Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis, and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment, and cell cycle phase.

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide

1998 • 1,220 citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1996 • 843 citations

Studies on Treatment of Acute Promyelocytic Leukemia With Arsenic Trioxide: Remission Induction, Follow-Up, and Molecular Monitoring in 11 Newly Diagnosed and 47 Relapsed Acute Promyelocytic Leukemia Patients

1999 • 630 citations

Arsenic: health effects, mechanisms of actions, and research issues.

1999 • 604 citations

Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

1999 • 539 citations

Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

1999 • 538 citations

Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis.

2000 • 326 citations

Arsenite Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

1999 • 307 citations

Apoptosis and Growth Inhibition in Malignant Lymphocytes After Treatment With Arsenic Trioxide at Clinically Achievable Concentrations

1999 • 281 citations

Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

2000 • 258 citations

Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-xL

2000 • 242 citations

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients.

1999 • 228 citations

Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells.

1999 • 208 citations

Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro

1999 • 188 citations

Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.

1999 • 183 citations

Arsenic Trioxide and Interferon- Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I–Transformed Cells

1999 • 181 citations

Caspases Mediate Retinoic Acid–Induced Degradation of the Acute Promyelocytic Leukemia PML/RARα Fusion Protein

1998 • 172 citations

Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide

1999 • 147 citations

Induced Differentiation of U937 Cells by 1,25-dihydroxyvitamin D3 Involves Cell Cycle Arrest in G1 That Is Preceded by a Transient Proliferative Burst and an Increase in Cyclin Expression

1999 • 105 citations

Leukemia Cell Differentiation

1999 • 92 citations

Sodium arsenite disturbs mitosis and induces chromosome loss in human fibroblasts.

1997 • 88 citations

Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases

1999 • 81 citations

Arsenite inhibits mitotic division and perturbs spindle dynamics in HeLa S3 cells

1998 • 81 citations

Effect of Arsenic Trioxide on Cell Cycle Arrest in Head and Neck Cancer Cell Line PCI-1

1999 • 78 citations

Mechanisms involved in sodium arsenite-induced apoptosis of human neutrophils

1996 • 72 citations

Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines

1999 • 70 citations

Arsenic: opportunity for risk assessment

1991 • 70 citations

Selective induction of apoptosis of NB4 cells from G2+M phase by sodium arsenite at lower doses

1998 • 42 citations