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The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects

Data up to Jan 2025

Published2002
Citations236
References195

Total Citations Per Year

Abstract

References (195)

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Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

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Arsenic induces oxidant stress and NF-KB activation in cultured aortic endothelial cells

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Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis

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Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite

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1998 • 259 citations

Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

2000 • 258 citations

Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells

1998 • 253 citations

Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-xL

2000 • 242 citations

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1993 • 231 citations

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients.

1999 • 228 citations

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1998 • 228 citations

Retinoids in chemoprevention and differentiation therapy

2000 • 222 citations

The Stress Inducer Arsenite Activates Mitogen-activated Protein Kinases Extracellular Signal-regulated Kinases 1 and 2 via a MAPK Kinase 6/p38-dependent Pathway

1998 • 211 citations

Differential activation of ERK, JNK/SAPK and P3/CSBP/RK map kinase family members during the cellular response to arsenite

1996 • 211 citations

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1989 • 210 citations

Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells.

1999 • 208 citations

Arsenic Species That Cause Release of Iron from Ferritin and Generation of Activated Oxygen

2000 • 208 citations

Arsenic Enhancement of Skin Neoplasia by Chronic Stimulation of Growth Factors

1998 • 206 citations

Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.

1997 • 198 citations

Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation.

2000 • 196 citations

Mechanisms Controlling the Transcription of Matrix Metalloproteinase Genes in Normal and Neoplastic Cells

1996 • 194 citations

The Role of Oxidative DNA Damage in Human Arsenic Carcinogenesis: Detection of 8-Hydroxy-2′-Deoxyguanosine in Arsenic-Related Bowen's Disease

1999 • 194 citations

Retinoic acid (RA) and As 2 O 3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins

2000 • 193 citations

Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats

1999 • 191 citations

Low Levels of Arsenic Trioxide Stimulate Proliferative Signals in Primary Vascular Cells without Activating Stress Effector Pathways

1999 • 188 citations

Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro

1999 • 188 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.

1999 • 183 citations

Essential role of p53 in phenethyl isothiocyanate-induced apoptosis.

1998 • 181 citations

Arsenic Trioxide and Interferon- Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I–Transformed Cells

1999 • 181 citations

DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells

2000 • 178 citations

Leukocytosis and the Retinoic Acid Syndrome in Patients With Acute Promyelocytic Leukemia Treated With Arsenic Trioxide

2000 • 171 citations

Confounding variables in the environmental toxicology of arsenic

2000 • 169 citations

Requirement of Erk, but Not JNK, for Arsenite-induced Cell Transformation

1999 • 168 citations

Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals

1999 • 167 citations

The role of ATM in DNA damage responses and cancer

1998 • 165 citations

Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells

1998 • 160 citations

Tumor Promoter Arsenite Activates Extracellular Signal-Regulated Kinase through a Signaling Pathway Mediated by Epidermal Growth Factor Receptor and Shc

1998 • 155 citations

Metallothionein-I/II Null Mice Are More Sensitive than Wild-Type Mice to the Hepatotoxic and Nephrotoxic Effects of Chronic Oral or Injected Inorganic Arsenicals

2000 • 151 citations

Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors

1997 • 149 citations

Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide

1999 • 147 citations

Arsenic-interferon-α–triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-κB activation

2000 • 146 citations

Arsenic induces overexpression of growth factors in human keratinocytes

1996 • 143 citations

Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation.

1998 • 143 citations

Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts.

2000 • 142 citations

DMPS–Arsenic Challenge Test

2000 • 137 citations

Enzymatic Reduction of Arsenic Compounds in Mammalian Systems: Reduction of Arsenate to Arsenite by Human Liver Arsenate Reductase

1999 • 129 citations

Arsenic induces apoptosis in B‐cell leukaemic cell lines in vitro: activation of caspases and down‐regulation of Bcl‐2 protein

1998 • 129 citations

Mechanisms of arsenic carcinogenicity: genetic or epigenetic mechanisms?

2000 • 128 citations

The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival.

1998 • 125 citations

Arsenite Induces Apoptosis of Murine T Lymphocytes Through Membrane Raft-Linked Signaling for Activation of c-Jun Amino-Terminal Kinase

2000 • 122 citations

Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis

2000 • 121 citations

Metals and Disorders of Cell Accumulation: Modulation of Apoptosis and Cell Proliferation

2000 • 116 citations

Arsenic Inhibits NF-κB-mediated Gene Transcription by Blocking IκB Kinase Activity and IκBα Phosphorylation and Degradation

2000 • 114 citations

Sodium Arsenite-Induced Dysregulation of Proteins Involved in Proliferative Signaling

2000 • 112 citations

Phosphatidylinositol-3 Kinase Is Necessary for 12-O-Tetradecanoylphorbol-13-acetate-induced Cell Transformation and Activated Protein 1 Activation

1997 • 112 citations

Comparative Activity of Melarsoprol and Arsenic Trioxide in Chronic B-Cell Leukemia Lines

1997 • 112 citations

Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice

2000 • 104 citations

Cell Stress and MKK6b-mediated p38 MAP Kinase Activation Inhibit Tumor Necrosis Factor-induced IκB Phosphorylation and NF-κB Activation

1999 • 101 citations

Studies on the Mechanisms of Arsenic-Induced Self Tolerance Developed in Liver Epithelial Cells through Continuous Low-Level Arsenite Exposure

2000 • 90 citations

Induction of p53 protein expression by sodium arsenite

1997 • 89 citations

Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: a review.

2000 • 89 citations

Sodium arsenite disturbs mitosis and induces chromosome loss in human fibroblasts.

1997 • 88 citations

Effect of Glutathione Depletion and Metallothionein Gene Expression on Arsenic-Induced Cytotoxicity and c-mycExpressionin Vitro

1998 • 88 citations

Arsenic in Drinking Water and Bladder Cancer: Environmental Carcinogenesis

2000 • 87 citations

Signal transduction pathways regulated by arsenate and arsenite

1999 • 87 citations

The alteration of mitochondria is an early event of arsenic trioxide induced apoptosis in esophageal carcinoma cells.

2000 • 86 citations

Monomethylarsonic Acid Reductase and Monomethylarsonous Acid in Hamster Tissue

2000 • 84 citations

Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases

1999 • 81 citations

Arsenic Disrupts Cellular Levels of p53 and mdm2: A Potential Mechanism of Carcinogenesis

1999 • 81 citations

Effect of Arsenic Trioxide on Cell Cycle Arrest in Head and Neck Cancer Cell Line PCI-1

1999 • 78 citations

Acute promyelocytic leukemia: Cellular and molecular basis of differentiation and apoptosis

1997 • 77 citations

BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity.

2000 • 77 citations

Is the Human Carcinogen Arsenic Carcinogenic to Laboratory Animals?

2000 • 76 citations

Arsenite induces DNA-protein crosslinks and cytokeratin expression in the WRL-68 human hepatic cell line

2000 • 75 citations

Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression

1999 • 75 citations

Different Mechanisms of c-Jun NH2-terminal Kinase-1 (JNK1) Activation by Ultraviolet-B Radiation and by Oxidative Stressors

1999 • 74 citations

Effects of dietary dimethylarsinic acid on the urine and urothelium of rats

1999 • 73 citations

Sodium Arsenite Reduces Proliferation of Human Activated T-Cells by Inhibition of the Secretion of Interleukin-2

1999 • 73 citations

Arsenic-Induced Apoptosis in Malignant CellsIn vitro

2000 • 72 citations

Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines

1999 • 70 citations

Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices

1999 • 69 citations

Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan

1999 • 69 citations

The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice

2000 • 67 citations

Arsenic Trioxide Inhibits Neuroblastoma Growth in Vivo and Promotes Apoptotic Cell Death in Vitro

2000 • 67 citations

Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding

1999 • 66 citations

Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines

1997 • 66 citations

Dithiothreitol Enhances Arsenic Trioxide-Induced Apoptosis in NB4 Cells

1999 • 61 citations

Arsenic trioxide induces apoptosis of oesophageal carcinoma in vitro.

1999 • 60 citations

Expression of p53 in Arsenic-Related and Sporadic Basal Cell Carcinoma

2000 • 60 citations

Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice

2000 • 60 citations

Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis, and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment, and cell cycle phase.

2000 • 58 citations

Arsenicals in hematologic cancers.

2000 • 57 citations

Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis

1999 • 56 citations

PROGRESSIVE ELEVATION OF AP-1 ACTIVITY DURING PRENEOPLASTIC-TO-NEOPLASTIC PROGRESSION AS MODELED IN MOUSE JB6 CELL VARIANTS

1995 • 56 citations

Effects of exposure protocols on induction of kinetochore-plus and -minus micronuclei by arsenite in diploid human fibroblasts

1999 • 53 citations

Predisposing factors in occupational lung cancer: inorganic minerals and chromium.

2000 • 53 citations

Sodium Arsenite Inhibits Terminal Differentiation of Murine C3H 10T1/2 Preadipocytes

2000 • 51 citations

Responses of Preneoplastic Epidermal Cells to Tumor Promoters and Growth Factors: Use of Promoter‐Resistant Variants for Mechanism Studies

1982 • 48 citations

Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice

2000 • 48 citations

Activation of PKC is required for arsenite-induced signal transduction.

2000 • 46 citations

Inhibition of arsenite-induced apoptosis and AP-1 activity by epigallocatechin-3-gallate and theaflavins.

2000 • 45 citations

Current issues in the management of acute promyelocytic leukemia

2000 • 45 citations

c-fosInduction by Heat, Arsenite, and Cadmium Is Mediated by a Heat Shock Element in Its Promoter

1999 • 44 citations

No point mutation of ha‐ras or p53 genes expressed in preneoplastic‐to‐neoplastic progression as modeled in mouse JB6 cell variants

1993 • 44 citations

The use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia.

2000 • 40 citations

Induction of mitosis-mediated apoptosis by sodium arsenite in HeLa S3 cells

2000 • 40 citations

Expression of bcl‐2, p53 and Ki‐67 in arsenical skin cancers

1998 • 40 citations

Infrequent p53 mutations in arsenic-related skin lesions.

1998 • 37 citations

In vitro tissue specificity for arsine and arsenite toxicity in the rat

1999 • 36 citations

Arsenic Trioxide Therapy for Relapsed Acute Promyelocytic Leukemia: an Useful Salvage Therapy

2000 • 36 citations

The Effects Of Arsenic Trioxide (As2O3) On Human Megakaryocytic Leukemia Cell Lines With a Comparison of its Effects on Other Cell Lineages

2000 • 35 citations

Retinoic Acid Syndrome Induced by Arsenic Trioxide in Treating Recurrent All-Trans Retinoic Acid Resistant Acute Promyelocytic Leukemia

2000 • 34 citations

Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancers

2000 • 32 citations

Effects of arsenic on blast transformation and DNA synthesis of human blood lymphocytes

2000 • 29 citations

Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia

1999 • 28 citations

Arsenic Trioxide and the Growth of Human T-cell Leukemia Virus Type I Infected T-cell Lines

2000 • 28 citations

Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos

1998 • 27 citations

Pathologic, Cytogenetic and Molecular Assessment of Acute Promyelocytic Leukemia Patients Treated with Arsenic Trioxide (As2O3)

2000 • 25 citations

72-kDa Stress Protein (Hsp72) Induced by Administration of Dimethylarsinic Acid to Mice Accumulates in Alveolar Flat Cells of Lung, a Target Organ for Arsenic Carcinogenesis.

2000 • 25 citations

Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity

2000 • 23 citations

Biology and treatment of acute progranulocytic leukemia

1999 • 22 citations

As2O3 induces apoptosis of the human B lymphoma cell line MBC-1.

2000 • 22 citations

Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure

1999 • 20 citations

Recent advances in the treatment of acute leukemia

1997 • 17 citations

Recent advances in the treatment of acute leukemia: 1999

2000 • 15 citations

[Antitumor effect of arsenic trioxide on mice experimental liver cancer].

2000 • 11 citations

Successful Treatment of All-Trans Retinoic Acid Resistant and Chemotherapy Naive Acute Promyelocytic Patients with Arsenic Trioxid-e - Two Case Reports

2000 • 11 citations

Sodium arsenite-induced chromosomal aberrations in the Xq arm of Chinese hamster cell lines

1998 • 8 citations

Deleted Work

1955 • 0 citations

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