Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

1980 • 1,997 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

1978 • 1,459 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

1990 • 924 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

1984 • 785 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Retinoic acid and thyroid hormone induce gene expression through a common responsive element

1988 • 586 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

1989 • 434 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

Octamania: The POU factors in murine development

1991 • 373 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

Octamer binding proteins confer transcriptional activity in early mouse embryogenesis.

1989 • 338 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors

1992 • 272 citations

Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements.

1992 • 246 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

Regulation of transcription and cell identity by POU domain proteins

1991 • 233 citations

Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors

1991 • 224 citations

The NFAT-1 DNA Binding Complex in Activated T Cells Contains Fra-1 and JunB

1993 • 215 citations

HOX gene activation by retinoic acid

1991 • 211 citations

Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.

1991 • 195 citations

A nexus between Oct-4 and E1 A: Implications for gene regulation in embryonic stem cells

1991 • 188 citations

Trans-repression of the mouse c-fos promoter: A novel mechanism of fos-mediated trans-regulation

1989 • 187 citations

The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.

1991 • 181 citations

Analysis of the AP-1 sites in the IL-2 promoter.

1992 • 179 citations

Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper

1991 • 177 citations

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.

1986 • 171 citations

Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins

1990 • 163 citations

A novel mechanism of action for v-ErbA: Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors

1991 • 154 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter.

1990 • 137 citations

Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.

1992 • 129 citations

Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes.

1993 • 129 citations

Retinoic acid receptor gamma: specific immunodetection and phosphorylation.

1991 • 121 citations

Functional Interference between the Ubiquitous and Constitutive Octamer Transcription Factor 1 (OTF-1) and the Glucocorticoid Receptor by Direct Protein-Protein Interaction Involving the Homeo Subdomain of OTF-1

1992 • 97 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.

1990 • 91 citations

Structure-function analysis of fos protein: A single amino acid change activates the immortalizing potential of v-fos

1987 • 81 citations

Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5'-flanking sequences.

1990 • 77 citations

Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line.

1990 • 74 citations

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.

1989 • 70 citations

A negative retinoic acid response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains.

1992 • 67 citations

Promoter Region of Interleukin-2 Gene Undergoes Chromatin Structure Changes and Confers Inducibility on Chloramphenicol Acetyltransferase Gene During Activation of T Cells

1986 • 67 citations

cis-Acting Sequences Required for Inducible Interleukin-2 Enhancer Function Bind a Novel Ets-Related Protein, Elf-1

1992 • 66 citations

Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif.

1991 • 63 citations

Oct2 Transactivation from a Remote Enhancer Position Requires a B-Cell-Restricted Activity

1992 • 63 citations

Neuromodulatory loop mediated by nerve growth factor and interleukin 6 in thymic stromal cell cultures.

1992 • 59 citations

Induction of the POU Domain Transcription Factor Oct-2 during T-Cell Activation by Cognate Antigen

1992 • 57 citations

Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription.

1993 • 56 citations

Transcriptional control of c-junby retinoic acid

1991 • 54 citations

Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1.

1992 • 51 citations

Distinct factors bind the AP-1 consensus sites in gibbon ape leukemia virus and simian virus 40 enhancers

1989 • 50 citations

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

1990 • 43 citations

Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen.

1992 • 38 citations

Transmission Of Signals From The T Lymphocyte Antigen Receptor To The Genes Responsible For Cell Proliferation And Immune Function: The Missing Link

1990 • 34 citations

Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity.

1992 • 32 citations

Octamania: The POU factors in murine development

1991 • 32 citations

The Promoter of the Human Interleukin-2 Gene Contains Two Octamer-Binding Sites and Is Partially Activated by the Expression of Oct-2

1990 • 31 citations

Molecular Basis for Developmental Changes in Interleukin-2 Gene Inducibility

1993 • 30 citations

Modulation of fibronectin and thymic stromal cell-dependent thymocyte maturation by retinoic acid.

1994 • 28 citations

Retinoic Acid Repression of Cell-Specific Helix-Loop-Helix-Octamer Activation of the Calcitonin/Calcitonin Gene-Related Peptide Enhancer

1993 • 26 citations

HOX gene activation by retinoic acid

1991 • 20 citations

An early response of an AP1-junD complex during T-cell activation.

1993 • 19 citations

Retinoic Acid-Induced Down-Regulation of the Interleukin-2 Promoter via cis-Regulatory Sequences Containing an Octamer Motif

1991 • 14 citations

DNA octamer element can confer E1A trans-activation, and adenovirus infection results in a stimulation of the DNA-binding activity of OTF-1/NFIII factor.

1990 • 14 citations