Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

2009 • 1,232 citations

Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Cancer Research: Some Forward Steps

1965 • 733 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

2008 • 383 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

Stereotactic Body Radiation Therapy

2007 • 226 citations

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy

1999 • 223 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

2009 • 220 citations

Expression of lymphocyte-endothelial receptor-ligand pairs, alpha 4beta 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

1999 • 214 citations

Management of Small Soft-Tissue Sarcoma of the Extremity in Adults

1992 • 175 citations

Radiation induction of immediate early genes: Effectors of the radiation-stress response

1994 • 174 citations

Radiation Therapy for the Treatment of Unresected Stage I-II Non-small Cell Lung Cancer

2005 • 171 citations

Tumor Antigens are Constitutively Presented in the Draining Lymph Nodes

1999 • 170 citations

Immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: contrasting consequences of host versus tumor evolution.

1977 • 169 citations

Standard Treatments Induce Antigen-Specific Immune Responses in Prostate Cancer

2007 • 167 citations

Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

1999 • 167 citations

Transforming Growth Factor- and Wound Healing

2006 • 166 citations

OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor

2008 • 162 citations

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

2009 • 156 citations

Histologic assessment of peritumoral edema in soft tissue sarcoma

2005 • 155 citations

TREATMENT OF PRIMARY FIBROSARCOMA IN THE RAT WITH IMMUNE LYMPHOCYTES

1964 • 149 citations

Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-β–Insensitive CD8+ T Cells: Eradication of Autologous Mouse Prostate Cancer

2005 • 147 citations

Small Molecular Inhibitor of Transforming Growth Factor-β Protects Against Development of Radiation-Induced Lung Injury

2008 • 126 citations

The Molecular and Cellular Basis of Radiosensitivity: Implications for Understanding How Normal Tissues and Tumors Respond to Therapeutic Radiation

1999 • 113 citations

Functional Dichotomy between OX40 and 4-1BB in Modulating Effector CD8 T Cell Responses

2006 • 103 citations

Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of αOX-40 with αCTLA-4

2001 • 99 citations

Anti‐OX40 stimulation in vivo enhances CD8⁺ memory T cell survival and significantly increases recall responses

2006 • 95 citations

Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis.

1994 • 95 citations

Augmented antitumor effects of radiation therapy by 4-1BB antibody (BMS-469492) treatment.

2006 • 88 citations

Anti‐OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer

2008 • 88 citations

Defects in the Acquisition of CD8 T Cell Effector Function after Priming with Tumor or Soluble Antigen Can Be Overcome by the Addition of an OX40 Agonist

2007 • 87 citations

Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity.

1984 • 86 citations

OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen

2005 • 84 citations

Induction of Anti-Mammary Cancer Immunity by Engaging the OX-40 Receptor in Vivo

2001 • 80 citations

Does endogenous immune response determine the outcome of surgical therapy for metastatic melanoma?

2000 • 68 citations

Long-Term Outcome of Patients With American Joint Committee on Cancer Stage IIB Extremity Soft Tissue Sarcomas

1999 • 64 citations

Effect of Irradiation on Immune Responses

1976 • 53 citations

Ligation of the OX40 co‐stimulatory receptor reverses self‐Ag and tumor‐induced CD8 T‐cell anergy in vivo

2009 • 50 citations

Extremity soft-tissue sarcomas selectively treated with surgery alone

2000 • 45 citations

Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-β) receptor mediated by adenoviral vector

2004 • 40 citations

OX40 Ligation Enhances Cell Cycle Turnover of Ag-Activated CD4 T Cells in Vivo

2001 • 37 citations

Prevention of radiation-induced pneumonitis by recombinant adenovirus-mediated transferring of soluble TGF-β type II receptor gene

2006 • 31 citations

Changing concepts of cancer surgery: Surgery as immunotherapy

1978 • 27 citations

Expression of CD134 and CD134 ligand in lesional and nonlesional psoriatic skin

2002 • 16 citations

Reduced L-selectin (CD62LLow) expression identifies tumor-specific type 1 T cells from lymph nodes draining an autologous tumor cell vaccine

2004 • 11 citations

Adjuvant therapy for extremity sarcomas

2006 • 9 citations