Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

BACTERIAL HEAVY METAL RESISTANCE: New Surprises

1996 • 1,263 citations

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

1997 • 808 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Acute Promyelocytic Leukemia

2015 • 764 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1993 • 602 citations

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression

1997 • 554 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.

1994 • 492 citations

APMLRARα transgene initiates murine acute promyelocytic leukemia

1997 • 455 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.

1996 • 419 citations

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

1997 • 373 citations

Acute leukemia with promyelocytic features in PML/RARα transgenic mice

1997 • 366 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

Transcriptional Activation of the Human p21 Gene by Retinoic Acid Receptor

1996 • 314 citations

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.

1993 • 307 citations

PML, a growth suppressor disrupted in acute promyelocytic leukemia.

1994 • 296 citations

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

1992 • 277 citations

Activation of Retinoid X Receptors Induces Apoptosis in HL-60 Cell Lines

1995 • 247 citations

The PML growth-suppressor has an altered expression in human oncogenesis.

1995 • 241 citations

PML protein expression in hematopoietic and acute promyelocytic leukemia cells

1993 • 237 citations

A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.

1993 • 233 citations

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.

1996 • 223 citations

The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

1996 • 206 citations

p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.

1995 • 197 citations

Retinoid differentiation therapy in promyelocytic leukemia

1996 • 130 citations

Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies

1997 • 123 citations

Stat1 Is Induced and Activated by All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells

1997 • 120 citations

Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.

1994 • 111 citations

PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu.

1995 • 97 citations

Retinoic acid enhances the expression of interferon-induced proteins: evidence for multiple mechanisms of action

1997 • 96 citations

9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia

1995 • 92 citations

A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.

1992 • 89 citations

Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways.

1995 • 89 citations

Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells

1994 • 70 citations

Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6-[3-(1-adamantyl)hydroxyphenyl]-2-naphtalene carboxylic acid (CD437)

1997 • 67 citations

Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells

1994 • 62 citations

Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid induces apoptosis independent of maturation and Bcl-2 expression.

1995 • 43 citations

Differential changes of retinoid-X-receptor (RXR alpha) and its RAR alpha and PML-RAR alpha partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells.

1996 • 36 citations

The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells.

1995 • 33 citations

Altered Sensitivity to Retinoid-Induced Apoptosis Associated with Changes in the Subcellular Distribution of Bcl-2

1997 • 27 citations

Interferons induce normal and aberrant retinoic-acid receptors type α in acute promyelocytic leukemia cells: Potentiation of the induction of retinoid-dependent differentiation markers

1996 • 25 citations

Simple and efficient recovery of rare living lymphoid cells from a vast majority of dead cells

1994 • 7 citations