Arsenic Trioxide and the Growth of Human T-cell Leukemia Virus Type I Infected T-cell Lines

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Principles of CDK regulation

1995 • 3,267 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphoma

1991 • 1,527 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

1999 • 538 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Absence of WAF1 mutations in a variety of human malignancies

1994 • 390 citations

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

1996 • 299 citations

Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations

1999 • 281 citations

A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells.

1996 • 229 citations

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients.

1999 • 228 citations

A novel T-cell line derived from adult T-cell leukemia.

1980 • 224 citations

Mutations of the p53 gene in adult T-cell leukemia

1992 • 223 citations

Arsenic Trioxide and Interferon- Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I–Transformed Cells

1999 • 181 citations

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia

1995 • 175 citations

The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms

1998 • 159 citations

Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T- cell leukemia/lymphoma

1995 • 134 citations

Acute and chronic arsenic poisoning associated with treatment of acute promyelocytic leukaemia

1998 • 133 citations

A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells.

1981 • 132 citations

Optimal detection of apoptosis by flow cytometry depends on cell morphology

1993 • 127 citations

Expression of P-glycoprotein in adult T-cell leukemia cells

1990 • 119 citations

Comparative Activity of Melarsoprol and Arsenic Trioxide in Chronic B-Cell Leukemia Lines

1997 • 112 citations

Involvement of Bcl-2 Cleavage in the Acceleration of VP-16-Induced U937 Cell Apoptosis

1998 • 79 citations

Retrovirus Biology and Human Disease

1991 • 69 citations

Aberrant Expression of the p53 Tumor Suppressor Gene in Adult T‐Cell Leukemia and HTLV‐I‐infected Cells

1993 • 64 citations

Arsenic trioxide inhibits growth of human T‐cell leukaemia virus type I infected T‐cell lines more effectively than retinoic acids

1998 • 57 citations

Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes

1999 • 56 citations

Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)

1997 • 40 citations

Enhanced MDR1 Gene Expression in Human T-Cell Leukemia Virus-I–Infected Patients Offers New Prospects for Therapy

1998 • 32 citations

Cell cycle inhibition of HTLV-I transformed T cell lines by retinoic acid: the possible therapeutic use of thioredoxin reductase inhibitors.

1995 • 30 citations

Treatment for adult T-cell leukemia

1997 • 11 citations