Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

Surfing the p53 network

2000 • 6,487 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

2003 • 1,266 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

2000 • 643 citations

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

2003 • 551 citations

Dissecting p53 tumor suppressor functions in vivo

2002 • 491 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System

1998 • 425 citations

Expression of bbc3 , a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

2001 • 402 citations

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

2001 • 331 citations

Microarray Analysis Uncovers the Induction of the Proapoptotic BH3-only Protein Bim in Multiple Models of Glucocorticoid-induced Apoptosis

2003 • 227 citations

Apoptosis Triggered by Myc-Induced Suppression of Bcl-X_L or Bcl-2 Is Bypassed during Lymphomagenesis

2001 • 210 citations

Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

2001 • 210 citations

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

2000 • 150 citations

Selective regulation ofBcl-X_Lby a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

1998 • 110 citations