Arsenic induces overexpression of growth factors in human keratinocytes

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Cancer risks from arsenic in drinking water.

1992 • 1,069 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Arsenic: exposure and health effects

1998 • 797 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers.

1985 • 618 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Arsenic in the Environment

1975 • 508 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan.

1995 • 438 citations

Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.

1991 • 437 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

1990 • 397 citations

Arsenic in the environment part II: Human health and ecosystem effects

1995 • 392 citations

Cytokine Modulation of Keratinocyte Cytokines

1990 • 345 citations

Ingested Arsenic and Internal Cancer: A Historical Cohort Study Followed for 33 Years

1995 • 313 citations

Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.

1995 • 253 citations

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

1988 • 227 citations

Induction of Gene Amplification by Arsenic

1988 • 215 citations

Cytokine Induction in Human Epidermal Kerationocytes Exposed to Contact Irritants and Its Relation to Chemical-Induced Inflammation in Mouse Skin

1994 • 213 citations

Multiple arsenical cancers of skin and internal organs

1953 • 186 citations

Keratinocyte growth regulation by the products of immune cells.

1988 • 172 citations

Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines.

1988 • 164 citations

Role of Tumor Necrosis Factor-α in Cadmium-Induced Hepatotoxicity

1995 • 161 citations

Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas.

1993 • 153 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

1992 • 137 citations

Induction of Transforming Growth Factor-α Expression in Human Keratinocytes by Phorbol Esters

1989 • 131 citations

Dioxin induces transforming growth factor-alpha in human keratinocytes

1991 • 114 citations

Skin Immune System

2009 • 111 citations

GM-CSF Activates Regenerative Epidermal Growth and Stimulates Keratinocyte Proliferation in Human Skin In Vivo

1994 • 109 citations

Altered Regulation of TGF‐β1 and TGF‐α in Primary Keratinocytes and Papillomas Expressing v‐Ha‐ras

1991 • 94 citations

[22] Isolation and analysis of nuclear RNA

1987 • 91 citations

Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor‐inducing effect of wounding in initiated nmri mouse skin

1989 • 83 citations

Production of Interleukin-1 and Interleukin-6 by Human Keratinocytes and Squamous Cell Carcinoma Cell Lines

1991 • 83 citations

Autocrine Stimulation of Interleukin-1α and Transforming Growth Factorα Production in Human Keratinocytes and Its Antagonism by Glucocorticoids

1991 • 76 citations

Evidence for autocrine/paracrine growth stimulation by transforming growth factor‐α during the process of skin tumor promotion

1991 • 72 citations

TGFα stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression

1988 • 70 citations

Heat Shock Proteins in Cultured Human Keratinocytes and Fibroblasts

1991 • 70 citations

Arsenic: opportunity for risk assessment

1991 • 70 citations

Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.

1995 • 67 citations

Autocrine growth limitation of human papillomavirus type 16-harboring keratinocytes by constitutively released tumor necrosis factor-alpha.

1992 • 63 citations

Collaboration between growth factors and diverse chemical carcinogens in hepatocarcinogenesis of transforming growth factor alpha transgenic mice.

1993 • 47 citations

Reciprocal Cytokine-Mediated Cellular Interactions in Mouse Epidermis: Promotion of γ δ T-Cell Growth by IL-7 and TNFα and Inhibition of Keratinocyte Growth by γIFN

1993 • 46 citations

The Hormonal Control of Gene Transcription

1991 • 42 citations

Arsenate perturbation of human keratinocyte differentiation.

1994 • 41 citations

Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor ? inhibitors

1996 • 38 citations

Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor alpha mediates the induction of keratin 8 by the v-rasHa oncogene.

1993 • 36 citations

The Estimated Daily Loss of Trace Elements from Normal Skin by Desquamation

1976 • 32 citations

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in mouse skin in response to tumor-promoting agents and modulates dermal inflammation and epidermal dark cell numbers

1994 • 26 citations

A comparison of the stimulatory effects of cytokines on normal and psoriatic keratinocytes in vitro

1995 • 26 citations

Sodium arsenite and heat shock induce stress proteins in precision-cut rat liver slices

1995 • 24 citations

Granulocyte-macrophage colony stimulating factor gene expression and function during tumor promotion

1994 • 23 citations

Serum‐stimulated cell cycle progression and stress protein synthesis in C3H10T1/2 fibroblasts treated with sodium arsenite

1993 • 23 citations

The Estimated Daily Loss of Trace Elements from Normal Skin by Desquamation

1976 • 16 citations

Long-Term Cultured Adult Human Keratinocytes Secrete Granulocyte-Macrophage Colony-Stimulating Factor but Not Interleukin-3 after Cytokine Exposure in vitro

1991 • 14 citations

In vitro DNA synthesis of mouse hepatocytes stimulated by tumor necrosis factor is inhibited by glucocorticoids and prostaglandin D₂ but enhanced by retinoic acid

1993 • 13 citations

Regulation of transcription by transforming growth factor-β

1991 • 11 citations

Alterations of methylation of the tumor suppressor gene p53: insights into potential mechanisms of arsenic carcinogenesis

1997 • 3 citations