Transcription factor interactions: basics on zippers

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

1989 • 488 citations

Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun

1989 • 469 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

Sequence-Specific DNA Binding by a Short Peptide Dimer

1990 • 318 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB.

1990 • 290 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

1987 • 279 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.

1990 • 245 citations

Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP

1989 • 237 citations

Altered protein conformation on DNA binding by Fos and Jun

1990 • 193 citations

Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes.

1989 • 191 citations

Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins.

1989 • 164 citations

Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy

1990 • 139 citations

The basic region of Fos mediates specific DNA binding.

1989 • 132 citations

Evidence of Changes in Protease Sensitivity and Subunit Exchange Rate on DNA Binding by C/EBP

1990 • 127 citations

Molecular characterization of the GCN4-DNA complex.

1990 • 101 citations

Structural Motif of the GCN4 DNA Binding Domain Characterized by Affinity Cleaving

1990 • 91 citations

Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping "leucine zippers"

1989 • 90 citations

Thermal unfolding studies of a leucine zipper domain and its specific DNA complex: implications for scissor's grip recognition

1990 • 73 citations

Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region.

1990 • 67 citations

Trans-dominant negative mutants of Fos and Jun.

1990 • 66 citations

Domain Swapping Reveals the Modular Nature of Fos, Jun, and CREB Proteins

1990 • 46 citations

Alkylation interference identifies essential DNA contacts for sequence-specific binding of the eukaryotic transcription factor C/EBP.

1990 • 35 citations

Jun DNA-binding is modulated by mutations between the leucines or by direct interaction of fos with the TGACTCA sequence.

1989 • 33 citations

Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: Both Fos and Jun contact DNA directly

1990 • 24 citations

Domain swapping reveals the modular nature of Fos, Jun, and CREB proteins.

1990 • 20 citations