Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

1997 • 808 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Acute Promyelocytic Leukemia

2015 • 764 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1993 • 602 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 474 citations

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

1992 • 441 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 412 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 384 citations

All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia [see comments]

1995 • 379 citations

Biochemistry of the Essential Ultratrace Elements

1984 • 334 citations

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.

1993 • 307 citations

PML, a growth suppressor disrupted in acute promyelocytic leukemia.

1994 • 296 citations

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

1991 • 291 citations

Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells.

1993 • 282 citations

The PML growth-suppressor has an altered expression in human oncogenesis.

1995 • 241 citations

PML protein expression in hematopoietic and acute promyelocytic leukemia cells

1993 • 237 citations

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.

1996 • 223 citations

The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

1996 • 206 citations

Suppression of Retinoic Acid Receptor in Non-Small-Cell Lung Cancer In Vivo: Implications for Lung Cancer Development

1997 • 204 citations

Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture

1985 • 188 citations

A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα Mutation

1997 • 159 citations

Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alpha.

1994 • 129 citations

Phosphorylation of the retinoic acid receptor-alpha by protein kinase A.

1995 • 122 citations

Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein

1993 • 111 citations

Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia

1995 • 106 citations

Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.

1989 • 100 citations

9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia

1995 • 92 citations

A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.

1992 • 89 citations

Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase

1996 • 88 citations

Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines

1996 • 82 citations

Characterization of transglutaminase activity in rabbit tracheal epithelial cells. Regulation by retinoids.

1986 • 81 citations

Novel Retinoic Acid Receptor- Transcripts in Acute Promyelocytic Leukemia Responsive to All-trans-Retinoic Acid

1990 • 80 citations

Rapid Induction of CD38 Antigen on Myeloid Leukemia Cells by All trans-Retinoic Acid

1993 • 72 citations

Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase

1996 • 70 citations

Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation.

1992 • 65 citations

A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias.

1996 • 55 citations

Retinoic acid nuclear receptor β inhibits breast carcinoma anchorage independent growth

1995 • 54 citations

RARβ2-Mediated Growth Inhibition in HeLa Cells

1996 • 48 citations

Effects of arsenic on DNA damage and repair in human fetal lung fibroblasts

1994 • 47 citations

Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells.

1995 • 44 citations

Phosphorylation of the retinoic acid receptor-alpha by protein kinase A

1995 • 34 citations

The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells.

1995 • 33 citations

PML/RARalpha, a fusion protein in acute promyelocytic leukemia, prevents growth factor withdrawal-induced apoptosis in TF-1 cells.

1995 • 17 citations