Activation of p53 and its target genes p21WAF1/Cip1 and PAG608/Wig-1 in ischemic preconditioning

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

‘Ischemic tolerance’ phenomenon found in the brain

1990 • 1,098 citations

Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model

1984 • 741 citations

Experimental cerebral ischemia in Mongolian gerbils

1975 • 642 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

Temporal profile of the effects of pretreatment with brief cerebral ischemia on the neuronal damage following secondary ischemic insult in the gerbil: cumulative damage and protective effects

1991 • 303 citations

Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections: Androgen receptor, estrogen receptor, progesterone receptor, p53 protein, proliferating cell nuclear antigen, and Ki-67 antigen revealed by antigen retrieval techniques

1994 • 271 citations

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

1997 • 270 citations

Spreading Depression Induces Tolerance of Cortical Neurons to Ischemia in Rat Brain

1995 • 266 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

1996 • 248 citations

Evidence for p53-Mediated Modulation of Neuronal Viability

1996 • 247 citations

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1998 • 243 citations

Damage, Repair, and Mutagenesis in Nuclear Genes after Mouse Forebrain Ischemia–Reperfusion

1996 • 228 citations

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

1994 • 183 citations

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1997 • 171 citations

p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

1997 • 169 citations

Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance

1994 • 161 citations

Increased Hypoxic Tolerance by Chemical Inhibition of Oxidative Phosphorylation: “Chemical Preconditioning”

1997 • 161 citations

Repair Defect in p21 WAF1/CIP1 -/- human cancer cells.

1996 • 158 citations

Temporal profile of heat shock protein 70 synthesis in ischemic tolerance induced by preconditioning ischemia in rat hippocampus

1993 • 155 citations

The dual role model for p53 in maintaining genomic integrity

1999 • 150 citations

Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein

1988 • 115 citations

Anti-apoptotic activity of low levels of wild-type p53.

1996 • 109 citations

Changes in Protein Tyrosine Phosphorylation in the Rat Brain after Cerebral Ischemia in a Model of Ischemic Tolerance

1999 • 86 citations

Nuclear accumulation of p53 protein following kainic acid-induced seizures

1996 • 84 citations

Cycloheximide phase-shifts, but does not prevent, de novo Krox-24 protein expression

1997 • 74 citations

Early recovery of protein synthesis following ischemia in hippocampal neurons with induced tolerance in the gerbil

1993 • 71 citations

Wig-1, a new p53-induced gene encoding a zinc finger protein

1997 • 67 citations

Sequential activation of activator protein-1-related transcription factors and JNK protein kinases may contribute to apoptotic death induced by transient hypoxia in developing brain neurons

1998 • 65 citations

Tumor Suppressor p53 Induction and DNA Damage in Hippocampal Granule Cells after Adrenalectomy

1994 • 62 citations

Comparison of two microwave based antigen-retrieval solutions in unmasking epitopes in formalin-fixed tissue for immunostaining.

1995 • 57 citations

Granule cell apoptosis and protein expression in hippocampal dentate gyrus after forebrain ischemia in the rat

1997 • 51 citations

The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia

1999 • 49 citations

Changes in proliferating cell nuclear antigen, a protein involved in DNA repair, in vulnerable hippocampal neurons following global cerebral ischemia

1998 • 47 citations

Transcriptional Regulation of the PCNA Promoter by p53

1994 • 46 citations

Induction of Jun-like immunoreactivity in astrocytes in gerbil hippocampus with ischemic tolerance

1995 • 26 citations

Ischemic tolerance and extracellular amino acid concentrations in gerbil hippocampus measured by intracerebral microdialysis

1994 • 20 citations