Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology

Protein folding in the cell

1992 • 4,138 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

1992 • 811 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: One in the presence and one in the absence of CsA

1991 • 399 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

1990 • 353 citations

Molecular cloning and overexpression of the human FK506-binding protein FKBP

1990 • 316 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.

1983 • 285 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.

1992 • 276 citations

Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides

1992 • 259 citations

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

1992 • 254 citations

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

1991 • 248 citations

T-Cell Differentiation is Influenced by Thymic Microenvironments

1991 • 239 citations

Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease.

1989 • 197 citations

INDUCTION OF GRAFT-VERSUS-HOST DISEASE AFTER AUTOLOGOUS BONE MARROW TRANSPLANTATION

1989 • 196 citations

Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment

1991 • 190 citations

Acute Graft-vs-Host Disease

1987 • 170 citations

Natural Products as Probes of Cellular Function: Studies of Immunophilins

1992 • 147 citations

Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin.

1990 • 145 citations

Inhibition of T and B lymphocyte proliferation by rapamycin.

1991 • 144 citations

Rapamycin and FK506 binding proteins (immunophilins)

1991 • 136 citations

Growth of epithelial cells in the thymic medulla is under the control of mature T cells.

1992 • 128 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin.

1990 • 120 citations

FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human Fc epsilon RI+ cells.

1991 • 118 citations

Thymus and autoimmunity. Transplantation of the thymus from cyclosporin A-treated mice causes organ-specific autoimmune disease in athymic nude mice.

1988 • 111 citations

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

1989 • 110 citations

Rapamycin: FK506's fraternal twin or distant cousin?

1991 • 107 citations

Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

1992 • 103 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas

1992 • 101 citations

The effect of the immunosuppressant FK‐506 on alternate pathways of T cell activation

1991 • 82 citations

Cellular signaling in thymocyte apoptosis.

1992 • 75 citations

Serine/threonine phosphatases in the nervous system

1991 • 64 citations

EVIDENCE THAT THE IMMUNOSUPPRESSIVE EFFECTS OF FK506 AND CYCLOSPORINE ARE IDENTICAL

1990 • 63 citations

Graft-vs.-Host Disease: Immunology, Pathophysiology, and Treatment

1991 • 62 citations

Biochemical characterization of the inhibitory effect of CsA on cytolytic T lymphocyte effector functions.

1989 • 59 citations

The requirements for triggering of lysis by cytolytic T lymphocyte clones. II. Cyclosporin A inhibits TCR-mediated exocytosis by only selectively inhibits TCR-mediated lytic activity by cloned CTL.

1989 • 58 citations

Cyclosporin A and the thymus. Immunopathology.

1987 • 57 citations

Disruption of CD8‐dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1992 • 57 citations

Immunosuppression with cyclosporin A alters the thymic microenvironment.

1989 • 56 citations

Development of αβ T cells

1993 • 56 citations

Effect of cyclosporin A on lymphopoiesis. II. Developmental defects of immature and mature thymocytes in fetal thymus organ cultures treated with cyclosporin A.

1989 • 50 citations

A role for calcineurin in degranulation of murine cytotoxic T lymphocytes.

1993 • 47 citations

Cyclosporin A and FK506 mediate differential effects on T cell activation in vivo.

1992 • 47 citations

INDUCTION OF A SYNGENEIC GRAFT-VERSUS-HOST DISEASE-LIKE SYNDROME IN DBA/2 MICE

1989 • 45 citations

Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D-diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity.

1993 • 42 citations

Mechanism of action of cyclosporine A in vivo. II. T cell priming in vivo to alloantigen can be mediated by an IL-2-independent cyclosporine A-resistant pathway.

1990 • 42 citations

Cyclosporine and the thymus: Influence of irradiation and age on thymic immunopathology and recovery

1987 • 35 citations

The influence of FK-506 on the thymus: an immunophenotypic and structural analysis.

1990 • 31 citations

Acute graft-vs-host disease. Development following autologous and syngeneic bone marrow transplantation

1987 • 27 citations

THE THYMUS AND PROLONGED ADMINISTRATION OF CYCLOSPORINE

1990 • 27 citations

Effect of cyclosporin A on T cell immunity I. Dose‐dependent suppression of different murine T helper cell pathways

1989 • 26 citations

Loss of medullary dendritic cells in the thymus after cyclosporine and irradiation

1991 • 24 citations

Relationship of cyclosporine A-mediated inhibition of clonal deletion and development of syngeneic graft-versus-host disease.

1991 • 23 citations

THE EFFECTS OF IMMUNOSUPPRESSIVE AGENTS ON IN VITRO PRODUCTION OF HUMAN IMMUNOGLOBULINS

1991 • 23 citations

Effect of cyclosporin A on lymphopoiesis. III. Augmentation of the generation of natural killer cells in bone marrow transplanted mice treated with cyclosporin A.

1991 • 23 citations

The induction of pseudo-graft-versus-host disease following syngeneic bone marrow transplantation using FK 506.

1991 • 22 citations

Syngeneic Graft-vs-Host Disease

1987 • 21 citations

Self-reactive T cells are present in the peripheral lymphoid tissues of cyclosporin A-treated mice

1992 • 20 citations

Cyclosporin A and anti-Ia antibody cause a maturation defect of CD4+8- cells in organ-cultured fetal thymus.

1989 • 18 citations

Effect of cyclosporin A on T cell immunity II. Defective thymic education of CD4 T helper cell function in cyclosporin A‐treated mice

1989 • 17 citations

Effects of cyclosporine A on thymocyte differentiation in fetal thymus organ culture

1989 • 17 citations

An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination.

1990 • 16 citations

Tyrosine kinase triggering in thymocytes undergoing positive selection

1992 • 15 citations

EVIDENCE THAT CYCLOSPORINE TREATMENT CAUSES THE APPEARANCE IN RAT LYMPH NODE OF T CELLS HAVING THE ANTIGENIC PHENOTYPES OF CORTICAL THYMOCYTESNODE

1991 • 14 citations

Activation of idiotype-specific CD4+ T-cell line: cellular processing of exogenous self-immunoglobulin.

1990 • 14 citations

Effects of cyclosporin A on T-cell development in organ-cultured foetal thymus.

1990 • 13 citations

T-cell maturation and clonal deletion in cyclosporine-induced autoimmunity

1991 • 12 citations

Effect of FK 506 on CD4+ and CD8+ T-cell function in vivo.

1991 • 6 citations

Immunosuppressive effects of FK 506 on rat lymphoid organs.

1991 • 4 citations