Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

1999 • 1,532 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Dermatology in General Medicine.

1988 • 1,130 citations

The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey.

2001 • 979 citations

Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial

2001 • 913 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

1995 • 622 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Treatment of Chronic Plaque Psoriasis by Selective Targeting of Memory Effector T Lymphocytes

2001 • 593 citations

Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection

2000 • 587 citations

Interleukin 20

2001 • 542 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

The Majority of Epidermal T Cells in Psoriasis Vulgaris Lesions can Produce Type 1 Cytokines, Interferon-γ, Interleukin-2, and Tumor Necrosis Factor-α, Defining TC1 (Cytotoxic T Lymphocyte) and TH1 Effector Populations:1 a Type 1 Differentiation Bias is also Measured in Circulating Blood T Cells in Psoriatic Patients

1999 • 479 citations

Inflammatory Skin Diseases, T Cells, and Immune Surveillance

1999 • 474 citations

Tolerance and Autoimmunity

2001 • 453 citations

Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

2000 • 384 citations

The interleukin-10 family of cytokines

2002 • 323 citations

Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells

2000 • 322 citations

Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.

1994 • 299 citations

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.

1996 • 287 citations

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice

2001 • 284 citations

Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation.

1994 • 282 citations

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

1996 • 270 citations

Injection of Pre-Psoriatic Skin with CD4+ T Cells Induces Psoriasis

1999 • 260 citations

Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions

1999 • 224 citations

Cyclosporine consensus conference: With emphasis on the treatment of psoriasis

1998 • 184 citations

IL-4 Is a Mediator of IL-12p70 Induction by Human Th2 Cells: Reversal of Polarized Th2 Phenotype by Dendritic Cells

2000 • 180 citations

Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint

2001 • 146 citations

Response of Psoriasis to Interleukin-10 is Associated with Suppression of Cutaneous Type 1 Inflammation, Downregulation of the Epidermal Interleukin-8/CXCR2 Pathway and Normalization of Keratinocyte Maturation

2001 • 125 citations

Possibilities and Limitations

1970 • 120 citations

Triggering of T cell proliferation through CD28 induces GATA‐3 and promotes T helper type 2 differentiationin vitroandin vivo

1999 • 108 citations

Systemic Tacrolimus (FK 506) Is Effective for the Treatment of Psoriasis in a Double-blind, Placebo-Controlled Study

1996 • 101 citations

Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiationin vitro andin vivo

1999 • 95 citations

Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo.

1993 • 91 citations

Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cells

2001 • 90 citations

Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris

1999 • 84 citations

Psoralen Bath Plus UV-A Therapy

1997 • 83 citations

Effects of Systemic Interleukin-10 Therapy on Psoriatic Skin Lesions: Histologic, Immunohistologic, and Molecular Biology Findings

2001 • 78 citations

Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo.

1994 • 74 citations

Systemic tacrolimus (FK506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study

1995 • 62 citations

Phase II Trial of Recombinant Human Interleukin-4 in Patients with Disseminated Malignant Melanoma

1998 • 47 citations

Safety Evaluation of Recombinant Human Interleukin-4

1997 • 33 citations

A strict requirement of interleukin-4 for interleukin-4 induction in antigen-stimulated human memory T cells

1996 • 30 citations

A phase II study of recombinant human interleukin-4 for advanced or recurrent non-small cell lung cancer.

1998 • 23 citations

Safety Evaluation of Recombinant Human Interleukin-4

1997 • 19 citations

Deleted Work

1955 • 0 citations