Positive and negative regulation of IL-2 gene expression: Role of multiple regulatory sites

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

T‐Cell Growth Factor

1980 • 917 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

Thymoma production of T cell growth factor (Interleukin 2).

1980 • 487 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1990 • 353 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro.

1988 • 309 citations

Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

1979 • 301 citations

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

1986 • 288 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

Interleukin-2 Induction of T-Cell G ₁ Progression and c- myb Expression

1986 • 248 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP ⁴⁰

1991 • 144 citations

A model system for peptide hormone action in differentiation: Interleukin 2 induces a B lymphoma to transcribe the J chain gene

1986 • 104 citations

The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.

1990 • 91 citations

The weak, fine-tuned binding of ubiquitous transcription factors to the II-2 enhancer contributes to its T cell-restricted activity

1992 • 62 citations

T-cell-specific expression of interleukin 2: evidence for a negative regulatory site.

1988 • 57 citations

Two regions within the human IL-2 gene promoter are important for inducible IL-2 expression.

1988 • 56 citations

One base pair change abolishes the T cell-restricted activity of a kB-like proto-enhancer element from the interleukin 2 promoter

1991 • 50 citations

Regulation of the Interleukin-2 Gene

2015 • 47 citations

Regulation of the Interleukin-2 Gene (Part 1 of 2)

1992 • 23 citations

Cyclosporin A and FK-506 both affect DNA binding of regulatory nuclear proteins to the human interleukin-2 promoter.

1991 • 16 citations