determines Cell Survival or Death in Neurons

2003 • 122 citations

Multiple signaling events in amyloid β-induced, oxidative stress-dependent neuronal apoptosis

2003 • 118 citations

NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope

2004 • 115 citations

Apoptosis in ischemic renal injury: Roles of GTP depletion and p53

2004 • 113 citations

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.

1996 • 113 citations

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons

1998 • 112 citations

p53 Inhibitor Pifithrin α Can Suppress Heat Shock and Glucocorticoid Signaling Pathways

2003 • 110 citations

Induction of tumour‐suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids

1998 • 106 citations

Pifithrin-α Inhibits p53 Signaling after Interaction of the Tumor Suppressor Protein with hsp90 and Its Nuclear Translocation

2004 • 106 citations

Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells

2004 • 105 citations

Inhibition of p53 protects liver tissue against endotoxin‐induced apoptotic and necrotic cell death

2003 • 105 citations

Novel p53 Inactivators with Neuroprotective Action: Syntheses and Pharmacological Evaluation of 2-Imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-Imino-2,3,4,5,6,7-hexahydrobenzoxazole Derivatives

2002 • 103 citations

p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner

2003 • 103 citations

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

1997 • 103 citations

Cellular Prion Protein Sensitizes Neurons to Apoptotic Stimuli through Mdm2-regulated and p53-dependent Caspase 3-like Activation

2003 • 98 citations

Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress

2004 • 94 citations

Bcl-2 Mediates Chemoresistance in Matched Pairs of Primary Eμ-myc Lymphomas in Vivo

2001 • 91 citations

Radiation-induced apoptosis in the adult central nervous system is p53-dependent

2000 • 91 citations

Inhibition of p53 function diminishes androgen receptor-mediated signaling in prostate cancer cell lines

2004 • 91 citations

Improving cancer therapy by non-genotoxic activation of p53

2003 • 91 citations

Activation of p53 and its target genes p21WAF1/Cip1 and PAG608/Wig-1 in ischemic preconditioning

1999 • 88 citations

Oxidative stress induces p53‐mediated apoptosis in glia: p53 transcription‐independent way to die

2003 • 87 citations

Involvement of p53 in specific anti‐neuroectodermal tumor activity of aloe‐emodin

2003 • 84 citations

Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients.

1998 • 81 citations

Cycloheximide phase-shifts, but does not prevent, de novo Krox-24 protein expression

1997 • 74 citations

Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors 2 2Abbreviations: CP, cyclophosphamide; PFT, pifithrin-α or p53 inhibitor; HT, hyperthermia; HS, heat shock; HO, hypoxia; and HIF-1, hypoxia inducible factor.

2001 • 74 citations

p53 is Present in Synapses Where it Mediates Mitochondrial Dysfunction and Synaptic Degeneration in Response to DNA Damage, and Oxidative and Excitotoxic Insults

2003 • 73 citations

Different Responses of Epidermal and Hair Follicular Cells to Radiation Correlate with Distinct Patterns of p53 and p21 Induction

1999 • 69 citations

p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent.

2001 • 65 citations

The challenge of p53 as prognostic and predictive factor in gliomas

2000 • 56 citations

p53 down‐regulation: a new molecular mechanism involved in ischaemic preconditioning

2003 • 55 citations

Acceleration of Cutaneous Wound Healing by Transient p53 Inhibition

2002 • 54 citations

Improvement of rat liver graft quality by pifithrin-?-mediated inhibition of hepatocyte necrapoptosis

2004 • 53 citations

Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor

1999 • 53 citations

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro.

2003 • 52 citations

The C-terminal Fragment of Presenilin 2 Triggers p53-mediated Staurosporine-induced Apoptosis, a Function Independent of the Presenilinase-derived N-terminal Counterpart

2003 • 51 citations

Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat

1999 • 51 citations

Induction of Tumor Suppressor p53 and DNA Fragmentation in Organotypic Hippocampal Cultures Following Excitotoxin Treatment

1997 • 50 citations

Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc

2004 • 50 citations

Could p53 be a target for therapeutic suppression?

1998 • 50 citations

The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia

1999 • 49 citations

Regulation of functional nuclear pore size in fibroblasts

2001 • 49 citations

Paradoxical role of apoptosis in tumor progression

2002 • 48 citations

The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.

1999 • 47 citations

Pifithrin-α, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro

2002 • 45 citations

Tumor Suppressing Gene Therapy

2003 • 45 citations

The Promise and Obstacle of p53 as a Cancer Therapeutic Agent

2002 • 45 citations

Growth Inhibition of Cervical Tumor Cells by Antisense Oligodeoxynucleotides Directed to the Human Papillomavirus Type 16 E6 Gene

1999 • 43 citations

Susceptibility to cytosine arabinoside (Ara-C)-induced cytotoxicity in human leukemia cell lines

2004 • 42 citations

Normal breast epithelial cells induce p53-dependent apoptosis and p53-independent cell cycle arrest of breast cancer cells

2002 • 42 citations

Gamma-Ray-Induced Cell Killing and Chromosome Abnormalities in the Bone Marrow of p53-Deficient Mice

1996 • 38 citations

p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells

2003 • 36 citations

Role of p53 in DNA strand break-induced apoptosis in organotypic slice culture from the mouse cerebellum

2000 • 34 citations

Apoptosis Inhibitor as a Suppressor of Tumor Progression: Expression of Bcl-2 Eliminates Selective Advantages for p53-Deficient Cells in the Tumor

2002 • 31 citations

Pifithrin‐α promotes p53‐mediated apoptosis in JB6 cells

2003 • 31 citations

Inhibition of p53, p21 and Bax by pifithrin-α does not affect UV induced apoptotic response in CS-B cells

2003 • 29 citations

p53 oncoprotein as a prognostic indicator in patients with breast cancer.

1998 • 26 citations

Influence of altered apoptosis in human lymphoblastoid cell lines on micronucleus frequency

2003 • 26 citations

Genetic alterations associated with bladder cancer.

1994 • 24 citations

DNA topoisomerase II poisons and inhibitors.

1997 • 24 citations

Apoptosis in bone marrow cells of mice with different p53 genotypes after gamma-rays irradiation in vitro.

1995 • 23 citations

DNA topoisomerase I poisons.

1999 • 16 citations

Regulation of Steroidogenesis by p53 in Macaque Granulosa Cells and H295R Human Adrenocortical Cells

2004 • 14 citations

ZFM1/SF1 mRNA in rat and gerbil brain after global ischaemia

1999 • 12 citations

Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium.

2002 • 8 citations