Paradoxical role of apoptosis in tumor progression

Proliferation, cell cycle and apoptosis in cancer

2001 • 3,236 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Apoptosis

2002 • 2,190 citations

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

2002 • 1,009 citations

Dissecting p53 tumor suppressor functions in vivo

2002 • 491 citations

Down-regulation of bcl-2 by p53 in breast cancer cells.

1994 • 479 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Bcl-2 protein expression and long-term survival in breast cancer.

1994 • 404 citations

Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.

1996 • 360 citations

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

1997 • 343 citations

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.

1996 • 325 citations

Apoptosis regulators and their role in tumorigenesis

2001 • 239 citations

The contribution of molecular markers to the prediction of response in the treatment of breast cancer: A review of the literature on HER-2, p53 and BCL-2

2000 • 175 citations

bcl-2 and apoptosis in lymph node positive breast carcinoma

1998 • 126 citations

How apoptosis is regulated, and what goes wrong in cancer

2001 • 95 citations

Apoptotic index correlates to bcl-2 and p53 protein expression, histological grade and prognosis in invasive breast cancers.

1998 • 87 citations

Antagonism between estradiol and progestin on Bcl-2 expression in breast-cancer cells

1996 • 87 citations

Bax accelerates tumorigenesis in p53-deficient mice.

2001 • 84 citations

Apoptosis during breast carcinoma progression.

1999 • 83 citations

Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity

1998 • 82 citations

Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model

1999 • 54 citations

Paradoxical inhibition of c-myc-induced carcinogenesis by Bcl-2 in transgenic mice.

1999 • 54 citations

Clinical significance of bcl-2 gene expression in human breast cancer tissues

1997 • 53 citations

Bcl-2 protein expression in breast cancer in relation to established prognostic factors and other clinicopathological variables

1995 • 52 citations

BILHARZIAL RELATED, ORGAN CONFINED, MUSCLE INVASIVE BLADDER CANCER: PROGNOSTIC VALUE OF APOPTOSIS MARKERS, PROLIFERATION MARKERS, p53, E-CADHERIN, EPIDERMAL GROWTH FACTOR RECEPTOR AND c-erbB-2

2001 • 51 citations

Expression of bcl-2 in invasive and in situ carcinoma of the uterine cervix

1998 • 50 citations

Spontaneous Apoptosis and the Expression of p53 and Bcl-2 Family Proteins in Locally Advanced Head and Neck Cancer

1999 • 46 citations

Bcl-2 delays and alters hepatic carcinogenesis induced by transforming growth factor alpha.

2001 • 44 citations

Expression of Bax and Apoptosis-Related Proteins in Human Esophageal Squamous Cell Carcinoma Including Dysplasia

2001 • 42 citations

p53 mutation in breast cancer. Correlation with cell kinetics and cell of origin

2002 • 42 citations

Bcl-2 expression as a prognostic factor of survival of gastric carcinoma.

1998 • 40 citations

Effect of Bcl‐2 overexpression in human prostate cancer cells in vitro and in vivo

1999 • 39 citations

Immunohistochemical expression of bcl-2 protein in squamous cell carcinoma and basaloid carcinoma of the esophagus

1997 • 38 citations

Cell transforming genes and tumor progression: In vivo unified secondary phenotypic cell changes

1998 • 35 citations

Different expression patterns of Bcl-2 family genes in breast cancer by estrogen receptor status with special reference to pro-apoptotic Bak gene

2000 • 35 citations

Bcl2, p53 and clinical outcome in a series of 138 operable breast cancer patients.

2000 • 35 citations

Apoptosis Inhibitor as a Suppressor of Tumor Progression: Expression of Bcl-2 Eliminates Selective Advantages for p53-Deficient Cells in the Tumor

2002 • 31 citations

Bcl‐X expression in esophageal squamous cell carcinoma: Association with tumor progression and prognosis

2001 • 30 citations

Accelerated apoptosis and low Bcl-2 expression associated with neuroendocrine differentiation predict shortened survival in operated large cell carcinoma of the lung

1999 • 25 citations

Correlation of tumor markers p53, bcl‐2 and cathepsin‐D with clinicopathologic features and disease‐free survival in laryngeal squamous cell carcinoma

2000 • 24 citations

Bcl-2 is closely correlated with favorable prognostic factors and inversely associated with p53 protein accumulation in endometrial carcinomas: immunohistochemical and polymerase chain reaction/loss of heterozygosity findings

1997 • 21 citations

Expression of bcl-2 protein in gastric carcinoma and its significance

1998 • 21 citations

Cytometric analysis of Fas and Bcl-2 expression in normal prostatic epithelium and prostate cancer

2000 • 12 citations

Bcl-2 expression in F-MuLV-induced erythroleukemias: a role for the anti-apoptotic action of Bcl-2 during tumor progression

2001 • 10 citations

Apoptosis in prostatic adenocarcinomas; a study of relationship to Ki-67 and Bcl-2 protein expression.

1998 • 9 citations

[Bcl-2, p53, Ki-67 and apoptotic index in cancerous and precancerous lesions of the oral mucosa].

1999 • 3 citations