Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoic acid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

1997 • 1,090 citations

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)

1991 • 884 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

1997 • 808 citations

Acute Promyelocytic Leukemia

2015 • 764 citations

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1993 • 602 citations

Molecular Remission in PML/RARα-Positive Acute Promyelocytic Leukemia by Combined All-trans Retinoic Acid and Idarubicin (AIDA) Therapy

1997 • 492 citations

APMLRARα transgene initiates murine acute promyelocytic leukemia

1997 • 455 citations

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

1997 • 373 citations

Acute leukemia with promyelocytic features in PML/RARα transgenic mice

1997 • 366 citations

UKCCCR guidelines for the welfare of animals in experimental neoplasia

1988 • 313 citations

Retinoic Acid and Arsenic Synergize to Eradicate Leukemic Cells in a Mouse Model of Acute Promyelocytic Leukemia

1999 • 308 citations

All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Japan Adult Leukemia Study Group [see comments]

1995 • 258 citations

Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells

1998 • 160 citations

Acute promyelocytic leukemia: biology and treatment.

1997 • 138 citations

Commentary on and reprint of Huang M-E, Ye Y-C, Chen S-R, Chai J-R, Lu J-X, Zhoa L, Gu L-J, Wang Z-Y, Use of all-trans-retinoic acid in the treatment of acute promyelocytic leukemia, in Blood (1988) 72:567–572

2000 • 128 citations

Acute promyelocytic leukemia: a curable disease

1998 • 121 citations

Transgenic expression of PML/RARalpha impairs myelopoiesis.

1996 • 107 citations

Propagation of human blastic myeloid leukemias in the SCID mouse

1992 • 99 citations

Growth of human myeloid leukemias in the human marrow environment of SCID-hu mice

1993 • 89 citations

Establishment and characterization of a novel acute promyelocytic leukemia cell line (UF-1) with retinoic acid-resistant features

1996 • 65 citations

UKCCCR guidelines for the welfare of animals in experimental neoplasia

1988 • 63 citations

A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias.

1996 • 55 citations

Retinoid Resistance in Leukemic Cells

1997 • 24 citations

Establishment of human granulocyte‐macrophage colony stimulating factor producing transgenic SCID mice

1996 • 13 citations

Cytokine dependent growth of human TF-1 leukemic cell line in human GM-CSF and IL-3 producing transgenic SCID mice

1998 • 12 citations

Establishment of a retinoic acid-resistant human acute promyelocytic leukaemia (APL) model in human granulocyte-macrophage colony-stimulating factor (hGM-CSF) transgenic severe combined immunodeficiency (SCID) mice

1998 • 10 citations