p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Establishment and characterization of a human prostatic carcinoma cell line (PC-3).

1979 • 1,595 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

The biochemistry of programmed cell death

1995 • 997 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis?

1996 • 613 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Nuclear changes in apoptosis

1995 • 538 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Free Radicals and Brain Damage

1993 • 527 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

1995 • 517 citations

Interfering with Apoptosis: Ca ²⁺ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

1996 • 481 citations

Cytostatic Gene Therapy for Vascular Proliferative Disorders with a Constitutively Active form of the Retinoblastoma Gene Product

1995 • 455 citations

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

1991 • 440 citations

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

1988 • 384 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.

1995 • 363 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus.

1994 • 285 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM

1995 • 253 citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

1996 • 244 citations

The role of free radicals and p53 in neuron apoptosis in vivo

1995 • 239 citations

Development and Characterization of Recombinant Adenoviruses Encoding Human p53 for Gene Therapy of Cancer

1994 • 235 citations

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.

1994 • 225 citations

gp120-Induced Neurotoxicity in Hippocampal Pyramidal Neuron Cultures: Protective Action of TGF-β1

1996 • 204 citations

p53 Plays a Regulatory Role in Differentiation and Apoptosis of Central Nervous System-Associated Cells

1996 • 199 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

1994 • 183 citations

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1996 • 163 citations

Hypoxia Induces Accumulation of p53 Protein, but Activation of a G₁-Phase Checkpoint by Low-Oxygen Conditions Is Independent of p53 Status

1994 • 144 citations

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB.

1995 • 136 citations

Developmental changes in presynaptic calcium channels coupled to glutamate release in cultured rat hippocampal neurons

1995 • 128 citations

p53 Expression in brain after middle cerebral artery occlusion in the rat

1992 • 120 citations

Regulation of excitatory transmission at hippocampal synapses by calbindin D28k.

1995 • 119 citations

Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons

1995 • 118 citations

Life and death by P53

1995 • 111 citations

p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons

1996 • 107 citations

Isoform-Specific Effects of Transforming Growth Factors-? on Degeneration of Primary Neuronal Cultures Induced by Cytotoxic Hypoxia or Glutamate

1993 • 95 citations

Direct involvement of p53 in programmed cell death of oligodendrocytes.

1995 • 89 citations

Bcl-2 Blocks p53-Dependent Apoptosis

1994 • 87 citations

Programmed neuronal death in insect development

1992 • 82 citations

Developmental and abnormal cell death in C. Elegans

1992 • 80 citations

Book Reviews Science and Dissent in Post-Mao China, reviewed by M. Goldman * Comparative Vertebrate Neuroanatomy, E. G. Jones * Particle Physics, P. Forman * Vignette * Browsings

1996 • 70 citations

The role of the p53 protein in the apoptotic response

1994 • 63 citations

Tumor Suppressor p53 Induction and DNA Damage in Hippocampal Granule Cells after Adrenalectomy

1994 • 62 citations

Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor.

1995 • 58 citations

Cell death and the creation of regional differences in neuronal numbers

1992 • 52 citations

Glutamate-stimulated protein phosphorylation in cultured hippocampal pyramidal neurons

1991 • 48 citations

Presynaptic inhibition at excitatory hippocampal synapses: development and role of presynaptic Ca2+ channels

1996 • 42 citations

p53 protein in sympathetic neurons: Cytoplasmic localization and no apparent function in apoptosis

1996 • 40 citations

Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins

1994 • 37 citations

Consequences of p53 Gene Expression by Adenovirus Vector on Cell Cycle Arrest and Apoptosis in Human Aortic Vascular Smooth Muscle Cells

1995 • 37 citations

Irradiation injury to the developing nervous system: mechanisms of neuronal injury.

1994 • 34 citations

Retinoblastoma gene in mouse neural development

1996 • 29 citations

Comparative alterations in p53 expression and apoptosis in the irradiated rat small and large intestine

1996 • 28 citations

Functions of pRb and p53: what's the connection?

1995 • 20 citations

‘More effectiveness needed’ in Brussels' handling of research

1998 • 1 citations