Retinoids in chemoprevention and differentiation therapy

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN

1925 • 1,630 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor

1995 • 1,064 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

Recent Advances in Chemoprevention of Cancer

1997 • 837 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

IMPACT OF VITAMIN A SUPPLEMENTATION ON CHILDHOOD MORTALITY

1986 • 684 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

1993 • 658 citations

Transport and Storage of Vitamin A

1990 • 618 citations

Vitamin A in Health and Disease

1994 • 602 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 474 citations

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion

1996 • 463 citations

APMLRARα transgene initiates murine acute promyelocytic leukemia

1997 • 455 citations

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

1992 • 441 citations

Retinoids in cancer chemoprevention

1996 • 432 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

Suppression of Retinoic Acid Receptor–β in Premalignant Oral Lesions and Its Up-Regulation by Isotretinoin

1995 • 419 citations

Randomized Trial of Fenretinide to Prevent Second Breast Malignancy in Women With Early Breast Cancer

1999 • 416 citations

cDNA Cloning of Human Retinoic Acid-metabolizing Enzyme (hP450RAI) Identifies a Novel Family of Cytochromes P450 (CYP26)

1997 • 390 citations

PML induces a novel caspase-independent death process

1998 • 384 citations

Retinoic acid biosynthesis and metabolism

1996 • 384 citations

All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia [see comments]

1995 • 379 citations

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

1997 • 373 citations

Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos

1997 • 362 citations

Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells

1998 • 355 citations

HSV-1 IE protein Vmw110 causes redistribution of PML.

1994 • 354 citations

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)

1995 • 352 citations

Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

1995 • 332 citations

Evidence for Covalent Modification of the Nuclear Dot–associated Proteins PML and Sp100 by PIC1/SUMO-1

1997 • 329 citations

Perspectives on Cancer Chemoprevention Research and Drug Development

1999 • 318 citations

Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.

1996 • 307 citations

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

1992 • 280 citations

Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia

1997 • 279 citations

Plasma Retinol-Binding Protein

1984 • 270 citations

Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

1995 • 261 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 210 citations

Suppression of Retinoic Acid Receptor in Non-Small-Cell Lung Cancer In Vivo: Implications for Lung Cancer Development

1997 • 204 citations

Chemoprevention of Mammary Carcinogenesis in the Rat: Combined Use of Raloxifene and 9-cis-Retinoic Acid

1996 • 172 citations

The Involvement of Aryl Hydrocarbon Receptor in the Activation of Transforming Growth Factor-β and Apoptosis

1998 • 154 citations

Characterization of a plasma retinol-binding protein membrane receptor expressed in the retinal pigment epithelium

1992 • 131 citations

Biosynthesis and Metabolism of Retinoic Aid: Roles of CRBP and CRABP in Retinoic Acid: Roles of CRBP and CRABP in Retinoic Acid Homeostasis

1993 • 128 citations

Identification and Characterization of a Versatile Retinoid Response Element (Retinoic Acid Receptor Response Element-Retinoid X Receptor Response Element) in the Mouse Tissue Transglutaminase Gene Promoter

1996 • 124 citations

Acute promyelocytic leukemia: a curable disease

1998 • 121 citations

Molecular Epidemiology and Retinoid Chemoprevention of Head and Neck Cancer

1997 • 117 citations

Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis

1998 • 101 citations

Disruption of PML-associated nuclear bodies during human cytomegalovirus infection

1995 • 96 citations

Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

1995 • 90 citations

Vitamin A Deficiency enhances Binding of Benzo(a)pyrene to Tracheal Epithelial DNA

1974 • 89 citations

Distribution of fenretinide in the mammary gland of breast cancer patients

1991 • 84 citations

PATHOGENESIS AND MANAGEMENT OF ACUTE PROMYELOCYTIC LEUKEMIA

1996 • 67 citations

Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein

1998 • 56 citations

A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias.

1996 • 55 citations

Targeting the PML/RARα translocation product triggers apoptosis in promyelocytic leukemia cells

1998 • 47 citations

Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis

1997 • 43 citations

Comparison of the Uptake and Metabolism of Retinol Delivered to Primary Mouse Keratinocytes Either Free or Bound to Rat Serum Retinol-binding Protein

1989 • 42 citations

Chemoprevention Trial of Contralateral Breast Cancer with Fenretinide. Rationale, Design, Methodology, Organization, Data Management, Statistics and Accrual

1997 • 36 citations

Differentiation therapy of leukemia: achievements, limitations and future prospects.

1998 • 35 citations

Acute promyelocytic leukemia. A childhood cluster

1987 • 33 citations

Regional Delivery of Retinoids: A New Approach to Early Lung Cancer Intervention

1998 • 32 citations

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 28 citations

Vitamin A, Retinoids and Breast Cancer

1994 • 27 citations

Retinoic acid nuclear receptors and tumor promotion: decreased expression of retinoic acid nuclear receptors by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate

1994 • 27 citations

High dietary retinoic acid prevents malignant conversion of skin papillomas induced by a two-stage carcinogenesis protocol in female SENCAR mice

1994 • 25 citations

The role of vitamin A in differentiation and skin carcinogenesis

1997 • 24 citations

Metabolism of the chemopreventive retinoid N-(4-hydroxyphenyl)retinamide by mammary gland in organ culture

1988 • 22 citations

Synthesis of LIAZALTM, a retinoic acid metabolism blocking agent (ramba) with potential clinical applications in oncology and dermatology

1998 • 20 citations

High dietary retinoic acid inhibits tumor promotion and malignant conversion in a two-stage skin carcinogenesis protocol using 7,12-dimethylbenz[a]anthracene as the initiator and mezerein as the tumor promoter in female SENCAR mice

1995 • 18 citations

Retinoic acid and 4-hydroxyphenylretinamide induce growth inhibition and tissue transglutaminase through different signal transduction pathways in mouse fibroblasts (NIH 3T3 cells)

1999 • 17 citations

Retinoid Binding in Normal and Neoplastic Mammary Tissue

1982 • 16 citations

Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

1998 • 12 citations

Vitamin A

1978 • 4 citations

Probing the pathobiology of response to all-trans retinoic acid in acute promyelocytic leukemia: premature chromosome condensation/fluorescence in situ hybridization analysis

1996 • 2 citations