Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues

1987 • 1,107 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Synthetic oligonucleotide probes deduced from amino acid sequence data

1985 • 759 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

[20] Isolation of RNA using guanidinium salts

1987 • 614 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus.

1991 • 464 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.

1987 • 416 citations

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

1984 • 404 citations

DNA topoisomerase I is involved in both repression and activation of transcription

1993 • 380 citations

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1990 • 353 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

1986 • 288 citations

Isolation and Characterization of the Human Chromosomal Gene for Polypeptide Chain Elongation Factor-1α

1989 • 277 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

1992 • 242 citations

The NFAT-1 DNA Binding Complex in Activated T Cells Contains Fra-1 and JunB

1993 • 215 citations

Repression of c-fos transcription is mediated through p67SRF bound to the SRE.

1989 • 182 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer.

1990 • 171 citations

Identification of a Conserved Motif That Is Necessary for Binding of the Vaccinia Virus E3L Gene Products to Double-Stranded RNA

1993 • 157 citations

Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter.

1994 • 139 citations

The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter.

1990 • 137 citations

Relatedness of an RNA-Binding Motif in Human Immunodeficiency Virus Type 1 TAR RNA-Binding Protein TRBP to Human P1/dsI Kinase and Drosophila Staufen

1993 • 126 citations

Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

1991 • 108 citations

Transcriptional control—Lessons from an E. coli promoter data base

1991 • 95 citations

Differential regulation of colony-stimulating factors and interleukin 2 production by cyclosporin A.

1987 • 81 citations

Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes

1993 • 71 citations

T-cell-specific expression of interleukin 2: evidence for a negative regulatory site.

1988 • 57 citations

Two regions within the human IL-2 gene promoter are important for inducible IL-2 expression.

1988 • 56 citations

Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene.

1988 • 53 citations

The Immunosuppressant FK-506 Specifically Inhibits Mitogen- Induced Activation of the Interleukin-2 Promoter and the Isolated Enhancer Elements NFIL-2A and NF-AT1

1991 • 41 citations

BLAZE™: An implementation of the Smith-Waterman sequence comparison algorithm on a massively parallel computer

1993 • 40 citations

Identification of multiplecis-elements andtrans-acting factors involved in the induced expresson of human IL-2 gene

1989 • 39 citations

Silencing and trans-activation of the mouse IL-2 gene in Xenopus oocytes by proteins from resting and mitogen-induced primary T-lymphocytes.

1991 • 28 citations

Characterization of a protein that regulates the DNA-binding activity of NF-AT, the nuclear factor of activated T cells.

1991 • 17 citations