Nuclear factor-κB

Inflammation and cancer

2002 • 14,174 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

Inflammation and necrosis promote tumour growth

2004 • 646 citations

NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4

2003 • 624 citations

Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

2004 • 598 citations

NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia

2003 • 541 citations

Nuclear factor-kappa B and cancer: its role in prevention and therapy

2002 • 502 citations

Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κB

1998 • 500 citations

Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB

1998 • 435 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.

2002 • 428 citations

Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.

2003 • 422 citations

Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

2000 • 355 citations

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

2003 • 324 citations

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

2001 • 316 citations

Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen

1999 • 315 citations

TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways

2003 • 292 citations

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling.

1999 • 279 citations

Role of nitric oxide in tumour progression: lessons from human tumours.

1998 • 275 citations

Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaBalpha: correlation with induction of cyclooxygenase-2

2002 • 273 citations

12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter.

1994 • 266 citations

Transcription factor NF-κB is constitutively activated in acute lymphoblastic leukemia cells

2000 • 266 citations

The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells

2000 • 264 citations

Lipopolysaccharide‐induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion

2002 • 249 citations

Function of nuclear factor kappaB in pancreatic cancer metastasis.

2003 • 209 citations

Genomic Organization of Human and Mouse Genes for Vascular Endothelial Growth Factor C

1997 • 205 citations

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

1999 • 204 citations

Role of NF-κB in the Rescue of Multiple Myeloma Cells From Glucocorticoid-Induced Apoptosis by Bcl-2

1999 • 202 citations

Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines.

1994 • 178 citations

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

1999 • 160 citations

The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease

1999 • 145 citations

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

2004 • 142 citations

Transcriptional up-regulation of matrix metalloproteinase-9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK-N-SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT-box and nuclear factor kappaB elements.

1999 • 130 citations

Defective IκBα in Hodgkin cell lines with constitutively active NF-κB

1998 • 129 citations

Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells.

2003 • 119 citations

Identification of signal transduction pathways involved in constitutive NF-κB activation in breast cancer cells

2002 • 114 citations

Increased Expression of RelA/Nuclear Factor-κB Protein Correlates with Colorectal Tumorigenesis

2003 • 110 citations

Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes.

2002 • 102 citations

A labile repressor acts through the NFkB-like binding sites of the human urokinase gene

1991 • 97 citations

Ras regulation of NF-KB and apoptosis

2001 • 74 citations

Cellular Proliferation and Activation of NFκB Are Induced by Autocrine Production of Tumor Necrosis Factor α in the Human T Lymphoma Line HuT 78

1995 • 60 citations

Leukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression

2002 • 54 citations

Leukemia stem cells and constitutive activation of NF-κB

2001 • 41 citations

Constitutive activation of NF-κB in Ki-ras-transformed prostate epithelial cells

2002 • 39 citations

Elevated serum levels of p105erbB-2 in patients with advanced-stage prostatic adenocarcinoma

1996 • 35 citations

Circulating intercellular adhesion molecule-1 in patients with hepatocellular carcinoma before and after hepatic resection.

1997 • 25 citations