Early Single Cell Bifurcation of Pro- and Antiapoptotic States during Oxidative Stress

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Biochemical Pathways of Caspase Activation During Apoptosis

1999 • 2,567 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

Oxidative stress and gene regulation

2000 • 1,298 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Regulation of p53 in response to DNA damage

1999 • 960 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Chaperoning signaling pathways: molecular chaperones as stress-sensing`heat shock' proteins

2002 • 655 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

Neuronal Cell Death

1998 • 593 citations

Oxy-radicals and cancer

1994 • 582 citations

Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes

1995 • 538 citations

Fundamental Aspects of Reactive Oxygen Species, or What's the Matter with Oxygen?

1999 • 530 citations

Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays

2002 • 522 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

2002 • 449 citations

ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53

2002 • 408 citations

Putting the stress on senescence

2001 • 407 citations

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

1999 • 384 citations

Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53

2001 • 352 citations

Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression

2002 • 336 citations

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

2001 • 316 citations

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

2002 • 313 citations

BH3-only Bcl-2 Family Members Are Coordinately Regulated by the JNK Pathway and Require Bax to Induce Apoptosis in Neurons

2001 • 309 citations

The Course of Etoposide-induced Apoptosis from Damage to DNA and p53 Activation to Mitochondrial Release of Cytochromec

2002 • 299 citations

Single-cell Fluorescence Resonance Energy Transfer Analysis Demonstrates That Caspase Activation during Apoptosis Is a Rapid Process

2002 • 297 citations

Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin

2000 • 280 citations

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM

1995 • 253 citations

FAK Is the Upstream Signal Protein of the Phosphatidylinositol 3-Kinase-Akt Survival Pathway in Hydrogen Peroxide-induced Apoptosis of a Human Glioblastoma Cell Line

1999 • 252 citations

Dopaminergic cell death induced by MPP⁺, oxidant and specific neurotoxicants shares the common molecular mechanism

2001 • 251 citations

p53

2002 • 249 citations

Nerve Growth Factor-induced Neuronal Differentiation Requires Generation of Rac1-regulated Reactive Oxygen Species

2000 • 248 citations

Gαi and Gαo are target proteins of reactive oxygen species

2000 • 244 citations

A Role for MAPK/ERK in Sympathetic Neuron Survival: Protection against a p53-Dependent, JNK-Independent Induction of Apoptosis by Cytosine Arabinoside

1999 • 243 citations

ERK-1/2 and p38 Kinase Oppositely Regulate Nitric Oxide-induced Apoptosis of Chondrocytes in Association with p53, Caspase-3, and Differentiation Status

2002 • 242 citations

Mechanisms of switching on p53: a role for covalent modification?

1999 • 236 citations

Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells

1999 • 221 citations

Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor Cytochrome c

1998 • 216 citations

The gene PC3^TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?

2001 • 207 citations

Neuroprotection and Neuronal Differentiation Studies Using Substantia Nigra Dopaminergic Cells Derived from Transgenic Mouse Embryos

1999 • 196 citations

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

1999 • 193 citations

Gonadotropin-releasing Hormone Receptor-coupled Gene Network Organization

2001 • 188 citations

p53-dependent cell death signaling in neurons.

2003 • 180 citations

Isolation and Characterization of a Novel Dual Specific Phosphatase, HVH2, Which Selectively Dephosphorylates the Mitogen-activated Protein Kinase

1995 • 179 citations

Regulation of mitogenesis by kinins in arterial smooth muscle cells

1997 • 170 citations

Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism

1993 • 163 citations

Prevention of PC12 Cell Death byN-Acetylcysteine Requires Activation of the Ras Pathway

1998 • 162 citations

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

2001 • 146 citations

Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway

2001 • 130 citations

Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway

1997 • 128 citations

Extracellular Signal-regulated Kinase Mediates Phosphorylation of Tropomyosin-1 to Promote Cytoskeleton Remodeling in Response to Oxidative Stress: Impact on Membrane Blebbing

2003 • 106 citations

Agonist-specific Transactivation of Phosphoinositide 3-Kinase Signaling Pathway Mediated by the Dopamine D2 Receptor

2003 • 94 citations

Activation of p53 by Oxidative Stress Involves Platelet-derived Growth Factor-β Receptor-mediated Ataxia Telangiectasia Mutated (ATM) Kinase Activation

2003 • 93 citations

Hydrogen Peroxide Signaling through Tumor Necrosis Factor Receptor 1 Leads to Selective Activation of c-Jun N-terminal Kinase

2003 • 81 citations

Tyrosine Phosphorylation Regulates H2O2Production in Lung Fibroblasts Stimulated by Transforming Growth Factor β1

1998 • 81 citations

Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines

2003 • 77 citations

Bcl-2 blocks cisplatin-induced apoptosis by suppression of ERK-mediated p53 accumulation in B104 cells

2001 • 54 citations

Monitoring G-Protein-Coupled Receptor Signaling with DNA Microarrays and Real-Time Polymerase Chain Reaction

2002 • 48 citations