Regulation of Adaptive Immunity by the Innate Immune System

Dendritic cells and the control of immunity

1998 • 14,345 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Toll-like receptors in innate immunity

2004 • 3,233 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

The Inflammasomes: Guardians of the Body

2009 • 2,308 citations

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

2005 • 1,741 citations

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

2005 • 1,360 citations

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

Innate immunity to virus infection

2008 • 1,161 citations

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

2008 • 1,161 citations

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

2009 • 1,107 citations

Dectin-1: a signalling non-TLR pattern-recognition receptor

2005 • 1,083 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

2008 • 1,053 citations

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

2009 • 1,024 citations

Intracellular NOD-like Receptors in Host Defense and Disease

2007 • 1,008 citations

The immune geography of IgA induction and function

2007 • 944 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

2009 • 839 citations

Toll-dependent selection of microbial antigens for presentation by dendritic cells

2006 • 815 citations

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

2005 • 794 citations

Pattern recognition receptors and control of adaptive immunity

2008 • 713 citations

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

2006 • 700 citations

Activation of innate immune antiviral responses by Nod2

2009 • 682 citations

Innate Recognition of Viruses

2007 • 671 citations

A cell biological view of Toll-like receptor function: regulation through compartmentalization

2009 • 666 citations

Inflammasome recognition of influenza virus is essential for adaptive immune responses

2009 • 662 citations

Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 4

2002 • 648 citations

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor- viral RNA interactions

2005 • 643 citations

Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

2005 • 616 citations

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

2009 • 605 citations

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

2008 • 604 citations

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

2007 • 497 citations

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

2008 • 485 citations

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

2009 • 435 citations

An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells

2001 • 431 citations

Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity

2004 • 430 citations

Innate and Adaptive Immunity through Autophagy

2007 • 406 citations

Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease

2007 • 373 citations

Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2

2007 • 362 citations

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

2009 • 348 citations

Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity

2007 • 317 citations

Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

2007 • 303 citations

Innate recognition of bacteria by a macrophage cytosolic surveillance pathway

2002 • 282 citations

Role of Dendritic Cell Targeting in Venezuelan Equine Encephalitis Virus Pathogenesis

2000 • 261 citations

Pillars article: approaching the asymptote? Evolution and revolution in immunology. Cold spring harb symp quant biol. 1989. 54: 1-13.

2013 • 248 citations

Structural Mechanism of RNA Recognition by the RIG-I-like Receptors

2008 • 245 citations

Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity

2004 • 153 citations

Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses

2008 • 151 citations

MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus

2008 • 141 citations

Toll-like Receptor Recognition Regulates Immunodominance in an Antimicrobial CD4+ T Cell Response

2006 • 132 citations

TLR9 Is Required for the Gut-Associated Lymphoid Tissue Response following Oral Infection of Toxoplasma gondii

2006 • 128 citations

Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments

2004 • 114 citations

In vivo antigen presentation

2003 • 84 citations

Cutting Edge: Protective Cell-Mediated Immunity to Listeria monocytogenes in the Absence of Myeloid Differentiation Factor 88

2003 • 78 citations

Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-α/β

2008 • 74 citations

MyDths and un-TOLLed truths: Sensor, instructive and effector immunity to tuberculosis

2008 • 58 citations

Myd88 Is Required for an Antibody Response to Retroviral Infection

2009 • 48 citations

Human immunodeficiency virus‐1 acquisition in genital mucosa: Langerhans cells as key‐players

2008 • 42 citations

Connections between antiviral defense and autoimmunity

2009 • 29 citations