Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

2002 • 5,109 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Hypoxia in cancer: significance and impact on clinical outcome

2007 • 2,062 citations

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1999 • 1,987 citations

HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

2003 • 1,909 citations

Regulation of immune responses by L-arginine metabolism

2005 • 1,636 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

2006 • 1,366 citations

Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

2004 • 1,136 citations

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

2003 • 1,049 citations

1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

1997 • 828 citations

Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene: A Transgenic Mouse Model for Metastatic Disease

1992 • 812 citations

l-arginine availability regulates T-lymphocyte cell-cycle progression

2006 • 801 citations

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

2006 • 798 citations

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

2000 • 784 citations

Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism

2002 • 657 citations

HIF-1α expression regulates the bactericidal capacity of phagocytes

2005 • 647 citations

Detection and Characterization of Tumor Hypoxia Using pO₂ Histography

2007 • 642 citations

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

2003 • 580 citations

The anticancer immune response: indispensable for therapeutic success?

2008 • 556 citations

Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

1995 • 553 citations

Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis

2010 • 545 citations

Determination of arginase activity in macrophages: a micromethod

1994 • 536 citations

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

2003 • 499 citations

Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway

1998 • 473 citations

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

2008 • 450 citations

In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1

1996 • 412 citations

Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes.

1991 • 402 citations

Suppression of T-cell functions by human granulocyte arginase

2006 • 385 citations

Pathways Mediating the Expansion and Immunosuppressive Activity of Myeloid-Derived Suppressor Cells and Their Relevance to Cancer Therapy

2007 • 265 citations

Improving T Cell Therapy for Cancer

2006 • 248 citations

Tumor-Induced Immune Dysfunctions Caused by Myeloid Suppressor Cells

2001 • 245 citations

Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.

1999 • 235 citations

Sustained Nitric Oxide Production in Macrophages Requires the Arginine Transporter CAT2

2001 • 225 citations

The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene.

1996 • 204 citations

Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice.

1993 • 176 citations

Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy

2007 • 157 citations

A Schistosome-Expressed Immunomodulatory Glycoconjugate Expands Peritoneal Gr1+ Macrophages That Suppress Naive CD4+ T Cell Proliferation Via an IFN-γ and Nitric Oxide-Dependent Mechanism

2001 • 151 citations

Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway

1991 • 135 citations

Inducible nitric oxide synthase in T cells regulates T cell death and immune memory

2004 • 112 citations

Nitric Oxide-Independent CTL Suppression during Tumor Progression: Association with Arginase-Producing (M2) Myeloid Cells

2003 • 108 citations

CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages.

1999 • 101 citations

Altered Immune Function during Long-Term Host-Tumor Interactions Can Be Modulated to Retard Autochthonous Neoplastic Growth

2007 • 80 citations

CAT2-mediated l-arginine transport and nitric oxide production in activated macrophages

1999 • 57 citations

Adjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide Synthase

2001 • 53 citations

Tumor-specific granulocyte/macrophage colony-stimulating factor and interferon ? secretion is associated with in vivo therapeutic efficacy of activated tumor-draining lymph node cells

1995 • 51 citations

Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung

2006 • 50 citations

Peritoneal macrophages suppress T‐cell activation by amino acid catabolism

2006 • 32 citations

Decreased macrophage‐mediated cytotoxicity in mammary‐tumor‐bearing mice is related to alteration of nitric‐oxide production and/or release

1995 • 30 citations