Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

The Optics of Human Skin

1981 • 2,363 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris

1985 • 993 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.

1990 • 707 citations

Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1).

1988 • 680 citations

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

1995 • 622 citations

Changes in Keratinocyte Maturation During Wound Healing

1987 • 375 citations

Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis.

1992 • 253 citations

CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.

1994 • 233 citations

IL-8 Gene Expression and Production in Human Keratinocytes and Their Modulation by UVB

1993 • 221 citations

Predominance of ?memory? T cells (CD4+, CDw29+) over ?naive? T cells (CD4+, CD45R+) in both normal and diseased human skin

1989 • 218 citations

CD11b+ macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein.

1994 • 197 citations

Acute Effects of Ultraviolet Radiation on the Skin

2018 • 196 citations

Dissection of an inflammatory process induced by CD8+ T cells

1990 • 187 citations

Regulation of Epidermal Cell Interleukin-6 production by UV Light and Corticosteroids

1991 • 181 citations

PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy.

1994 • 177 citations

T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vitro via secreted products

1994 • 152 citations

Studies of the Effect of Cyclosporine in Psoriasis In Vivo: Combined Effects on Activated T Lymphocytes and Epidermal Regenerative Maturation

1992 • 105 citations

The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor-alpha and by ultraviolet B radiation.

1993 • 93 citations

Cell membrane is a major locus for ultraviolet B-induced alterations in accessory cells.

1990 • 86 citations

The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptor.

1992 • 83 citations

The immunology of allergic contact dermatitis: the DNCB story.

1990 • 76 citations

The effect of UV therapy on immune function in patients with psoriasis

1993 • 60 citations

Ultraviolet radiation rapidly induces tyrosine phosphorylation and calcium signaling in lymphocytes.

1993 • 55 citations

Elevated Plasma Interleukin-1 Levels in Humans Following Ultraviolet Light Therapy for Psoriasis

1989 • 55 citations

Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells

1993 • 49 citations

Ultraviolet B-induced DNA fragmentation (apoptosis) in activated T-lymphocytes and Jurkat cells is augmented by inhibition of RNA and protein synthesis.

1992 • 45 citations

Involvement of interleukin-1 (IL-1), IL-6, IL-2, and IL-4 in generation of cytolytic T cells from thymocytes stimulated by a Mycoplasma fermentans-derived product

1991 • 38 citations

T-Lymphocyte Subsets in the Lesional Skin of Allogeneic and Autologous Bone Marrow Transplant Patients

1988 • 38 citations

Effect of low-dose ultraviolet-B radiation on the function of human T lymphocytesin vitro

1993 • 29 citations

Transforming Growth Factor α: In vivo Release by Normal Human Skin following UV Irradiation and Abrasion

1991 • 27 citations

Ultrastructural studies bearing on the mechanism of UVB-impaired induction of contact hypersensitivity to DNCB in man

1993 • 27 citations

Evidence of cytotoxic T-cell destruction of epidermal cells in human graft-vs-host disease. Immunohistology with monoclonal antibody TIA-1.

1992 • 27 citations

Activation of Neutrophil Membrane-Associated Oxidative Metabolism by Ultraviolet Radiation

1993 • 22 citations

Long-term ultraviolet B-induced impairment of Langerhans cell function: an immunoelectron microscopic study

1994 • 20 citations

In-vivo studies of the action spectrum and time course for release of transforming growth factor-α by ultraviolet irradiation in man

1991 • 16 citations

Phototherapy of psoriasis - clinical aspects and risk evaluation.

1982 • 15 citations

The effect of Goeckerman therapy on interferon in serum and suction blister fluid from patients with psoriasis

1986 • 14 citations

IFN-gamma, IL-6 and IL-4 Modulate M. leprae- or PPD-Specific Cytotoxic T Cells in Leprosy Patients

1993 • 9 citations

Lytic susceptibility of target cells to cytotoxic T cells is determined by their constitutive major histocompatibility complex class I antigen expression and cytokine-induced activation status.

1994 • 9 citations

UVB Radiation and Human Monocyte Accessory Function: Differential Effects on Pre-Mitotic Events in T-Cell Activation

1990 • 8 citations