Genetic polymorphism in the biotransformation of inorganic arsenic and its role in toxicity

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1980 • 3,166 citations

Arsenic: exposure and health effects

1998 • 797 citations

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

1997 • 765 citations

Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic

1977 • 723 citations

Biological Monitoring of Toxic Metals

1988 • 548 citations

Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man

1981 • 536 citations

Exposure to Inorganic Arsenic Metabolites during Early Human Development

1998 • 381 citations

Methylation of Inorganic Arsenic in Different Mammalian Species and Population Groups

1999 • 362 citations

Exposure to Inorganic Arsenic Metabolites during Early Human Development

1998 • 347 citations

Comparative Inhibition of Yeast Glutathione Reductase by Arsenicals and Arsenothiols

1997 • 302 citations

Methylation study of a population environmentally exposed to arsenic in drinking water.

1996 • 281 citations

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

1996 • 246 citations

Species differences in the metabolism of arsenic compounds

1994 • 230 citations

Metabolism of inorganic arsenic (74As) in humans following oral ingestion

1979 • 223 citations

A chemical hypothesis for arsenic methylation in mammals

1993 • 220 citations

Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and T1 among current arsenic-exposed residents in Taiwan

1997 • 217 citations

Multiple risk factors associated with arsenic-induced skin cancer: effects of chronic liver disease and malnutritional status

1995 • 216 citations

Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man.

1996 • 213 citations

Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina.

1998 • 207 citations

Intracellular interaction and metabolic fate of arsenite and arsenate in mice and rabbits

1983 • 205 citations

Study of inorganic arsenic methylation by rat liver in vitro: relevance for the interpretation of observations in man

1985 • 205 citations

Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit

1987 • 202 citations

Altered profile of urinary arsenic metabolites in adults with chronic arsenicism

1997 • 194 citations

Enzymic Methylation of Arsenic Compounds: Assay, Partial Purification, and Properties of Arsenite Methyltransferase and Monomethylarsonic Acid Methyltransferase of Rabbit Liver

1995 • 164 citations

Human Studies Do Not Support the Methylation Threshold Hypothesis for the Toxicity of Inorganic Arsenic

1993 • 163 citations

Biotransformation of dimethylarsinic acid in mouse, hamster and man

1987 • 160 citations

Relative genotoxic potency of arsenic and its methylated metabolites

1997 • 160 citations

In vivo reduction of arsenate in mice and rabbits

1983 • 154 citations

Urinary Excretion of Arsenic Species After Exposure to Arsenic Present in Drinking Water

1998 • 153 citations

The role of the methylation in the detoxication of arsenate in the rabbit

1985 • 152 citations

Role of thiols in the in-vitro methylation of inorganic arsenic by rat liver cytosol

1988 • 151 citations

Tissue distribution and retention of74As-dimethylarsinic acid in mice and rats

1984 • 146 citations

Metabolism of Arsenic in Primary Cultures of Human and Rat Hepatocytes

1999 • 143 citations

The effect of methyltransferase inhibition on the metabolism of [74As]arsenite in mice and rabbits

1984 • 141 citations

Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction

1996 • 139 citations

Low-level arsenic excretion in breast milk of native Andean women exposed to high levels of arsenic in the drinking water

1998 • 136 citations

Reduction and binding of arsenate in marmoset monkeys

1985 • 124 citations

Separation of arsenic metabolites in dog plasma and urine following intravenous injection of 74As

1978 • 119 citations

Enzymatic Methylation of Arsenic Compounds

1998 • 114 citations

Guanidinoacetate methyltransferase deficiency: New clinical features

1997 • 110 citations

Lack of Methylation of Inorganic Arsenic in the Chimpanzee

1995 • 106 citations

Inorganic and Methylated Arsenic Compounds Induce Cell Death in Murine Macrophages via Different Mechanisms

1998 • 101 citations

The biological alkylation of heavy elements

1989 • 89 citations

Arsenic uptake and metabolism by liver cells is dependent on arsenic oxidation state

1983 • 85 citations

Induction of Metallothionein by Arsenicals in Mice

1993 • 83 citations

The Metabolism of Arsenic in Humans Acutely Intoxicated by AS2O3. Its Significance for the Duration of BAL Therapy

1981 • 71 citations

Increased neurotoxicity of arsenic in methylenetetrahydrofolate reductase deficiency

1992 • 69 citations

DOSE-DEPENDENT EFFECTS ON THE DISPOSITION OF MONOMETHYLARSONIC ACID AND DIMETHYLARSINIC ACID IN THE MOUSE AFTER INTRAVENOUS ADMINISTRATION

1998 • 68 citations

Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines

1997 • 66 citations

The Biological alkylation of heavy elements

1988 • 57 citations

Studies of arsenic ingestion from drinking-water in Northeastern Taiwan: chemical speciation and urinary metabolites

1997 • 54 citations

Variation in Human Metabolism of Arsenic

1999 • 53 citations

Pharmacogenetics of N-methylation: Heritability of human erythrocyte histamine N-methyltransferase activity

1988 • 43 citations

Human HistamineN-Methyltransferase Gene: Structural Characterization and Chromosomal Localization

1996 • 36 citations

Mouse Liver Nicotinamide N-Methyltransferase:

1997 • 34 citations

Intercomparison of analytical methods for arsenic speciation in human urine.

1997 • 33 citations

Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains

1996 • 20 citations

Enzymatic methylation of arsenic compounds: II — an overview

1997 • 17 citations