Use of arsenic trioxide (As2O3) in the treatment of patients with acute promyelocytic leukemia

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

United States Multicenter Study of Arsenic Trioxide in Relapsed Acute Promyelocytic Leukemia

2001 • 825 citations

Acute Promyelocytic Leukemia

2015 • 764 citations

Molecular Remission in PML/RARα-Positive Acute Promyelocytic Leukemia by Combined All-trans Retinoic Acid and Idarubicin (AIDA) Therapy

1997 • 492 citations

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 412 citations

Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

2000 • 258 citations

Therapy of Molecular Relapse in Acute Promyelocytic Leukemia

1999 • 242 citations

Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide

2001 • 242 citations

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients.

1999 • 228 citations

Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner

1998 • 228 citations

Genetic Diagnosis and Molecular Monitoring in the Management of Acute Promyelocytic Leukemia

1999 • 219 citations

Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo

2001 • 205 citations

Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines.

2000 • 191 citations

Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro

1999 • 188 citations

The unique aspects of acute promyelocytic leukemia.

1990 • 183 citations

Experience with gemtuzumab ozogamycin (“mylotarg”) and all-trans retinoic acid in untreated acute promyelocytic leukemia

2002 • 176 citations

Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide

2001 • 170 citations

The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms

1998 • 159 citations

Molecular Remissions Induced by Liposomal-Encapsulated All-Trans Retinoic Acid in Newly Diagnosed Acute Promyelocytic Leukemia

1999 • 106 citations

All- trans retinoic acid significantly increases 5-year survival in patients with acute promyelocytic leukemia: long-term follow-up of the New York study

1997 • 74 citations

Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines

1999 • 70 citations

Alterations in tretinoin pharmacokinetics following administration of liposomal all-trans retinoic acid

1996 • 68 citations

Arsenicals in hematologic cancers.

2000 • 57 citations

Therapy of acute promyelocytic leukemia: all-trans retinoic acid and beyond.

1998 • 50 citations

All-trans retinoic acid followed by chemotherapy for salvage of refractory or relapsed acute promyelocytic leukemia

1994 • 44 citations

Novel therapeutic agents for the treatment of myelodysplastic syndromes.

2000 • 44 citations

Retinoic Acid Syndrome Induced by Arsenic Trioxide in Treating Recurrent All-Trans Retinoic Acid Resistant Acute Promyelocytic Leukemia

2000 • 34 citations

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