The ups and downs of T cell costimulation

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.

1993 • 116 citations

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1994 • 82 citations

Antigen presentation by resting B cells. Effectiveness at inducing T cell proliferation is determined by costimulatory signals, not T cell receptor occupancy.

1990 • 66 citations

Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction.

1994 • 32 citations