Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation

1989 • 494 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte—macrophage colony stimulating factor

1984 • 451 citations

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

1993 • 389 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6

1988 • 292 citations

Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells.

1984 • 258 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

1985 • 178 citations

Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.

1990 • 163 citations

CD4+ T cell-mediated killing of MHC class II-positive antigen-presenting cells. I. Characterization of target cell recognition by in vivo or in vitro activated CD4+ killer T cells.

1990 • 86 citations

Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro.

1988 • 75 citations

Cloning and nucleotide sequence of the murine interleukin‐3 gene

1985 • 62 citations

Reversible abrogation of IL-3 dependence by an inducible H-ras oncogene.

1989 • 48 citations

Spontaneous, in vitro, Malignant Transformation of a Basophil/Mast Cell Line

1983 • 39 citations

A v-H-ras-Dependent Hemopoietic Tumor Model Involving Progression from a Clonal Stage of Transformation Competence to Autocrine Interleukin 3 Production

1989 • 37 citations

Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene.

1993 • 31 citations

A v-H-ras-dependent hemopoietic tumor model involving progression from a clonal stage of transformation competence to autocrine interleukin 3 production.

1989 • 24 citations

Mast cells sensitive to v-H-ras transformation are hyperinducible for interleukin 3 expression and have lost tumor-suppressor activity.

1992 • 20 citations

Differential Inhibition by Cyclosporin A Reveals two Pathways for Activation of Lymphokine Synthesis in T Cells

1989 • 18 citations

Tumor suppression involves down-regulation of interleukin 3 expression in hybrids between autocrine mastocytoma and interleukin 3-dependent parental mast cells.

1989 • 17 citations