HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons.

Current protocols in molecular biology

1988 • 4,543 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

[6] Quantitation of protein

1990 • 1,401 citations

The Interferon System

1979 • 1,035 citations

[36] Eukaryotic gene transcription with purified components

1983 • 992 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Electroporation for the efficient transfection of mammalian cells with DNA

1987 • 856 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

1989 • 781 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

Activators and targets

1990 • 582 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers

1993 • 506 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Detailed analysis of the mouse H-2Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression

1986 • 395 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

1990 • 332 citations

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

1989 • 292 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.

1985 • 255 citations

Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H–2 gene

1986 • 252 citations

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.

1992 • 247 citations

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.

1992 • 245 citations

Interferon-induced transcription of a major histocompatibility class I gene accompanies binding of inducible nuclear factors to the interferon consensus sequence.

1988 • 170 citations

Antigen Presentation Requires Transport of MHC Class I Molecules from the Endoplasmic Reticulum

1990 • 167 citations

Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons.

1988 • 142 citations

A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.

1989 • 113 citations

Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either

1990 • 110 citations

Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium.

1990 • 109 citations

Occupancy of upstream regulatory sites in vivo coincides with major histocompatibility complex class I gene expression in mouse tissues.

1992 • 76 citations

Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation

1989 • 76 citations

Interaction at a distance between λrepressers disrupts gene activation

1988 • 73 citations

Inducible processing of interferon regulatory factor-2.

1992 • 69 citations

Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression.

1992 • 68 citations

Molecular Organization of the Class I Genes of Human Major Histocompatibility Complex

1985 • 62 citations

Identification of cis Sequences Controlling Efficient PositionIndependent Tissue-Specific Expression of Human Major Histocompatibility Complex Class I Genes in Transgenic Mice

1991 • 53 citations

Differential regulation of HLA-A3 and HLA-B7 MHC class I genes by IFN is due to two nucleotide differences in their IFN response sequences.

1991 • 52 citations

Transcripts of human HLA gene fragments lacking the 5'-terminal region in transfected mouse cells.

1984 • 48 citations

Multiple enhancer-like sequences in the HLA-B7 gene.

1989 • 36 citations

Nucleotide sequence of an HLA-A1 gene

1990 • 36 citations

Differential expression and interferon response of HLA class I genes in thymocyte lines and response variants

1988 • 33 citations

Two upstream elements activate transcription of a major histocompatibility complex class I genein vitro

1992 • 31 citations

Phased cis-acting promoter elements interact at short distances to direct avian skeletal alpha-actin gene transcription.

1991 • 31 citations

Nucleotide sequence of an HLA-Bw57 gene

1990 • 29 citations

Promoter region ofHLA-C genes: regulatory elements common to and different from those ofHLA-A andHLA-B genes

1990 • 25 citations

Occupancy of Upstream Regulatory Sites In Vivo Coincides with Major Histocompatibility Complex Class I Gene Expression in Mouse Tissues

1992 • 18 citations

Inducible Processing of Interferon Regulatory Factor-2

1992 • 13 citations