Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

1997 • 808 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1993 • 602 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

1999 • 538 citations

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

1995 • 501 citations

Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis

1997 • 485 citations

Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis

1998 • 473 citations

Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells

1998 • 355 citations

Metal carcinogenesis: Mechanistic implications

1992 • 348 citations

Signalling mechanisms and oxidative stress in apoptosis

1995 • 306 citations

The role of intracellular oxidants in apoptosis

1995 • 294 citations

Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations

1999 • 281 citations

Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.

1997 • 277 citations

Requirement of Caspase-3(-like) Protease-mediated Hydrogen Peroxide Production for Apoptosis Induced by Various Anticancer Drugs

1998 • 271 citations

Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

1998 • 254 citations

Arsenite induces apoptosis in chinese hamster ovary cells by generation of reactive oxygen species

1996 • 241 citations

Mitochondrial Membrane Potential and Nuclear Changes in Apoptosis Caused by Serum and Nerve Growth Factor Withdrawal: Time Course and Modification by (−)-Deprenyl

1998 • 232 citations

Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor Cytochrome c

1998 • 216 citations

Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function

1997 • 214 citations

The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

1996 • 206 citations

Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B

1998 • 192 citations

Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells

1997 • 192 citations

The Thiol-specific Antioxidant Enzyme Prevents Mitochondrial Permeability Transition

1998 • 174 citations

Design of an epidemiologic study of drinking water arsenic exposure and skin and bladder cancer risk in a U.S. population.

1998 • 170 citations

A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα Mutation

1997 • 159 citations

The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms

1998 • 159 citations

Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy (review).

1998 • 158 citations

Glutathione peroxidase and catalase modulate the genotoxicity of arsenite

1997 • 132 citations

Arsenic induces apoptosis in B‐cell leukaemic cell lines in vitro: activation of caspases and down‐regulation of Bcl‐2 protein

1998 • 129 citations

Elevation of glutathione levels and glutathione S-transferase activity in arsenic-resistant chinese hamster ovary cells

1989 • 117 citations

TGF-β1 Triggers Oxidative Modifications and Enhances Apoptosis in Hit Cells Through Accumulation of Reactive Oxygen Species by Suppression of Catalase and Glutathione Peroxidase

1997 • 108 citations

Selenium–Glutathione Peroxidase: Properties and Synthesis

1984 • 98 citations

Selective Inhibitory Effect of Bufalin on Growth of Human Tumor Cells in vitro: Association with the Induction of Apoptosis in Leukemia HL‐60 Cells

1994 • 89 citations

Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase

1996 • 88 citations

Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation

1993 • 77 citations

Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line

1989 • 71 citations

Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase

1996 • 70 citations

Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines.

1996 • 69 citations

Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation.

1992 • 65 citations

Glutathione S-Transferase π Facilitates the Excretion of Arsenic from Arsenic-Resistant Chinese Hamster Ovary Cells

1993 • 61 citations

The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms

2000 • 61 citations

Genomic Cloning of hGSTP1*C, an Allelic Human Pi Class Glutathione S-Transferase Gene Variant and Functional Characterization of Its Retinoic Acid Response Elements

1997 • 52 citations

Selective induction of apoptosis of NB4 cells from G2+M phase by sodium arsenite at lower doses

1998 • 42 citations

Design of an Epidemiologic Study of Drinking Water Arsenic Exposure and Skin and Bladder Cancer Risk in a U.S. Population

1998 • 41 citations

The t(15;17) translocation in acute promyelocytic leukemia.

1994 • 39 citations

Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants

1994 • 28 citations

Effect of retinoic acid on adenosine diphosphate and collagen-induced alterations in enzymes of GSH-linked antioxidant defence system of human blood platelets in vitro.

1990 • 4 citations

Deleted Work

1955 • 0 citations

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