Doxorubicin Induces Apoptosis in Normal and Tumor Cells via Distinctly Different Mechanisms

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Caspases: killer proteases

1997 • 2,440 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Doxorubicin-Induced Cardiomyopathy

1998 • 1,774 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

The p53 Network

1998 • 731 citations

Redox regulation of transcriptional activators

1996 • 690 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

Doxorubicin-induced Apoptosis in Endothelial Cells and Cardiomyocytes Is Ameliorated by Nitrone Spin Traps and Ebselen

2000 • 368 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1980 • 317 citations

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide

2001 • 315 citations

Early and delayed clinical cardiotoxicity of doxorubicin

1985 • 300 citations

Regulation of Cardiomyocyte Apoptotic Signaling by Insulin-like Growth Factor I

1998 • 283 citations

Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide

2002 • 270 citations

Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.

1996 • 218 citations

Fas-Mediated Apoptosis in Adriamycin-Induced Cardiomyopathy in Rats

2000 • 217 citations

Daunorubicin-Induced Apoptosis in Rat Cardiac Myocytes Is Inhibited by Dexrazoxane

1999 • 204 citations

Signaling pathways activated by daunorubicin

2001 • 182 citations

Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance.

1989 • 159 citations

Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis

2000 • 158 citations

Doxorubicin Induces Apoptosis and CD95 Gene Expression in Human Primary Endothelial Cells through a p53-dependent Mechanism

2002 • 156 citations

Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells

1994 • 151 citations

Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells.

2001 • 149 citations

Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokines.

1996 • 137 citations

Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation

2000 • 136 citations

ATF3 Inhibits Doxorubicin-induced Apoptosis in Cardiac Myocytes: A Novel Cardioprotective Role of ATF3

2002 • 125 citations

GPx-1 Gene Delivery Modulates NFκB Activation Following Diverse Environmental Injuries Through a Specific Subunit of the IKK Complex

2001 • 90 citations

Benzo[a]pyrene Activates the Human p53 Gene through Induction of Nuclear Factor κB Activity

1999 • 89 citations

Methionine depletion enhances the antitumoral efficacy of cytotoxic agents in drug-resistant human tumor xenografts.

2000 • 80 citations

Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors 2 2Abbreviations: CP, cyclophosphamide; PFT, pifithrin-α or p53 inhibitor; HT, hyperthermia; HS, heat shock; HO, hypoxia; and HIF-1, hypoxia inducible factor.

2001 • 74 citations

Characterization of a silencer regulatory element in the human interferon-gamma promoter.

1994 • 62 citations

Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1

2002 • 60 citations

Induction of Apoptosis by Chemotherapeutic Drugs without Generation of Reactive Oxygen Species

2002 • 59 citations

Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine.

2002 • 54 citations

Unexpected Anthracycline-Mediated Alterations in Iron-Regulatory Protein-RNA-Binding Activity: The Iron and Copper Complexes of Anthracyclines Decrease RNA-Binding Activity

2002 • 54 citations

The C-terminal Fragment of Presenilin 2 Triggers p53-mediated Staurosporine-induced Apoptosis, a Function Independent of the Presenilinase-derived N-terminal Counterpart

2003 • 51 citations

Reactivity of Mono-Meso-Substituted Iron(II) Octaethylporphyrin Complexes with Hydrogen Peroxide in the Absence of Dioxygen. Evidence for Nucleophilic Attack on the Heme

2001 • 42 citations

Overexpression of manganese superoxide dismutase promotes survival in cell lines after doxorubicin treatment

2003 • 37 citations

Phorbol Esters Attenuate the Expression of p53 in Cells Treated with Doxorubicin and Protect ts-p53/K562 from Apoptosis

1995 • 35 citations

Thiol redox modulation of doxorubicin mediated cytotoxicity in cultured AIDS-related Kaposi's sarcoma cells

1999 • 23 citations

Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes

2000 • 19 citations

NF-κB prevents cells from undergoing Cr(VI)-induced apoptosis

2003 • 12 citations