Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element.

Adhesion receptors of the immune system

1990 • 6,585 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

The biology of interleukin-6

1989 • 1,964 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

The biology of interleukin-6

1989 • 1,459 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

1988 • 967 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

1990 • 898 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

1993 • 766 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines.

1989 • 614 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies.

1988 • 569 citations

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway

1993 • 548 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

1992 • 530 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Molecular cloning and expression of the human interferon-γ receptor

1988 • 481 citations

ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains.

1990 • 475 citations

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester.

1991 • 419 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines

1993 • 367 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

Interferons and other regulatory cytokines

1989 • 306 citations

Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei

1993 • 285 citations

12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter.

1994 • 266 citations

Intercellular adhesion molecule-1 gene expression in human endothelial cells. Differential regulation by tumor necrosis factor-alpha and phorbol myristate acetate.

1992 • 262 citations

A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter.

1993 • 256 citations

Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter.

1988 • 222 citations

The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.

1993 • 184 citations

Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene.

1990 • 177 citations

Cloning and characterization of the 5'-transcriptional regulatory region of the human intercellular adhesion molecule 1 gene

1991 • 171 citations

Recombinant human interleukin 6 (B‐cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1)

1988 • 166 citations

Induction of ICAM-1 by TNF-alpha, IL-1 beta, and LPS in human endothelial cells after downregulation of PKC

1992 • 162 citations

The Human β Fibrinogen Promoter Contains a Hepatocyte Nuclear Factor 1-Dependent Interleukin-6-Responsive Element

1993 • 149 citations

Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma.

1991 • 147 citations

Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter.

1993 • 131 citations

Glucocorticoid-mediated Repression of Intercellular Adhesion Molecule-1 Expression in Human Monocytic and Bronchial Epithelial Cell Lines

1993 • 116 citations

Interferon gamma rapidly induces in human monocytes a DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high-affinity Fc gamma receptor.

1992 • 114 citations

Induction of HLA class II genes by IFN-gamma is transcriptional and requires a trans-acting protein.

1989 • 113 citations

A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.

1989 • 113 citations

Molecular interactions in macrophage activation

1989 • 102 citations

Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice

1990 • 101 citations

Regulation of the expression of ICAM-1 on human monocytes and monocytic tumor cell lines.

1992 • 99 citations

In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.

1993 • 92 citations

Phage Particle-Mediated Gene Transfer to Cultured Mammalian Cells

1982 • 79 citations

Structural Characteristics of the 5′ Region of the Human ICAM-1 Gene

1990 • 77 citations

Nuclear factors interacting with an interleukin-6 responsive element of rat α₂-macroglobulin gene

1989 • 68 citations

In vitro activation of the transcription factor gamma interferon activation factor by gamma interferon: evidence for a tyrosine phosphatase/kinase signaling cascade.

1993 • 67 citations

Immune modulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human hepatocytic cell lines

1993 • 58 citations

The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage.

1993 • 57 citations

Synergism of interleukin 6 and 1α,25-dihydroxyvitamin D3 in induction of myeloid differentiation of human leukemic cell lines

1992 • 31 citations

Dominant negative retinoic acid receptor β

1993 • 22 citations