Pifithrin-α Inhibits p53 Signaling after Interaction of the Tumor Suppressor Protein with hsp90 and Its Nuclear Translocation

p53 Mutations in Human Cancers

1991 • 8,133 citations

Surfing the p53 network

2000 • 6,487 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery

2003 • 1,470 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

2000 • 352 citations

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide

2001 • 315 citations

Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement

2004 • 280 citations

p53

2002 • 249 citations

Evidence That the Peptidylprolyl Isomerase Domain of the hsp90-binding Immunophilin FKBP52 Is Involved in Both Dynein Interaction and Glucocorticoid Receptor Movement to the Nucleus

2001 • 240 citations

Dial 9-1-1 for p53: Mechanisms of p53 Activation by Cellular Stress

2000 • 223 citations

New approaches to understanding p53 gene tumor mutation spectra

1999 • 199 citations

Inhibition of MDM2 by hsp90 Contributes to Mutant p53 Stabilization

2001 • 180 citations

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

1991 • 180 citations

Heat Shock Protein 90-Dependent (Geldanamycin-Inhibited) Movement of the Glucocorticoid Receptor through the Cytoplasm to the Nucleus Requires Intact Cytoskeleton

1998 • 173 citations

Stepwise Assembly of a Glucocorticoid Receptor·hsp90 Heterocomplex Resolves Two Sequential ATP-dependent Events Involving First hsp70 and Then hsp90 in Opening of the Steroid Binding Pocket

2000 • 168 citations

Pifithrin-α supresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis

2003 • 154 citations

Hsp90-binding Immunophilins Link p53 to Dynein During p53 Transport to the Nucleus

2004 • 150 citations

Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

2003 • 144 citations

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

1991 • 142 citations

Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin.

1993 • 137 citations

An FK506-sensitive Transporter Selectively Decreases Intracellular Levels and Potency of Steroid Hormones

1996 • 125 citations

Reciprocal Inhibition of p53 and Nuclear Factor-κB Transcriptional Activities Determines Cell Survival or Death in Neurons

2003 • 122 citations

Binding of hsp90-Associated Immunophilins to Cytoplasmic Dynein: Direct Binding and in Vivo Evidence that the Peptidylprolyl Isomerase Domain Is a Dynein Interaction Domain

2002 • 119 citations

p53 Inhibitor Pifithrin α Can Suppress Heat Shock and Glucocorticoid Signaling Pathways

2003 • 110 citations

Inhibition of p53 protects liver tissue against endotoxin‐induced apoptotic and necrotic cell death

2003 • 105 citations

Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors 2 2Abbreviations: CP, cyclophosphamide; PFT, pifithrin-α or p53 inhibitor; HT, hyperthermia; HS, heat shock; HO, hypoxia; and HIF-1, hypoxia inducible factor.

2001 • 74 citations

The Tumor Suppressor p53 Can Both Stimulate and Inhibit Ultraviolet Light–induced Apoptosis

2000 • 54 citations

Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells.

1996 • 48 citations