Immunogenic cancer cell death: a key-lock paradigm

The biochemistry of apoptosis

2000 • 7,314 citations

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

2008 • 3,166 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

2007 • 2,297 citations

A blast from the past: clearance of apoptotic cells regulates immune responses

2002 • 1,558 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

2005 • 1,331 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

2007 • 1,306 citations

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

2005 • 1,246 citations

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

2001 • 1,122 citations

High mobility group box 1 protein interacts with multiple Toll-like receptors

2005 • 905 citations

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

2007 • 838 citations

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

2005 • 795 citations

Cell death modalities: classification and pathophysiological implications

2007 • 772 citations

Caspase-independent cell death

2005 • 699 citations

The anticancer immune response: indispensable for therapeutic success?

2008 • 556 citations

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

2007 • 531 citations

The extracellular release of HMGB1 during apoptotic cell death

2006 • 509 citations

Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products

2005 • 498 citations

RAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages

2005 • 485 citations

High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization

2004 • 435 citations

Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications

2007 • 367 citations

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

2008 • 319 citations

Activation of Poly(ADP)-ribose Polymerase (PARP-1) Induces Release of the Pro-inflammatory Mediator HMGB1 from the Nucleus

2007 • 193 citations

Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells

2005 • 193 citations

Ecto‐calreticulin in immunogenic chemotherapy

2007 • 187 citations

SREC-I, a Type F Scavenger Receptor, Is an Endocytic Receptor for Calreticulin

2004 • 138 citations

Immune Response Against Dying Tumor Cells

2004 • 121 citations

Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin

2007 • 110 citations

Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages

2004 • 110 citations

Immunotherapy for human cancer using heat shock protein-peptide complexes

2005 • 100 citations

Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation

2007 • 88 citations

After shrinkage apoptotic cells expose internal membrane-derived epitopes on their plasma membranes

2006 • 85 citations

Scavenger Receptor-A Negatively Regulates Antitumor Immunity

2007 • 77 citations

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance

2008 • 75 citations

Enhanced expression of heat shock proteins in gradually dying cells and their release from necrotically dead cells

2005 • 69 citations

Localized Hyperthermia Combined with Intratumoral Dendritic Cells Induces Systemic Antitumor Immunity

2007 • 63 citations

Glucose-Regulated Protein 94/Glycoprotein 96 Elicits Bystander Activation of CD4+ T Cell Th1 Cytokine Production In Vivo

2004 • 58 citations

Chaperon and Adjuvant Activity of hsp70: Different Natural Killer Requirement for Cross-Priming of Chaperoned and Bystander Antigens

2005 • 46 citations

Extracellular Targeting of Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 170 Enhances Tumor Immunity to a Poorly Immunogenic Melanoma

2006 • 44 citations

Interaction of Calreticulin with CD40 Ligand, TRAIL and Fas Ligand

2007 • 25 citations

Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis

2007 • 19 citations

Calreticulin requires an ancillary adjuvant for the induction of efficient cytotoxic T cell responses

2007 • 16 citations

Identification of a Novel Cancer-Testis Antigen CRT2 Frequently Expressed in Various Cancers Using Representational Differential Analysis

2007 • 15 citations