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Immune surveillance in the skin: mechanisms and clinical consequences

Data up to Jan 2025

Published2004
Citations736
References168

Total Citations Per Year

Abstract

References (168)

Dendritic cells and the control of immunity

1998 • 14,345 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-Like Receptors

2003 • 6,127 citations

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Atopic Dermatitis: Global Epidemiology and Risk Factors

2015 • 2,759 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

The histogenesis and biologic behavior of primary human malignant melanomas of the skin.

1969 • 2,098 citations

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 • 1,989 citations

Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis

2002 • 1,898 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Nuclear factor-κB

2004 • 1,545 citations

Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response

1997 • 1,536 citations

Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2

1999 • 1,500 citations

T-Cell Function and Migration — Two Sides of the Same Coin

2000 • 1,437 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Model Predicting Survival in Stage I Melanoma Based on Tumor Progression

1989 • 1,235 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma

1996 • 1,110 citations

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

2003 • 1,058 citations

A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma

1984 • 963 citations

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

2001 • 798 citations

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

2001 • 792 citations

CCL27–CCR10 interactions regulate T cell–mediated skin inflammation

2002 • 773 citations

Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

1998 • 761 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Cytokine Milieu of Atopic Dermatitis, as Compared to Psoriasis, Skin Prevents Induction of Innate Immune Response Genes

2003 • 727 citations

A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

1998 • 721 citations

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

1995 • 622 citations

Complete molecular remissions induced by patient-specific vaccination plus granulocyte–monocyte colony-stimulating factor against lymphoma

1999 • 604 citations

Expression of Mouse Interleukin-4 by a Recombinant Ectromelia Virus Suppresses Cytolytic Lymphocyte Responses and Overcomes Genetic Resistance to Mousepox

2001 • 550 citations

A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites.

1990 • 512 citations

CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin

2001 • 502 citations

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

1999 • 502 citations

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

2002 • 496 citations

Inflammatory Skin Diseases, T Cells, and Immune Surveillance

1999 • 474 citations

High Frequency of Skin-homing Melanocyte-specific Cytotoxic T Lymphocytes in Autoimmune Vitiligo

1998 • 446 citations

Dermal injection of immunocytes induces psoriasis.

1996 • 441 citations

Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

2002 • 440 citations

IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach.

1998 • 414 citations

Immunomorphological and Ultrastructural Characterization of Langerhans Cells and a Novel, Inflammatory Dendritic Epidermal Cell (IDEC) Population in Lesional Skin of Atopic Eczema

1996 • 404 citations

Nuclear factor-κB

1997 • 393 citations

Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

2003 • 392 citations

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

2002 • 384 citations

Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans

2002 • 368 citations

Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family

2000 • 357 citations

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

2000 • 355 citations

Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation.

1987 • 352 citations

Cutting Edge: Distinct Toll-Like Receptor 2 Activators Selectively Induce Different Classes of Mediator Production from Human Mast Cells

2003 • 351 citations

CCR7 Expression and Memory T Cell Diversity in Humans

2001 • 342 citations

Control of adaptive immune responses by Toll-like receptors

2002 • 335 citations

Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell–derived cytokines

2001 • 300 citations

Biology and clinical relevance of naturally occurring antimicrobial peptides

2002 • 292 citations

Saccharomyces cerevisiae‐ and Candida albicans‐Derived Mannan Induced Production of Tumor Necrosis Factor Alpha by Human Monocytes in a CD14‐ and Toll‐Like Receptor 4‐Dependent Manner

2002 • 291 citations

Dendritic cells: On the move from bench to bedside

2001 • 291 citations

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen.

1995 • 291 citations

Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization.

1993 • 279 citations

Barrier Disruption Stimulates Interleukin-1α Expression and Release from a Pre-Formed Pool in Murine Epidermis

1996 • 275 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

Specialized Contributions by α(1,3)-Fucosyltransferase-IV and FucT-VII during Leukocyte Rolling in Dermal Microvessels

2000 • 261 citations

Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells.

1995 • 248 citations

Increased CCR4 Expression in Cutaneous T Cell Lymphoma

2002 • 248 citations

Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes

2002 • 244 citations

Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses

2000 • 241 citations

The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity

2001 • 240 citations

Tumor immunity and autoimmunity induced by immunization with homologous DNA.

1998 • 233 citations

Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions

1999 • 224 citations

Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen.

1995 • 224 citations

Cellular and immunologic mechanisms in atopic dermatitis

2001 • 221 citations

Epidemiology of atopic dermatitis

2000 • 217 citations

Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity

2002 • 208 citations

Cutaneous Graft-versus-Host Disease

1998 • 206 citations

Interleukin-1 and Cutaneous Inflammation: A Crucial Link Between Innate and Acquired Immunity

2000 • 204 citations

Human CD25+ Regulatory T Cells Maintain Immune Tolerance to Nickel in Healthy, Nonallergic Individuals

2003 • 204 citations

Interleukin 7 is produced by murine and human keratinocytes.

1993 • 198 citations

Major histocompatibility antigens and mononuclear inflammatory infiltrate in benign nevomelanocytic proliferations and malignant melanoma.

1982 • 193 citations

Dendritic Cell Immunization Route Determines CD8+ T Cell Trafficking to Inflamed Skin: Role for Tissue Microenvironment and Dendritic Cells in Establishment of T Cell-Homing Subsets

2004 • 191 citations

Cutaneous T Cell Lymphoma

2001 • 184 citations

Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance

1999 • 178 citations

Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma

2003 • 176 citations

Direct evidence to support the immunosurveillance concept in a human regressive melanoma.

1994 • 171 citations

GM-CSF-secreting melanoma vaccines

2003 • 171 citations

An overview of poxviruses

2001 • 170 citations

The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS.

2003 • 166 citations

Allergic contact dermatitis: the cellular effectors

2002 • 164 citations

The Interleukin-1 Axis and Cutaneous Inflammation

1995 • 163 citations

P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is a Physiological Ligand for E-Selectin in Mediating T Helper 1 Lymphocyte Migration

2000 • 162 citations

Expression of mucosal homing receptor alpha4beta7 by circulating CD4+ cells with memory for intestinal rotavirus.

1997 • 149 citations

Immunologic aspects of dermal and oral lichen planus

1997 • 149 citations

Smallpox vaccination: Risk considerations for patients with atopic dermatitis

2002 • 138 citations

Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. Evidence for in situ T cell clonal expansion.

1993 • 135 citations

Clinical cancer vaccine trials

2002 • 134 citations

Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial

2002 • 133 citations

Smallpox Vaccination Reactions, Prophylaxis, and Therapy of Complications

1975 • 132 citations

Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation

2002 • 131 citations

The Role of α-Melanocyte-Stimulating Hormone in Cutaneous Biology

1997 • 131 citations

The prevalence of skin disease in HIV infection and its relationship to the degree of immunosuppression

1997 • 130 citations

Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus

2002 • 124 citations

Cutaneous lymphocyte antigen‐positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis

1996 • 122 citations

Evidence for in situ amplification of cytotoxic T-lymphocytes with antitumor activity in a human regressive melanoma.

1993 • 121 citations

Immune Surveillance and Effector Functions of CCR10+ Skin Homing T Cells

2002 • 121 citations

Atopic dermatitis: immunobiology and treatment with immune modulators.

1997 • 112 citations

A Second Step of Chemotaxis After Transendothelial Migration: Keratinocytes Undergoing Apoptosis Release IFN-γ-Inducible Protein 10, Monokine Induced by IFN-γ, and IFN-γ-Inducible α-Chemoattractant for T Cell Chemotaxis Toward Epidermis in Atopic Dermatitis

2003 • 112 citations

Cutting Edge: C-C Chemokine Receptor 6 Is Essential for Arrest of a Subset of Memory T Cells on Activated Dermal Microvascular Endothelial Cells Under Physiologic Flow Conditions In Vitro

2000 • 111 citations

The Immunopemthogenesis of Cutaneous T-cell Lymphoma

1995 • 108 citations

Dendritic cell-based cancer immunotherapy

2003 • 106 citations

Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo

2002 • 106 citations

E-Selectin, Thymus- and Activation-Regulated Chemokine/CCL17, and Intercellular Adhesion Molecule-1 Are Constitutively Coexpressed in Dermal Microvessels: A Foundation for a Cutaneous Immunosurveillance System

2004 • 104 citations

Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus

2002 • 104 citations

Effect of In Vivo Interleukin-1 on Adhesion Molecule Expression in Normal Human Skin

1992 • 103 citations

Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions

2000 • 97 citations

THE PATHOGENESIS OF ALOPECIA AREATA

1996 • 96 citations

Homing of intravenously and intralymphatically injected human dendritic cells generated in vitro from CD34 + hematopoietic progenitor cells

1999 • 93 citations

The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease

2001 • 92 citations

T-cell subpopulations in the development of atopic and contact allergy

2001 • 92 citations

Toll-like receptors: mammalian 'taste receptors' for a smorgasbord of microbial invaders

2002 • 89 citations

Molecular Basis of Allergic Diseases

1998 • 89 citations

Interleukin-18 Is Elevated in the Sera from Patients with Atopic Dermatitis and from Atopic Dermatitis Model Mice, NC/Nga

2001 • 88 citations

Skin‐homing CLA+T cells and regulatory CD25+T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I‐309

2002 • 83 citations

Cyclosporine in the Treatment of Dermatologic Disease: An Update

1996 • 82 citations

Skin-homing CLA+ T cells and regulatory CD25+ T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309

2002 • 82 citations

Prevalence and clinical spectrum of skin diseases in kidney transplant recipients

1991 • 81 citations

Immunologic Responses to Vaccinia Vaccines Administered by Different Parenteral Routes

1997 • 76 citations

Pathogenesis of cutaneous T-cell lymphoma: implications for the use of recombinant cytokines and photopheresis.

1997 • 74 citations

Keratinocytes in epidermal immune responses

2001 • 72 citations

Toll-Like Receptor-Mediated Activation of Mast Cells: Implications for Allergic Disease?

2003 • 72 citations

Interferon-γ promotes exaggerated cytokine production in keratinocytes cultured from patients with atopic dermatitis

1998 • 70 citations

Pathogenesis of Psoriasis: Current Concepts

1995 • 69 citations

Immunological pathomechanisms in vitiligo

2001 • 68 citations

The Responses of Normal and Psoriatic Skin to Single and Multiple Topical Applications of Leukotriene B4

1985 • 66 citations

In situ expression of the costimulatory molecules CD80 and CD86 on Langerhans cells and inflammatory dendritic epidermal cells (IDEC) in atopic dermatitis

2001 • 66 citations

OLD, NEW, AND EMERGING THERAPIES FOR ATOPIC DERMATITIS

2000 • 66 citations

Developing recombinant and synthetic vaccines for the treatment of melanoma

1999 • 62 citations

Epidemiology of atopic dermatitis.

1987 • 62 citations

Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen

2003 • 60 citations

Distinct phenotype of leukemic T cells with various tissue tropisms.

1997 • 58 citations

Expression of cutaneous lymphocyte-associated antigen on human CD4+ and CD8+ Th2 cells

2000 • 57 citations

Current management and therapy of atopic dermatitis

2001 • 55 citations

Atopic Dermatitis: Molecular Mechanisms, Clinical Aspects and New Therapeutical Approaches

2003 • 53 citations

Novel Therapies for Psoriasis

2002 • 53 citations

Cytokine blocking agents in dermatology

2002 • 51 citations

Long-Lived Th2 Clones Specific for Seasonal and Perennial Allergens Can Be Detected in Blood and Skin by Their TCR-Hypervariable Regions

1998 • 51 citations

Spontaneous leukocyte rolling in venules in untraumatized skin of conscious and anesthetized animals

1994 • 48 citations

Skin-homing T cells in human cutaneous allergic inflammation

1995 • 46 citations

Overexpression of the T-cell receptor beta-chain variable region TCRBV14 in HLA-A2-matched primary human melanomas.

1995 • 43 citations

The British Association of Dermatologists audit of atopic eczema management in secondary care. Phase 3: audit of service outcome

2000 • 42 citations

Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells

1996 • 40 citations

Differential expression of the HECA‐452 antigen (cutaneous lymphocyte associated antigen, CLA) in cutaneous and non‐cutaneous T‐cell lymphomas

1992 • 40 citations

Dendritic cell gene therapy

2002 • 32 citations

Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma

1995 • 31 citations

The role of keratinocytes in the pathogenesis of atopic dermatitis

2001 • 28 citations

Functional Cutaneous Lymphocyte Antigen Can Be Induced in Essentially All Peripheral Blood T Lymphocytes

1999 • 27 citations

Gene therapy to target dendritic cells from blood to lymph nodes

2003 • 27 citations

Smallpox: clinical and epidemiologic features.

2002 • 27 citations

Perforin hyperreleasability and depletion in cytotoxic T cells from patients with exacerbated atopic dermatitis and asymptomatic rhinoconjunctivitis allergica

2001 • 26 citations

T lymphocytes expressing HECA-452 epitope are present in cutaneous acute graft-versus-host disease and erythema multiforme, but not in acute graft-versus-host disease in gut organs.

1992 • 23 citations

Image analysis of Stage 1 melanoma (1.00–2.50 mm): lymphocytic infiltrates related to metastasis and survival

1992 • 23 citations

Participation of T lymphocytes in cutaneous allergic reactions to drugs.

1998 • 23 citations

Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity

1996 • 21 citations

Vaccines and melanoma

2002 • 19 citations

Investigational therapies for psoriasis

2003 • 17 citations

ALLERGIC SKIN DISEASE

1998 • 15 citations

Vesiculobullous Diseases With Prominent Immunologic Features

1992 • 11 citations

The British Association of Dermatologists audit of atopic eczema management in secondary care. Phase 2: audit of service process

2000 • 6 citations

A survey of treatments used in patients with metastatic melanoma: analysis of 189 patients referred to the National Cancer Institute.

1999 • 6 citations

Clinical Immuno-Dermatology

1982 • 2 citations

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Immune surveillance in the skin: mechanisms and clinical consequences (2004) – Nature reviews. Immunology | Metascience Observatory Explorer