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Inflammation and cancer

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Cancer-related inflammation

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Exploring the full spectrum of macrophage activation

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Inflammation and cancer: back to Virchow?

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Macrophage Diversity Enhances Tumor Progression and Metastasis

2010 • 4,601 citations

The Nuclear Factor NF- B Pathway in Inflammation

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

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Calreticulin exposure dictates the immunogenicity of cancer cell death

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Paradoxical roles of the immune system during cancer development

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Regulation of Adaptive Immunity by the Innate Immune System

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Evolving functions of endothelial cells in inflammation

2007 • 1,714 citations

Tumour necrosis factor and cancer

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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

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Tumor-Associated Lymphocytes As an Independent Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer

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A blast from the past: clearance of apoptotic cells regulates immune responses

2002 • 1,558 citations

Immunological aspects of cancer chemotherapy

2007 • 1,535 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

2009 • 1,480 citations

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

2010 • 1,410 citations

Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated

2004 • 1,253 citations

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

2005 • 1,246 citations

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

2009 • 1,232 citations

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

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Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

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New insights into the regulation of T cells by γc family cytokines

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Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Systemic effects of local radiotherapy

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Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

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The Many Roles of FAS Receptor Signaling in the Immune System

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Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

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Cell death modalities: classification and pathophysiological implications

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Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

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Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

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Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

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Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

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Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity

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Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

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External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

Matrix Metalloproteinase-9 Is Required for Tumor Vasculogenesis but Not for Angiogenesis: Role of Bone Marrow-Derived Myelomonocytic Cells

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New vistas on macrophage differentiation and activation

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Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

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Natural Killer Cell Education and Tolerance

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Clinical Radiation Oncology

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Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

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Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density

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Tumor-Associated Macrophages: The Double-Edged Sword in Cancer Progression

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Predominant infiltration of macrophages and CD8⁺T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer

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Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression.

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Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

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Cytokines as a key component of cancer-related inflammation

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Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression

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Immunogenic cancer cell death: a key-lock paradigm

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Recruitment of Myeloid but not Endothelial Precursor Cells Facilitates Tumor Regrowth after Local Irradiation

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Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

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Cellular and molecular pathways linking inflammation and cancer

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CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis

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Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation

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Lymphocytes in cancer development: Polarization towards pro-tumor immunity

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Local Radiation Therapy Inhibits Tumor Growth through the Generation of Tumor-Specific CTL: Its Potentiation by Combination with Th1 Cell Therapy

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Macrophages From Irradiated Tumors Express Higher Levels of iNOS, Arginase-I and COX-2, and Promote Tumor Growth

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Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9–mediated progenitor cell mobilization

2005 • 223 citations

Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer

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Combination of Conformal Radiotherapy and Intratumoral Injection of Adoptive Dendritic Cell Immunotherapy in Refractory Hepatoma

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The Role of OX40-Mediated Co-stimulation in T-Cell Activation and Survival

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Heat Shock Proteins in Cancer

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Standard Treatments Induce Antigen-Specific Immune Responses in Prostate Cancer

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Blockade of Tumor Necrosis Factor α Signaling in Tumor-Associated Macrophages as a Radiosensitizing Strategy

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The Combination of Ionizing Radiation and Peripheral Vaccination Produces Long-term Survival of Mice Bearing Established Invasive GL261 Gliomas

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Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation

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Naturally occurring B-cell responses to breast cancer

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Targeting Toll-like Receptor 9 with CpG Oligodeoxynucleotides Enhances Tumor Response to Fractionated Radiotherapy

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Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice

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Identification of lymphocyte subpopulations in human breast cancer tissue and its significance: An immunoperoxidase study with anti-human t- and b-cell sera

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Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF- -dependent HIF-1 -mediated induction of CXCL12

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Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming

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Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis

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Applying the discovery of the Philadelphia chromosome

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Ionizing Radiation Affects Human MART-1 Melanoma Antigen Processing and Presentation by Dendritic Cells

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Immunogenic anti-cancer chemotherapy as an emerging concept

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Invariant Natural Killer T Cells Regulate Breast Cancer Response to Radiation and CTLA-4 Blockade

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Molecular markers of radiation-related normal tissue toxicity

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Transcriptional Mechanisms Regulating Alveolar Epithelial Cell-specific CCL5 Secretion in Pulmonary Tuberculosis

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Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancer

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Radiation induces an antitumour immune response to mouse melanoma

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Breast Cancer Overview

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Release of Interleukin-1 by Human Alveolar Macrophages after In Vitro Irradiation

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Combination Treatment of Murine Tumors by Adenovirus-Mediated Local B7/IL12 Immunotherapy and Radiotherapy

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Human Glioblastoma and Carcinoma Xenograft Tumors Treated by Combined Radiation and Imatinib (Gleevec®)

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The role of interleukin-3 in classical Hodgkin's disease

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Resistance of CD45RA− T Cells to Apoptosis and Functional Impairment, and Activation of Tumor-Antigen Specific T Cells during Radiation Therapy of Prostate Cancer

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Imatinib therapy reduces radiation-induced pulmonary mast cell influx and delays lung disease in the mouse

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Adenovirally Delivered Tumor Necrosis Factor-α Improves the Antiglioma Efficacy of Concomitant Radiation and Temozolomide Therapy

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Intratumoral Dendritic Cells and Chemoradiation for the Treatment of Murine Squamous Cell Carcinoma

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