Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

1997 • 808 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia.

1997 • 546 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

1999 • 539 citations

Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

1999 • 538 citations

Vascular Endothelial Growth Factor, a Possible Paracrine Growth Factor in Human Acute Myeloid Leukemia

1997 • 465 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells

1998 • 355 citations

Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors

1995 • 285 citations

Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations

1999 • 281 citations

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients.

1999 • 228 citations

Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

1998 • 228 citations

Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells.

1999 • 208 citations

Arsenic Trioxide and Interferon- Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I–Transformed Cells

1999 • 181 citations

Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells

1998 • 160 citations

The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms

1998 • 159 citations

Arsenic induces apoptosis in B‐cell leukaemic cell lines in vitro: activation of caspases and down‐regulation of Bcl‐2 protein

1998 • 129 citations

Comparative Activity of Melarsoprol and Arsenic Trioxide in Chronic B-Cell Leukemia Lines

1997 • 112 citations

Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases

1999 • 81 citations

Activation-dependent alpha5beta1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells

1996 • 81 citations

Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression

1999 • 75 citations

Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines

1999 • 70 citations

Arsenic trioxide induces apoptosis of oesophageal carcinoma in vitro.

1999 • 60 citations

Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia

1999 • 28 citations

Arsenic and all-trans retinoic acid as induction therapy before autograft in a case of relapsed resistant secondary acute promyelocytic leukemia

1999 • 18 citations

Deleted Work

1955 • 0 citations